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Search Results for " cyp11b1 "

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抑制剂 & 化合物

1

天然产物

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Cat. No. Product Name Target Signaling Pathways
T64249 CYP11B1-IN-2

CYP11B1-IN-2 (compound 7aa) 是一种选择性的、口服具有活力的 CYP11B1 抑制剂,能够作用于 human CYP11B1 (IC50: 9 nM) 和 rat CYP11B1 (IC50: 25 nM)。CYP11B1-IN-2 能够用于研究皮质醇过量所致疾病。
T4277 Osilodrostat

LCI699

Glucocorticoid Receptor; Others; Hydroxylase Endocrinology/Hormones; Metabolism; Others
Osilodrostat (LCI699) 是一种有效的人11β-羟化酶和醛固酮合成酶抑制剂,IC50分别值为2.5 和0.7nM。
T10922 CYP11B2-IN-1

P450 Metabolism
CYP11B2-IN-1 是一种有效的选择性 CYP11B2 抑制剂,对 CYP11B2 和 CYP11B1 的 IC50 分别为 2.3 nM 和 142 nM。
T14664 BI 689648

Others Others
BI 689648 is a highly selective inhibitor of aldosterone synthase(CYP11B1 and CYP11B2 with IC50s of 310 and 2.1 nM, respectively).

化合物

CYP11B1-IN-2
Cat.No: T64249
Synonym:
Target:
Osilodrostat
Cat.No: T4277
Synonym: LCI699
Target: Glucocorticoid Receptor, Others, Hydroxylase
CYP11B2-IN-1
Cat.No: T10922
Synonym:
Target: P450
BI 689648
Cat.No: T14664
Synonym:
Target: Others
Cat. No. Product Name Target Signaling Pathways
T36472 Tetrahydro-11-deoxy Cortisol

Tetrahydro-11-deoxy cortisol (THS) is the primary urinary metabolite of 11-deoxycortisol. Urinary excretion of THS is elevated in patients with 11β-hydroxylase deficiency, a condition resulting from mutations in the cytochrome P450 (CYP) isoform CYP11B1. Urinary levels of THS are also elevated in patients with adrenocortical carcinoma (ACC) and adrenocortical adenoma (ACA) but are higher in patients with ACC compared to ACA.

天然产物

Tetrahydro-11-deoxy Cortisol
Cat.No: T36472
Synonym:
Target:
TargetMol Loading
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