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Search Results for " cxcl8 "

9

抑制剂 & 化合物

12

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T83712	Interleukin-8 (54-72) (human) TFA IL-8 (54-72),C-X-C Motif Chemokine Ligand (54-72),CXCL8 (54-72)
	Interleukin-8 (IL-8) (54-72) 对应于成熟人类IL-8序列的第54至72个氨基酸以及预处理序列的第81至99个氨基酸的肽。它抑制了初级人类中性粒细胞基于流动的黏附至人类脐静脉内皮细胞(HUVECs)。
T5193	Danirixin GSK1325756	CXCR	Autophagy; GPCR/G Protein; Immunology/Inflammation
	Danirixin (GSK1325756) 是一种选择性可逆的CXCR2拮抗剂，抑制 CXCL8 的IC50值为 12.5 nM。
T4163	Reparixin DF 1681Y,Repertaxin,瑞帕利辛	CXCR	Autophagy; GPCR/G Protein; Immunology/Inflammation
	Reparixin (Repertaxin) 是两种 CXCL8 受体 CXCR1/2 的强效抑制剂，它对 CXCR2 介导的细胞迁移具有微弱的抑制作用，IC50为 100 nM。它强烈阻断 CXCR1 介导的趋化性，IC50为 1 nM。
T23920	CX4338 CX-4338,CX 4338
	CX4338 is a CXCL8-mediated chemotaxis inhibitor.
T83702	E70K TFA
	E70K是一种抑制趋化因子(C-X-C)配体8 (CXCL8)与细胞膜外的糖胺聚糖(GAGs)之间相互作用的抑制剂。它对应于CXCL8 C末端GAG结合区的氨基酸序列，并在第70位上含有谷氨酸到赖氨酸的替换。在50 nM浓度下，E70K能够抑制初级人类中性粒细胞与人类脐静脉内皮细胞(HUVECs)的结合。当使用浓度范围为1至1,000 nM时，它能降低CXCL8诱导的初级人类中性粒细胞通过HMEC-1人类微血管内皮细胞层的跨内皮迁移。
T80525	E70K	CXCR	Autophagy; GPCR/G Protein; Immunology/Inflammation
	E70K是CXCL8 C端肽的变体，其第70位的谷氨酸被赖氨酸取代。该化合物能够降低炎症过程中中性粒细胞的粘附与迁移。
T61447	CXCR2 antagonist 4
	CXCR2 antagonist 4 (compound 7) is a highly potent antagonist that inhibits CXCR2 with an IC50 value of 0.13 μM. It also effectively inhibits the cytosolic calcium increase induced by CXCL8, with an IC50 value of 27 μM. CXCR2 antagonist 4 shows promising potential for anticancer research [1].
T80090	Lugdunin	Antibiotic	Microbiology/Virology
	Lugdunin是一种具有抗菌活性的肽类抗生素。该化合物能够通过破坏细菌细胞膜的电位来抑制革兰氏阳性菌的生长，特别是对金黄色葡萄球菌（Staphylococcus aureus）表现出高效能，有效降低其在皮肤和鼻腔的定植能力。此外，Lugdunin还能在人类角质形成细胞和小鼠皮肤中促进LL-37和CXCL8/MIP-2的表达。
T7130	Navarixin MK-7123,SCH 527123	CXCR	Autophagy; GPCR/G Protein; Immunology/Inflammation
	Navarixin (MK-7123) 是一种可口服的 CXCR1和 CXCR2变构拮抗剂，对猕猴 CXCR1的 Kd 值为 41 nM，对大小鼠和猕猴 CXCR2的 Kd 值分别为 0.20、0.20 和 0.08 nM。

化合物

Interleukin-8 (54-72) (human) TFA

Cat.No: T83712

Synonym: IL-8 (54-72),C-X-C Motif Chemokine Ligand (54-72),CXCL8 (54-72)

Cat.No: T5193

Synonym: GSK1325756

Target: CXCR

Cat.No: T4163

Synonym: DF 1681Y,Repertaxin,瑞帕利辛

Target: CXCR

Cat.No: T23920

Synonym: CX-4338,CX 4338

Cat.No: T83702

Cat.No: T80525

Target: CXCR

CXCR2 antagonist 4

Cat.No: T61447

Cat.No: T80090

Target: Antibiotic

Cat.No: T7130

Synonym: MK-7123,SCH 527123

Target: CXCR

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-04726	IL-8/CXCL8 Protein, Human, Recombinant (His) Interleukin-8,GCP1,MONAP,LECT,LYNAP,NAF,GCP-1,LUCT,...	Human	P. pastoris (Yeast)
	IL-8/CXCL8 Protein, Human, Recombinant (His) is expressed in yeast with His tag. The predicted molecular weight is 9.8 kDa and the accession number is A0A024RDA5.
TMPK-00480	IL-8/CXCL8 Protein, Cynomolgus, Recombinant (His) GCP/IL-8 protein IV,MDNCF,CXCL8,G...	Cynomolgus	HEK293 Cells
	Interleukin-8 (IL-8) has been revealed as a critical regulator of CNS function and development with participation in many CNS disorders including gliomas.Several promising approaches that target directly or indirectly IL-8 effects in gliomas are currently in progress while more-in-depth studies are needed to validate its biomarker role and elucidate the underlying molecular mechanisms.
TMPY-00472	IL-8/CXCL8 Protein, Human, Recombinant (aa 28-99) NAF,GCP1,NAP1,chemokine (C-X-C motif) ligand 8,Inte...	Human	E. coli
	IL-8/CXCL8 Protein, Human, Recombinant (aa 28-99) is expressed in E. coli expression system. The predicted molecular weight is 8.5 kDa and the accession number is A0A024RDA5.
TMPY-00754	IL-8/CXCL8 Protein, Human, Recombinant (aa 23-99) MONAP,MDNCF,NAP-1,白介素,NAP1,LUCT,chemokine (C-X-C motif) liga...	Human	HEK293 Cells
	IL-8/CXCL8 Protein, Human, Recombinant (aa 23-99) is expressed in HEK293 mammalian cells. The predicted molecular weight is 8 kDa and the accession number is A0A024RDA5.
TMPY-03480	IL-8/CXCL8 Protein, Rhesus, Recombinant 白介素,chemokine (C-X-C motif) ligand 8,白细胞介素	Rhesus	E. coli
	IL-8/CXCL8 Protein, Rhesus, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 9.3 kDa and the accession number is P67813.
TMPH-00376	IL-8/CXCL8 Protein, Chicken, Recombinant	Chicken	E. coli
	May be an autocrine factor that promotes the growth of fibroblasts and is involved in the neoplastic transformation of fibroblasts by v-Src. Chemotactic for peripheral blood mononuclear cells as well as for heterophils. IL-8/CXCL8 Protein, Chicken, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 9.4 kDa and the accession number is P08317.
TMPY-03022	IL-8/CXCL8 Protein, Canine, Recombinant chemokine (C-X-C motif) ligand 8	Canine	E. coli
	IL-8/CXCL8 Protein, Canine, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 9.2 kDa and the accession number is P41324.
TMPH-00375	IL-8/CXCL8 Protein, Chicken, Recombinant (His)	Chicken	E. coli
	May be an autocrine factor that promotes the growth of fibroblasts and is involved in the neoplastic transformation of fibroblasts by v-Src. Chemotactic for peripheral blood mononuclear cells as well as for heterophils. IL-8/CXCL8 Protein, Chicken, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 13.4 kDa and the accession number is P08317.
TMPY-00755	IL-8/CXCL8 Protein, Human, Recombinant (aa 28-99, hFc) chemokine (C-X-C motif) ligand 8,Interleukin-8<...	Human	HEK293 Cells
	IL-8/CXCL8 Protein, Human, Recombinant (aa 28-99, hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 35 kDa and the accession number is A0A024RDA5.
TMPY-00753	IL-8/CXCL8 Protein, Human, Recombinant (aa 23-99, hFc) LECT,MONAP,IL-8,LYNAP,白细胞介素,chemokine (C-X-C motif)...	Human	HEK293 Cells
	IL-8/CXCL8 Protein, Human, Recombinant (aa 23-99, hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 35.6 kDa and the accession number is A0A024RDA5.
TMPJ-00397	IL-17RA Protein, Human, Recombinant (His & Avi), Biotinylated CD217,IL17RA,interleukin 17 receptor A,IL17Rinterleukin-17 r...	Human	HEK293 Cells
	CD217, also known as Interleukin-17 receptor A, is a T cell expressed pleotropic cytokine with 866 amino acids in length. CD217 functions as receptors for IL17A and IL17F, it binds to IL17A with higher affinity than to IL17F and binds IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RC. It also binds heterodimers formed by IL17A and IL17F as part of a heterodimeric complex with IL17RC. The activation of IL17RA would lead to induction of expression of inflammatory chemokines...
TMPJ-01060	CXCL6 Protein, Human, Recombinant (His) SCYB6,Chemokine Alpha 3,CKA-3,GCP2,GCP-2,C-X-C Motif Chemoki...	Human	HEK293 Cells
	Chemokine (C-X-C-Motif) Ligand 6 (CXCL6) is a small cytokine belonging to the CXC chemokine family. It is a potent neutrophil chemotactic and activating factor and it exhibits extensive similarity to other CXC chemokines such as IL-8 and ENA-78. CXCL6 can promote the release of MMP-9 from granulocytes indicating its potential role as an inflammatory mediator. It functionally uses both of the IL-8/CXCL8 receptors to chemoattract neutrophils but that is structurally most related to epithelial cell...

重组蛋白

IL-8/CXCL8 Protein, Human, Recombinant (His)

Cat.No: TMPY-04726

Species: Human

Expression System: P. pastoris (Yeast)

IL-8/CXCL8 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00480

Species: Cynomolgus

Expression System: HEK293 Cells

IL-8/CXCL8 Protein, Human, Recombinant (aa 28-99)

Cat.No: TMPY-00472

Species: Human

Expression System: E. coli

IL-8/CXCL8 Protein, Human, Recombinant (aa 23-99)

Cat.No: TMPY-00754

Species: Human

Expression System: HEK293 Cells

IL-8/CXCL8 Protein, Rhesus, Recombinant

Cat.No: TMPY-03480

Species: Rhesus

Expression System: E. coli

IL-8/CXCL8 Protein, Chicken, Recombinant

Cat.No: TMPH-00376

Species: Chicken

Expression System: E. coli

IL-8/CXCL8 Protein, Canine, Recombinant

Cat.No: TMPY-03022

Species: Canine

Expression System: E. coli

IL-8/CXCL8 Protein, Chicken, Recombinant (His)

Cat.No: TMPH-00375

Species: Chicken

Expression System: E. coli

IL-8/CXCL8 Protein, Human, Recombinant (aa 28-99, hFc)

Cat.No: TMPY-00755

Species: Human

Expression System: HEK293 Cells

IL-8/CXCL8 Protein, Human, Recombinant (aa 23-99, hFc)

Cat.No: TMPY-00753

Species: Human

Expression System: HEK293 Cells

IL-17RA Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPJ-00397

Species: Human

Expression System: HEK293 Cells

CXCL6 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01060

Species: Human

Expression System: HEK293 Cells

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