Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Danirixin (GSK1325756) 是一种选择性可逆的CXCR2拮抗剂,抑制 CXCL8 的IC50值为 12.5 nM。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 797 | 现货 | ||
5 mg | ¥ 2,450 | 现货 | ||
10 mg | ¥ 3,480 | 现货 | ||
25 mg | ¥ 5,660 | 现货 | ||
50 mg | ¥ 7,880 | 现货 | ||
100 mg | ¥ 10,600 | 现货 | ||
500 mg | ¥ 21,300 | 待询 | ||
1 mL * 10 mM (in DMSO) | ¥ 2,570 | 现货 |
产品描述 | Danirixin (GSK1325756) is a potent antagonist of CXCR2 that inhibits IL-8 binding to CXCR2 (IC50: 12.5 nM). |
靶点活性 | CXCL8-CXCR2:12.5 nM (cell free) |
体内活性 | Systemic exposure following single doses of danirixin 10 mg, 25 mg, 50 mg, 100 mg, and 200 mg increased with increasing dose. Engagement of pharmacology was demonstrated as inhibition of ex-vivo CXCL1-induced CD11b expression on peripheral blood neutrophils when compared to placebo (approximately 50 % for 50 mg and 100 mg danirixin, and 72 % at 200 mg). There was a 37 % decrease in Cmax and a 16 % decrease in AUC (0-∞) following administration of danirixin in the presence of food. Cmax also decreased by 65 % when danirixin 100 mg was administered following omeprazole 40 mg once daily for 5 days [1]. |
别名 | GSK1325756 |
分子量 | 441.9 |
分子式 | C19H21ClFN3O4S |
CAS No. | 954126-98-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 8 mg/mL (18.10 mM), Sonification and heating are recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.263 mL | 11.3148 mL | 22.6296 mL | 56.5739 mL |
5 mM | 0.4526 mL | 2.263 mL | 4.5259 mL | 11.3148 mL | |
10 mM | 0.2263 mL | 1.1315 mL | 2.263 mL | 5.6574 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Danirixin 954126-98-8 Autophagy GPCR/G Protein Immunology/Inflammation CXCR Inhibitor inhibit GSK-1325756 GSK 1325756 CXC chemokine receptors GSK1325756 inhibitor