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Cat. No.	Product Name	Target	Signaling Pathways
T60464	COX-2-IN-20
	COX-2-IN-20 (Compound 5d) 是一种选择性口服活性的COX-2抑制剂（IC 50 = 17.9 nM），具有抗炎活性。
T21412	Ketorolac Toradol,Sprix,Acuvail,Macril,酮咯酸,Acular	COX	Immunology/Inflammation; Neuroscience
	Ketorolac (Acuvail) 是非甾体抗炎剂，是非选择性的COX 抑制剂，对 COX-1 和 COX-2 的IC50值分别为 20 和 120 nM。
T38240	2,6-Dichlorodiphenylamine	Antibacterial	Microbiology/Virology
	2,6-Dichlorodiphenylamine 是双氯芬酸钠的一种结构类似物，显示出抗白色念珠菌活性。2,6-Dichlorodiphenylamine 是非选择性抗炎剂，为COX 的抑制剂，在 CHO 细胞中，对人 COX-1 和 COX-2 的IC50分别为 4 和 1.3 nM。
T35610	2,5-dimethyl Celecoxib	Apoptosis; Wnt/beta-catenin; Prostaglandin Receptor	Apoptosis; Cytoskeletal Signaling; GPCR/G Protein; Immunology/Inflammation; Stem Cells
	2,5-dimethyl Celecoxib 是塞来昔布衍生物和微粒体前列腺素 E 合酶 1 (mPGES-1) 的靶向抑制剂，mPGES-1 是炎症介质 PGE2 合成途径中的关键酶。
T60496	Ketorolac hemicalcium
	Ketorolac (RS37619) hemicalcium 是一种非选择性的 COX 抑制剂，对 COX-1 的 IC50 为 20 nM，对 COX-2 的 IC50 为 120 nM。 Ketorolac hemicalcium 是一种非甾体类抗炎药 (NSAID)，可用作 0.5% 滴眼液，用于研究过敏性结膜炎、黄斑囊样水肿、术中瞳孔缩小和术后眼部炎症和疼痛等。 Ketorolac hemicalcium 也是一种可用于癌症研究的 DDX3 抑制剂 [1] [4]。
T71303	Flufenamic Acid-d4
	Flufenamic acid-d4 is intended for use as an internal standard for the quantification of flufenamic acid by GC- or LC-MS. Flufenamic acid is a non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor (IC50s = 3 and 9.3 µM for human COX-1 and COX-2, respectively). Flufenamic acid inhibits TNF-α-induced increases in COX-2 levels and NF-κB activation in HT-29 colon cancer cells in a concentration-dependent manner. It inhibits calcium influx induced by fMLP or A23187 in human polymorphonuclear...
T36671	C2 Phytoceramide (t18:0/2:0)
	C2 Phytoceramide is a bioactive semisynthetic sphingolipid that inhibits formyl peptide-induced oxidant release (IC50 = 0.38 μM) in suspended polymorphonuclear cells. It increases COX-2 protein levels 15-fold through ERK signaling. It induces death of keratinocytes (20% viability) with an ED50 value of 30 μM, the same concentration at which 35% of cells in a TUNEL assay are apoptotic. C2 Phytoceramide also has antiproliferative effects in CHO cells, with greater than 80% cytotoxicity achieved at...
TMIH-0290	Ketorolac-d5-P1
	Ketorolac-d5-P1 是 Ketorolac 的氘代化合物。Ketorolac 的 CAS 号为 74103-06-3。Ketorolac 是非甾体抗炎剂，是非选择性的COX抑制剂，对 COX-1 和 COX-2 的IC50值分别为 20 和 120 nM。
TMIH-0291	Ketorolac-d5-P2
	Ketorolac-d5-P2 是 Ketorolac 的氘代化合物。Ketorolac 的 CAS 号为 74103-06-3。Ketorolac 是非甾体抗炎剂，是非选择性的COX抑制剂，对 COX-1 和 COX-2 的IC50值分别为 20 和 120 nM。
T35881	Resolvin E2
	Resolvin E2 (RvE2) is a member of the specialized pro-resolving mediator (SPM) family of bioactive lipids.1It is produced from eicosapentaenoic acidviaan 18-HEPE intermediate, which is formed by aspirin-acetylated COX-2-mediated oxidation of EPA, by 5-lipoxygenase (5-LO) in human polymorphonuclear (PMN) neutrophils.2,3RvE2 (20 ng/animal) inhibits increases in inflammatory exudate neutrophil infiltration in a mouse model of peritonitis induced by zymosan A .3Hepatic RvE2 levels are increased in m...
T35789	Palmitic acid-1-13C
	Palmitic acid-13C is intended for use as an internal standard for the quantification of palmitic acid by GC- or LC-MS. Palmitic acid is a 16-carbon saturated fatty acid. It comprises approximately 25% of human total plasma lipids.1 It increases protein levels of COX-2 in RAW 264.7 cells when used at a concentration of 75 μM.2 Palmitic acid is involved in the acylation of proteins to anchor membrane-bound proteins to the lipid bilayer.2,3,4,5,6 \|1. Santos, M.J., López-Jurado, M., Llopis, J., et a...
T36176	AMK (hydrochloride)
	AMK is an active metabolite of the neurohormone melatonin .1,2,3,4It is formed from melatoninviathe metabolic intermediate AFMK that is then deformylated by catalase or formamidase.5,6AMK scavenges singlet oxygenin vitrowhen used at a concentration of 200 μM.1It inhibits the epinephrine- and arachidonic acid-induced production of prostaglandin E2and PGD2in ovine seminal vesicle microsomes in a concentration- and time-dependent manner, as well as LPS-induced increases in COX-2 levels in RAW 264.7...
T35791	Palmitic acid-13C
	Palmitic acid-13C is intended for use as an internal standard for the quantification of palmitic acid by GC- or LC-MS. Palmitic acid-13C contains 13C at the C2 position and has been used in the study of free fatty acid incorporation into phospholipid fatty acids in soil microbes.1 Palmitic acid is a 16-carbon saturated fatty acid. It comprises approximately 25% of human total plasma lipids.2 It increases protein levels of COX-2 in RAW 264.7 cells when used at a concentration of 75 μM.3 Palmitic ...

化合物

Cat.No: T60464

Cat.No: T21412

Synonym: Toradol,Sprix,Acuvail,Macril,酮咯酸,Acular

Target: COX

2,6-Dichlorodiphenylamine

Cat.No: T38240

Target: Antibacterial

2,5-dimethyl Celecoxib

Cat.No: T35610

Target: Apoptosis, Wnt/beta-catenin, Prostaglandin Receptor

Ketorolac hemicalcium

Cat.No: T60496

Flufenamic Acid-d4

Cat.No: T71303

C2 Phytoceramide (t18:0/2:0)

Cat.No: T36671

Ketorolac-d5-P1

Cat.No: TMIH-0290

Ketorolac-d5-P2

Cat.No: TMIH-0291

Cat.No: T35881

Palmitic acid-1-13C

Cat.No: T35789

AMK (hydrochloride)

Cat.No: T36176

Palmitic acid-13C

Cat.No: T35791

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