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Cat. No.	Product Name	Target	Signaling Pathways
T10746	CDK9-IN-8	CDK	Cell Cycle/Checkpoint
	CDK9-IN-8 is a highly potent and selective CDK9 inhibitor (IC50: 12 nM).
T10742	CDK9-IN-10	CDK	Cell Cycle/Checkpoint
	CDK9-IN-10 是一种有效的 CDK9 抑制剂。CDK9-IN-10 是 PROTAC CDK9 degrader-2 的配体。
T10745	CDK9-IN-7	CDK	Cell Cycle/Checkpoint
	CDK9-IN-7 (compound 21e) 是一种高效选择性的，具有口服活性的 CDK9/cyclin T 抑制剂 (IC50=11 nM)，与抑制其他 CDK 相比更有效 (CDK4/cyclinD=148 nM; CDK6/cyclinD=145 nM)。CDK9-IN-7 具有抗癌活性并没有明显的毒性。CDK9-IN-7 诱导非小细胞肺癌 (NSCLC) 细胞凋亡，在 G2 期阻滞细胞周期，并具有抑制非小细胞肺癌干细胞特性。
T10747	CDK9-IN-9	CDK	Cell Cycle/Checkpoint
	CDK9-IN-9 is a potent and selective CDK9 inhibitor (IC50: 1.8 nM) with anti-cancer activity. It inhibits CDK2 (IC50: 155 nM).
T14918	CDK9-IN-2 N2'-(反式-4-氨基环己基)-5'-氯-N6-[(3-氟苯基)甲基]-[2,4'-联吡啶]-2',6-二胺	Others; CDK	Cell Cycle/Checkpoint; Others
	CDK9-IN-2 是一种特异性CDK9抑制剂。它在 A2058 皮肤细胞系（72 小时）和 H929 多发性骨髓瘤细胞系（72小时）的IC50分别为 7 nM 和 5 nM。
T39354	CDK9-IN-12 CDK9-IN-12
	CDK9-IN-12 displays the optimal CDK9 inhibitory activity with an IC 50 value of 5.41 nM.
T10743	CDK9-IN-11	CDK	Cell Cycle/Checkpoint
	CDK9-IN-11 是一种有效的CDK9抑制剂，可作为 PROTAC CDK9 Degrader-1 的配体。
T10741	CDK9-IN-1	CDK	Cell Cycle/Checkpoint
	CDK9-IN-1 is a novel, selective CDK9 inhibitor for the treatment of HIV infection (IC50: 39 nM for CDK9/CycT1).
T118066	CDK9 inhibitor HH1 8019-9719	CDK	Cell Cycle/Checkpoint
	CDK9 inhibitor HH1 (8019-9719) 是人类 CDK2-cyclin A2复合物的抑制剂，IC50为2 μM。
T36744	CDK9 Antagonist-1 CDK9 Antagonist-1
	CDK9 Antagonist-1 (compounds 11c) is a potent and selective CDK9 degrader based on PROTAC, with an IC50 of 17 μM in MCF-7 cell lines. Natural product Wogonin binds ubiquitin E3 ligase cereblon (CRBN) via a linker to form PROTAC[1]. CDK9\|17 μM (IC50, MCF-7 cells) [1]. Bian J , et al. Discovery of Wogonin-based PROTACs against CDK9 and capable of achieving antitumor activity. Bioorg Chem. 2018 Dec;81:373-381.
T39997	PROTAC CDK9 ligand-1 PROTAC CDK9 ligand-1
	PROTAC CDK9 ligand-1 is a CDK9 ligand that can be used in the synthesis of PROTACs.
T39996	PROTAC CDK9 degrader-4 PROTAC CDK9 degrader-4
	PROTAC CDK9 degrader-4 is a potent and efficacious chemical compound designed specifically to degrade CDK9, a protein involved in transcription regulation. This compound effectively targets and reduces the levels of CDK9, thereby modulating transcriptional activity.
T5438	PROTAC CDK9 Degrader-1	CDK	Cell Cycle/Checkpoint
	PROTAC CDK9 Degrader-1 是一种选择性 CDK9 降解剂，是由Cereblon 配体和CDK 配体相连的PROTAC。
T74852	PROTAC CDK9 degrader-6	CDK	Cell Cycle/Checkpoint
	PROTACCDK9 degrader-6 是靶向CDK9的特异性PROTAC分子，能通过蛋白酶体介导的机制实现CDK9的降解。该化合物针对CDK942与CDK955异构体的DC50分别为0.03 μM和0.05 μM。
T70400	CDK9/CycT1-IN-93
	CDK9/CycT1-IN-93 is a highly specific, ATP-competitive inhibitor of CDK9/CycT1 with antiviral activity.
T74851	PROTAC CDK9 degrader-5	PROTACs	PROTAC
	PROTACCDK9 degrader-5为针对CDK9的特异性PROTAC分子，通过蛋白酶体途径介导CDK9的降解作用。针对CDK942和CDK955异构体，其DC50值分别为0.10 μM和0.14 μM。
T74853	PROTAC CDK9 degrader-7
	PROTACCDK9 degrader-7 是一种特异性靶向CDK9的PROTAC。PROTACCDK9 degrader-7 通过蛋白酶体介导CDK9降解。
T78928	PROTAC CDK9 degrader-8	PROTACs	PROTAC
	PROTACCDK9degrader-8 (化合物21) 是具有0.01 μM IC50值的高效PROTAC CDK9降解剂，适用于癌症研究领域。
T63851	CDK9/10/GSK3β-IN-1
	CDK9/10/GSK3β-IN-1 是一种激酶抑制剂 (Flavopiridol 类似物)，能有效抑制 HsGSK3β、HsCDK9/CyclinT、HsCDK5/p25 和 HsCDK2/CyclinA，其 IC50 值分别为 59 nM、64 nM、1.093 μM 和 1.725 μM。CDK9/10/GSK3β-IN-1 表现出相当或高于 Flavopiridol 的抗癌细胞活性，在体外对多达七种癌细胞系表现出高抗增殖活性。
T79904	PROTAC CDK9/CycT1 Degrader-2	CDK	Cell Cycle/Checkpoint
	PROTACCDK9/CycT1 Degrader-2 对CDK9表现出较高的抑制效能，具有一个IC50值为45 nM。
T74707	PROTAC FLT3/CDK9 degrader-1
	PROTACFLT3/CDK9 degrader-1 是一种有效的FLT3和CDK9双PROTAC 降解剂。PROTACFLT3/CDK9 degrader-1 诱导细胞凋亡 (Apoptosis) 并有效降解靶蛋白FLT3和 CDK9。PROTACFLT3/CDK9 degrader-1具有研究 FLT3-ITD 突变型 AML 的潜力。
T79631	CDK9-IN-26	CDK	Cell Cycle/Checkpoint
	CDK9-IN-26 (化合物1d) 为CDK9抑制剂，具有0.18 µM的IC50值。
T40353	CDK7/9-IN-1 CDK7/9-IN-1
	CDK7/9-IN-1 is a specific inhibitor of cyclin-dependent kinases 7/9 (CDK7/9). It specifically targets CDK7, while also displaying inhibitory activity against CDK9. CDK7/9-IN-1 demonstrates excellent inhibitory potency against CDK7, with IC50 values of 0.0656 μM and 0.00574 μM without pre-incubation and after 3 hours pre-incubation, respectively. Furthermore, CDK7/9-IN-1 inhibits CDK9 with an IC50 of 2.14 μM after 3 hours pre-incubation. Its application in cancer research makes it valuable for su...
T36743	CDK7/9 tide
	CDK7/9 tide is peptide substrate for CDK7 or CDK9[1]. [1]. Robert T, et, al. Development of a CDK10/CycM in vitro Kinase Screening Assay and Identification of First Small-Molecule Inhibitors. Front Chem. 2020 Feb 27; 8:147.
T40047	CDK6/9-IN-1 CDK6/9-IN-1
	CDK6/9-IN-1 (compound 66) is a potent dual inhibitor of CDK 6 and CDK 9 that can be administered orally. It exhibits inhibitory activity with IC 50 values of 40.5 nM and 39.5 nM against CDK6 and CDK9, respectively.
T70897	Zotiraciclib HCl
	Zotiraciclib, also known as TG02 and SB1317, is a novel small molecule potent CDK/JAK2/FLT3 inhibitor. Zotiraciclib may be useful for the treatment of cancer that crosses the blood brain barrier and acts by depleting Myc through the inhibition of cyclin-dependent kinase 9 (CDK9). It is one of a number of CDK inhibitors under investigation; others targeting CDK9 for the treatment of acute myeloid leukemia include alvocidib and atuveciclib. Myc overexpression is a known factor in many cancers, w...
T70988	Ibulocydine
	Ibulocydine is a potent CDK inhibitor. Ibulocydine has high activity against Cdk7/cyclin H/Mat1 and Cdk9/cyclin T. Ibulocydine inhibited the growth of HCC cells more effectively than other Cdk inhibitors, including olomoucine and roscovitine, whereas ibulocydine as well as the other Cdk inhibitors and BMK-Y101 minimally influenced the growth of normal hepatocyte cells. Ibulocydine induced apoptosis in HCC cells, most likely by inhibiting Cdk7 and Cdk9. In vitro treatment of HCC cells with ibuloc...

化合物

Cat.No: T10746

Target: CDK

Cat.No: T10742

Target: CDK

Cat.No: T10745

Target: CDK

Cat.No: T10747

Target: CDK

Cat.No: T14918

Synonym: N2'-(反式-4-氨基环己基)-5'-氯-N6-[(3-氟苯基)甲基]-[2,4'-联吡啶]-2',6-二胺

Target: Others, CDK

Cat.No: T39354

Synonym: CDK9-IN-12

Cat.No: T10743

Target: CDK

Cat.No: T10741

Target: CDK

CDK9 inhibitor HH1

Cat.No: T118066

Synonym: 8019-9719

Target: CDK

CDK9 Antagonist-1

Cat.No: T36744

Synonym: CDK9 Antagonist-1

PROTAC CDK9 ligand-1

Cat.No: T39997

Synonym: PROTAC CDK9 ligand-1

PROTAC CDK9 degrader-4

Cat.No: T39996

Synonym: PROTAC CDK9 degrader-4

PROTAC CDK9 Degrader-1

Cat.No: T5438

Target: CDK

PROTAC CDK9 degrader-6

Cat.No: T74852

Target: CDK

CDK9/CycT1-IN-93

Cat.No: T70400

PROTAC CDK9 degrader-5

Cat.No: T74851

Target: PROTACs

PROTAC CDK9 degrader-7

Cat.No: T74853

PROTAC CDK9 degrader-8

Cat.No: T78928

Target: PROTACs

CDK9/10/GSK3β-IN-1

Cat.No: T63851

PROTAC CDK9/CycT1 Degrader-2

Cat.No: T79904

Target: CDK

PROTAC FLT3/CDK9 degrader-1

Cat.No: T74707

Cat.No: T79631

Target: CDK

Cat.No: T40353

Synonym: CDK7/9-IN-1

Cat.No: T36743

Cat.No: T40047

Synonym: CDK6/9-IN-1

Zotiraciclib HCl

Cat.No: T70897

Cat.No: T70988

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