Cat. No. | Product Name | Target | Signaling Pathways |
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T61362 |
CDK5-IN-3
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CDK5-IN-3 (compound 11) is a highly potent and selective inhibitor of CDK5, demonstrating significant inhibition with IC50 values of 0.6 nM and 18 nM for CDK5/p25 and CDK2/CycA, respectively. This compound holds promise for further investigation in the context of autosomal dominant polycystic kidney disease (ADPKD) research [1]. | |||
T35555 |
GSK-3/CDK5/CDK2-IN-1
GSK-3/CDK5/CDK2-IN-1 |
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GSK-3/CDK5/CDK2-IN-1 is an imidazole derivative compound that inhibits cdk5, cdk2, and GSK-3.it has demonstrated applications in cancer research and the study of neurodegenerative diseases [1]. | |||
T77341 |
GSK-3 inhibitor 4
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GSK-3; CDK | Cell Cycle/Checkpoint; PI3K/Akt/mTOR signaling; Stem Cells |
GSK-3 inhibitor 4 是一种具有口服活性和脑渗透性的 GSK-3,CDK2 和 CDK5 三重抑制剂,对 GSK-3β,GSK-3α,CDK2 和 CDK5 具有抑制作用,IC50 值分别为 0.56 nM ,0.45 nM ,0.47 μM,0.68 μM。GSK-3 inhibitor 4 可有效降低 Tau protein 水平。GSK-3 inhibitor 4 可用于研究阿尔茨海默症 。 | |||
T63933 | CDK1-IN-3 | ||
CDK1-IN-3 (8g) 是一种选择性的 CDK1 抑制剂,能够作用于 CDK1 (IC50: 36.8 nM),CDK2 (IC50: 305.17 nM) 和 CDK5 (IC50: 369.37 nM)。CDK1-IN-3 能够影响细胞周期,进而抑制癌细胞的生长,能够用于研究癌症。 |