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Search Results for " cd73 "

Targets Recommended: CD73 CD73

33

抑制剂 & 化合物

7

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T10721	CD73-IN-1	CD73	Immunology/Inflammation
	CD73-IN-1 是一种具有抗癌活性的 CD73 抑制剂。
T8875	CD73-IN-3 EX-A4254,LY-3475070	CD73	Immunology/Inflammation
	CD73-IN-3 (LY-3475070) 是一种有效的选择性 CD73 抑制剂，IC50 为 28 nM，具有癌症的研究潜力。
T9210	CD73-IN-4	CD73	Immunology/Inflammation
	CD73-IN-4 是高选择性的亚甲基膦酸 CD73抑制剂，对人 CD73 作用的 IC50值为 2.6 nM，在癌症免疫学中具有研究潜力。
T40033	CD73-IN-5 CD73-IN-5
	CD73-IN-5 is a highly potent and selective small molecule inhibitor of CD73, demonstrating non-nucleotide characteristics. It exerts its inhibitory effects with a remarkable IC50 value of 19 nM.
T61691	CD73-IN-6
	CD73-IN-6, serves as a potent inhibitor of CD73. This compound finds utility in cancer research [1].
T61000	CD73-IN-10
	CD73-IN-10 可用于肿瘤相关疾病药物的制备。CD73-IN-10 是 CD73的有效抑制剂，能够催化细胞外5'-磷酸腺苷 (5'-AMP) 产生腺苷。腺苷具有诱导免疫抑制的作用，能够促进肿瘤增殖和/或转移。
T60844	CD73-IN-9
	CD73-IN-9 是 CD73 的有效抑制剂，可用于制备治疗肿瘤相关疾病的药物。CD73 可以催化细胞外5'-磷酸腺苷 (5'-AMP) 产生腺苷。腺苷能够诱导免疫抑制作用，并且促进肿瘤增殖和/或转移。
T63128	CD73-IN-2
	CD73-IN-2 是一种 CD73 的有效抑制剂 (IC50: 0.09 nM)。
T61053	CD73-IN-11
	CD73-IN-11 可用于肿瘤相关疾病的药物制备。CD73-IN-11 是 CD73的有效抑制剂。CD73 可以催化细胞外5'-磷酸腺苷 (5'-AMP) 产生腺苷，从而诱导免疫抑制并促进肿瘤增殖和/或转移。
T10216	AB-680	CD73	Immunology/Inflammation
	AB-680 是一种选择性可逆的CD73(胞外核苷酸酶) 抑制剂，具有抗肿瘤活性。它对 hCD73 的Ki 值为 4.9 pM，对其选择性是对相关胞外核苷酸酶 CD39 的 10000 多倍。
T60779	CD73-IN-13
	CD73-IN-13 可用于制备肿瘤相关疾病的药物。CD73-IN-13 是CD73的有效抑制剂，CD73 与肿瘤生长、血管生成和转移密切相关。
T61118	CD73-IN-12
	CD73-IN-12 is a highly effective CD73 inhibitor that displays strong potential in tumor suppression. CD73, an enzyme intricately linked to tumor development, angiogenesis, and metastasis, is significantly inhibited by CD73-IN-12. This compound holds promise in the formulation of therapeutic medications targeting tumor-related diseases[1].
T61090	CD73-IN-8
	CD73-IN-8, a potent CD73 inhibitor, prevents the catalytic activity of CD73, an enzyme responsible for converting extracellular 5'-phosphate adenosine (5'-AMP) to adenosine. Adenosine, once produced, can induce immunosuppressive effects and facilitate tumor proliferation and/or metastasis. Therefore, CD73-IN-8 holds promise in the development of therapeutic interventions for tumor-related diseases[1].
T60599	CD73-IN-7
	CD73-IN-7 是一种有效的CD73抑制剂，可用于制备治疗肿瘤相关疾病的药物。CD73 催化细胞外5'-磷酸腺苷 (5'-AMP) 产生腺苷，从而诱导免疫抑制作用并促进肿瘤增殖和/或转移。
T12569L	PSB-12379 ditriethylamine salt	CD73	Immunology/Inflammation
	PSB-12379 ditriethylamine salt 是一种核苷酸类似物，是一种有效的 Ecto-5'-Nucleotidase (CD73) 抑制剂，Kis 值为 9.03 nM (鼠) 和 2.21 nM (人)。
T76735	Mupadolimab CPI-006	CD73	Immunology/Inflammation
	Mupadolimab (CPI-006) 是一种人源化 FcγR 结合缺陷型 IgG1 抗 CD73抗体，具有潜在的抗癌活性，可激活 CD73POS B 细胞。
T22392	OP-5244	Others	Others
	OP-5244 has comparable potency to bisphosphonic acid series and targets CD73.
T12008	MethADP Adenosine 5'-(α,β-methylene)diphosphate	Others	Others
	MethADP is a specific inhibitor of CD73.
T12569	PSB-12379	Others	Others
	PSB-12379 is a potent inhibitor of Ecto-5'-Nucleotidase (CD73)(Kis of 9.03 nM (rat) and 2.21 nM (human)).
T12007	MethADP sodium salt	Others	Others
	MethADP is a specific CD73 inhibitor.
T76695	Oleclumab
	Oleclumab (MEDI9447) 是一种人 IgG1λ 抗CD73单克隆抗体，可抑制CD73功能。Oleclumab 具有抗肿瘤活性。
T71538	AMPCP
	AMPCP is an Ecto-5'-nucleotidase (CD73) inhibitor.
T76214	5′-Nucleotidase
	5′-Nucleotidase (CD73) 是一种作为胞外酶存在的内在膜糖蛋白。5′-Nucleotidase 催化 5-核苷酸水解成相应的核苷。
T22411	PSB-12489	Others	Others
	PSB-12489 is an optimized inhibitor of CD73.
T73886	AB-680 ammonium
	AB-680 ammonium 是一种有效、可逆、选择性的 CD73(胞外核苷酸酶) 抑制剂，对 hCD73 的Ki 值为 4.9 pM，对其选择性是对相关胞外核苷酸酶CD39的 10000 多倍。具有抗肿瘤活性。
T77155	Dalutrafusp alfa
	Dalutrafusp alfa (AGEN-1423; GS-1423) 为针对CD73与TGF-β的特异性双功能抗体，涉及免疫抑制路径。
T80603	Dresbuxelimab AK-119	CD73	Immunology/Inflammation
	Dresbuxelimab (AK-119) 为靶向CD73的IgG-κ型单克隆抗体，常用CHO（中国仓鼠卵巢）细胞作为表达系统。
T64019	ZM514
	ZM514 是 CD73 的有效抑制剂，能够作用于 hCD73 (IC50: 1.39 μM) 和 mCD73 (IC50: 14.65 μM)。ZM514 具有较低的细胞毒性，能够用于进行抗癌的研究。
T73628	PSB-12379 disodium
	PSB-12379 disodium 是一种核苷类似物，是一种有效的 Ecto-5'-Nucleotidase(CD73) 抑制剂，Kis 值为 9.03 nM (鼠) 和 2.21 nM (人)。
T76730	Uliledlimab
	Uliledlimab 是一种有效的抗 CD73人源单克隆抗体。Uliledlimab 抑制胞外单磷酸腺苷 (AMP) 向腺苷的转化。Uliledlimab 可用于癌症的研究。
T63956	OP-5244 sodium
	OP-5244 sodium 是有效的、口服具有活力的 CD73 抑制剂 (IC50: 0.25 nM)。OP-5244 sodium 能够阻断腺苷的产生，进而逆转免疫抑制作用，对癌症表现出研究潜力。
T74865	BK50164
	BK50164 是一种有效的CD73抑制剂，IC50值为 13.089 µM。BK50164 与 CD99 结合KD 值为 1.5 µM。BK50164 显示抗增殖活性。BK50164 诱导细胞凋亡 (Apoptosis) 和细胞周期停滞在 Sub-G1 阶段。
T35573	Adenosine 5’-methylenediphosphate (hydrate)
	Adenosine 5’-methylenediphosphate is an inhibitor of ecto-5’-nucleotidase, also known as CD73, with a Kivalue of 37 nM.1It inhibits cAMP accumulation induced by adenosine 5’-monophosphate , adenosine 5’-diphosphate , or adenosine 5’-triphosphate but not adenosine in VA-13 human fibroblasts when used at a concentration of 100 μM. Adenosine 5’-methylenediphosphate reduces proliferation of U138MG glioma cells, as well as inhibits the invasion and migration of MHCC97H hepatocellular carcinoma (HCC) ...

化合物

Cat.No: T10721

Target: CD73

Cat.No: T8875

Synonym: EX-A4254,LY-3475070

Target: CD73

Cat.No: T9210

Target: CD73

Cat.No: T40033

Synonym: CD73-IN-5

Cat.No: T61691

Cat.No: T61000

Cat.No: T60844

Cat.No: T63128

Cat.No: T61053

Cat.No: T10216

Target: CD73

Cat.No: T60779

Cat.No: T61118

Cat.No: T61090

Cat.No: T60599

PSB-12379 ditriethylamine salt

Cat.No: T12569L

Target: CD73

Cat.No: T76735

Synonym: CPI-006

Target: CD73

Cat.No: T22392

Target: Others

Cat.No: T12008

Synonym: Adenosine 5'-(α,β-methylene)diphosphate

Target: Others

Cat.No: T12569

Target: Others

MethADP sodium salt

Cat.No: T12007

Target: Others

Cat.No: T76695

Cat.No: T71538

5′-Nucleotidase

Cat.No: T76214

Cat.No: T22411

Target: Others

AB-680 ammonium

Cat.No: T73886

Dalutrafusp alfa

Cat.No: T77155

Cat.No: T80603

Synonym: AK-119

Target: CD73

Cat.No: T64019

PSB-12379 disodium

Cat.No: T73628

Cat.No: T76730

Cat.No: T63956

Cat.No: T74865

Adenosine 5’-methylenediphosphate (hydrate)

Cat.No: T35573

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-03377	CD73 Protein, Cynomolgus, Recombinant (His) 5'-nucleotidase, ecto (CD73)	Cynomolgus	HEK293 Cells
	CD73 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 59.2 kDa and the accession number is EHH53214.1.
TMPY-01342	CD73 Protein, Mouse, Recombinant (His) CD73,AI447961,2210401F01Rik,NT,5'-nucleoti...	Mouse	HEK293 Cells
	CD73 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 59.4 kDa and the accession number is Q0VEE0.
TMPY-03540	CD73 Protein, Rat, Recombinant (His) 5'-nucleotidase, ecto (CD73)	Rat	HEK293 Cells
	CD73 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 59.4 kDa and the accession number is Q66HL0.
TMPY-01851	CD73 Protein, Human, Recombinant (His) eN,NT5,E5NT,NT,5'-nucleotidase, ecto (CD73...	Human	HEK293 Cells
	CD73 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 59.2 kDa and the accession number is P21589-1.
TMPY-05454	CD73 Protein, Human, Recombinant (His), Biotinylated E5NT,eN,NT,NT5,5'-nucleotidase, ecto (CD73...	Human	HEK293 Cells
	CD73 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 59.2 kDa and the accession number is P21589-1.
TMPY-05580	CD73 Protein, Human, Recombinant (hFc) NT,CALJA,5'-nucleotidase, ecto (CD73),eN,e...	Human	HEK293 Cells
	CD73 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 84.5 kDa and the accession number is P21589-1.
TMPY-06907	CD73 Protein, Human, Recombinant (His & Avi), Biotinylated E5NT,NTE,CD73,NT5,5'-nucleotidase, ecto (<...	Human	HEK293 Cells
	CD73 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 61.04 kDa and the accession number is NP_002517.1.

重组蛋白

CD73 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPY-03377

Species: Cynomolgus

Expression System: HEK293 Cells

CD73 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-01342

Species: Mouse

Expression System: HEK293 Cells

CD73 Protein, Rat, Recombinant (His)

Cat.No: TMPY-03540

Species: Rat

Expression System: HEK293 Cells

CD73 Protein, Human, Recombinant (His)

Cat.No: TMPY-01851

Species: Human

Expression System: HEK293 Cells

CD73 Protein, Human, Recombinant (His), Biotinylated

Cat.No: TMPY-05454

Species: Human

Expression System: HEK293 Cells

CD73 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-05580

Species: Human

Expression System: HEK293 Cells

CD73 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPY-06907

Species: Human

Expression System: HEK293 Cells

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