Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T12404 |
CCK-A receptor inhibitor 1
|
cholecystokinin | GPCR/G Protein |
CCK-A receptor inhibitor 1 是一种有效的缩胆囊素 A (CCK-A) 受体抑制剂(IC50:340 nM)。CCK-A receptor inhibitor 1 可用于研究与消化系统相关的疾病。 | |||
TP1197 |
Sincalide
SQ19844,辛卡利特,CCK-8,Cholecystokinin octapeptide |
Others | Others |
Sincalide (CCK-8) 是一种速效的胆囊收缩素的氨基酸多肽激素类似物,可在胆囊造影术中静脉使用。它的肝胆生理作用是增加胆汁的分泌,使胆囊收缩并使 Oddi 的括约肌松弛,从而使胆汁排入十二指肠。它是一种通过注射促进胆囊收缩并帮助诊断胆囊和胰腺疾病的药物。 | |||
T13261 |
CCK-B Receptor Antagonist 1
|
Others | Others |
CCK-B Receptor Antagonist 1 is a cholecystokinin B (CCK-B) receptor agonist and has the potential of reducing the secretion of gastric acid. | |||
T10707 |
CCK-B Receptor Antagonist 2
|
Others | Others |
CCK-B Receptor Antagonist 2 is a potent and orally active antagonist of Gastrin/CCK-B (IC50: 0.43 nM). It also inhibits gastrin/CCK-A activity (IC50: 1.82 μM). | |||
T1052 |
Proglumide
二丙谷酰胺 |
cholecystokinin | GPCR/G Protein |
Proglumide (Binoside) 是一种非肽的、口服具有活性的胆囊收缩素(CCK)-A/B 受体拮抗剂。它能够选择性阻断 CCK 在中枢神经系统中的作用。它能够抑制胃分泌,具有保护胃十二指肠粘膜的能力,并表现出抗癫痫和抗氧化活性。 | |||
TQ0062 |
Nastorazepide
Z-360 |
cholecystokinin | GPCR/G Protein |
Nastorazepide 是一种选择性的、口服有效的1,5-苯并二氮杂环衍生物胃泌素/胆囊收缩素2(CCK-2)受体拮抗剂,具有抗肿瘤的潜能。 | |||
T2312 |
Loxiglumide
CR-1505,氯谷胺 |
cholecystokinin | GPCR/G Protein |
Loxiglumide (CR-1505) 是一种缩胆囊素受体拮抗剂。 | |||
T4579 |
Pentagastrin
五肽胃泌素,ICI-50123 |
Others; cholecystokinin | GPCR/G Protein; Others |
Pentagastrin (ICI-50123) 是一种选择性的胆囊收缩素 B(CCKB) 受体激动剂,IC50=11 nM。它能够增强胃粘膜对酸的防御机制,并保护胃粘膜免受损伤。 | |||
T14932 |
Ceruletide
Cerulein,Caerulein,雨蛙素,FI-6934 |
cholecystokinin | GPCR/G Protein |
Ceruletide (Caerulein) 是一种十肽,是一种安全有效的胆囊收缩剂,是一种胆囊收缩素受体激动剂,对胆囊肌肉和胆管有直接的痉挛性作用。 | |||
T9343 |
N-Cbz-DL-tryptophan
|
cholecystokinin | GPCR/G Protein |
N-Cbz-DL-tryptophan 是一种胆囊收缩素受体拮抗剂,可消除离体心脏对 CCK-8 的反应。 | |||
TP1931L1 |
[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P acetate
[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P acetate(96736-12-8 free base) |
cholecystokinin | GPCR/G Protein |
[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P acetate ([D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P acetate (96736-12-8 free base)) 是广谱神经肽反向激动剂和拮抗剂。 ghrelin 受体的强效完全反向激动剂(EC50 = 5.2 nM);减少组成型生长素释放肽受体信号传导。它也是速激肽、缓激肽、CCK 和铃蟾肽受体的拮抗剂。在体外诱导细胞凋亡并抑制癌细胞生长。 | |||
T15101 |
Devazepide
L-364,718,地伐西匹,MK-329 |
Others | Others |
Devazepide is a competitive and orally active nonpeptide antagonist of cholecystokinin (CCK) receptor (IC50s: 81 pM, 45 pM, and 245 nM for rat pancreatic, bovine gallbladder and guinea pig brain CCK receptors, respectively). | |||
T22666 |
CI-988
CI 988 |
Others | Others |
CCK2 (CCK-B) receptor antagonist | |||
T27014 |
CI-1015
CI1015,CI 1015,PD 144598 |
||
CI-1015 is a CCK-B receptor antagonist with oral activity. | |||
T13084 | Tarazepide | Others | Others |
Tarazepide is a potent and specific antagonist of CCK-A receptor. | |||
T29502 |
A 70874
A-70874,A70874 |
||
A70874 has high selectivity and potency for cholecystokinin (CCK) a receptor. | |||
T28340 |
PD-135666
PD 135666 |
||
PD-135666 is an antagonist of CCK receptor. | |||
T28342 |
PD-149164
PD 149164,PD149164 |
||
PD-149164 is an agonist of the CCK-A receptor. | |||
T23886 |
Cholecystokinin (27-32)-amide
Cholecystokinin (27-32)-NH2 |
||
Cholecystokinin (27-32)-amide is a CCK receptor antagonist. | |||
T26483 |
A-65186
A65186 |
||
A 65186 is a Type A Cholecystokinin (CCK) receptor antagonist. | |||
T27900 |
LY 219057
LY-219057,LY219057 |
||
LY 219057 is a potent, competitive, and specific antagonist of CCK receptor on the exocrine pancreas. | |||
T27774 |
L-740093
L 740093 |
||
L-740093 is a specific antagonist of CCK-B receptor. | |||
T28331 |
PD 136450
Cam1189,PD136450,Cam-1189,PD-136450,Cam 1189 |
||
Cholecystokinin type B receptor antagonist PD-136,450 is a partial secretory agonist in the stomach and a full agonist in the pancreas of the rat. Gastrin (cholecystokinin type B (CCK-B)) receptor antagonists may help to elucidate the physiological role o | |||
T25553 |
Jmv 332
Jmv-332,Jmv332 |
||
Jmv 332 is a cyclic analog of the C-terminal hexapeptide of CCK. It is a CCK/gastrin receptor agonist. | |||
T17274 |
YM022
|
CCR | Immunology/Inflammation; Microbiology/Virology |
YM022 is a highly effective and selective gastrin/cholecystokinin (CCK)-B receptor antagonist. YM022 can inhibit gastrin-induced gastric acid secretion and histidine decarboxylase activation in vivo. YM022 shows the Ki values of 68 pM and 63 nM for CCK-B and CCK-A receptor, respectively. | |||
T62039 | L-365260 hemihydrate | ||
L-365260 hemihydrate 是选择性的、具有口服活性的非肽胃泌素和脑胆囊收缩素受体 (CCK-B) 拮抗剂,Kis 值分别为 1.9 nM 和 2.0 nM。L-365260 hemihydrate 以竞争性方式与豚鼠胃泌素和脑 CCK 受体相互作用。 | |||
T27772 |
L-736380
L-736,380,L 736380,L736,380,L 736,380 |
||
L-736380 is a CCK-B receptor antagonist. L-736,380 dose-dependently inhibited gastric acid secretion in anesthetized rats (ID(50), 0.064 mg/kg) and ex vivo binding of [(125)I]CCK-8S in BKTO mice brain membranes (ED(50), 1.7 mg/kg). | |||
TP1931 |
[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P
|
||
Broad spectrum neuropeptide inverse agonist and antagonist. Potent full inverse agonist for the ghrelin receptor (EC50 = 5.2 nM); diminishes constitutive ghrelin receptor signaling. Also antagonist at tachykinin, bradykinin, CCK and bombesin receptors. In | |||
T14932L |
Ceruletide Ammonium acetate
FI-6934 Ammonium acetate,Caerulein Ammonium acetate,Ceruletide Ammonium acetate (17650-98-5 free base) |
cholecystokinin | GPCR/G Protein |
Ceruletide Ammonium acetate (FI-6934 Ammonium acetate) 是一种胆囊收缩素 (CCK) 受体激动剂。它是一种安全有效的胆囊动力剂和小肠和胰腺外分泌兴奋剂。 | |||
T68482 | CE-326597 | ||
CE-326597 is a potent and selective CCK1R agonist. The type 1 cholecystokinin receptor (CCK1R) has multiple physiologic roles relating to nutrient homeostasis,including mediation of postcibal satiety. The type 1 cholecystokinin (CCK) receptor (CCK1R) is a key mediator of postcibal satiety and a potential target for drugs that may be useful to prevent and/or treat obesity. | |||
T8761 |
[Leu15]-Gastrin I human
Amino Acid Sequence Glp-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Leu-Asp-Phe-NH2 |
Others | Others |
[Leu15]-Gastrin I human (Amino Acid Sequence Glp-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Leu-Asp-Phe-NH2) 基因编码人体内的蛋白质 [Leu15]-胃泌素 I。在人类染色体中,GAST 基因定位于 17q21.2。胃窦中的 G 细胞产生 [Leu15]-胃泌素 I 的前体前胃泌素。前胃泌素经过裂解和加工产生胃泌素,它对整个胃肠道上皮细胞具有营养作用。胃泌素对消化系统的生长至关重要,并刺激壁细胞产生胃酸。胃泌素通过称为胆囊收缩素(CCK) 或 CCK-B 受体 (CCK-BR) 的 G 蛋白偶联受体发挥其功能。胃泌素的释放受到食物的刺激,尤其是蛋白质饮食,并受到非常低的 pH 值的抑制。萎缩性胃炎、幽门螺杆菌感染和长期服用质子泵抑制剂感染可能导致胃泌素过度表达。胃腺癌显示高水平的胃泌素。 |