Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tarazepide is a potent and specific antagonist of CCK-A receptor.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
25 mg | ¥ 15,000 | 8-10周 | ||
50 mg | ¥ 19,800 | 8-10周 | ||
100 mg | ¥ 25,500 | 8-10周 |
产品描述 | Tarazepide is a potent and specific antagonist of CCK-A receptor. |
体内活性 | duodenal electric activity decreased by Tarazepide, reduces interdigestive pancreatic secretion, especially protein; reduces cephalic and early postprandial (milk) induced secretion of bicarbonate and protein.Pancreatic protein secretion to intravenous CCK-8 was little affected by atropine, but was significantly reduced by Tarazepide±Atropine; in contrast, protein secretion to intraduodenal CCK-8 was abolished by Tarazepide or atropine[1]. Leptin is administered to the animals at doses of 0.1, 1.0 or 10.0 μg/kg i.d. Tarazepide (2.5 mg/kg, i.d.), a CCK(1) receptor antagonist, is given to the rats prior to the application of leptin. CCK plasma level is measured by radioimmunoassay (RIA) following administration of leptin to the rats. Intraduodenal administration of leptin (1.0 or 10.0 microg/kg) to the fasted rats significantly and dose-dependently increases pancreatic protein and amylase outputs. Capsaicin inactivates sensory nerves or pretreatment with taracidide completely eliminates pancreatic secretory response to leptin[2]. |
分子量 | 448.52 |
分子式 | C28H24N4O2 |
CAS No. | 141374-81-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Tarazepide 141374-81-4 Others Inhibitor inhibitor inhibit