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抑制剂 & 化合物

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T24728	Rosaprostol C 83
	Rosaprostol is an agent of the anti-ulcer drug.
T6277	Doramapimod BIRB 796,达马莫德,度马莫德	Raf; p38 MAPK; Autophagy	Autophagy; MAPK
	Doramapimod (BIRB 796) 是一种具有口服活性的p38 MAPK 抑制剂，Kd 值为0.1nM。它也抑制B-Raf 和 Abl，IC50分别为 83 nM 和 14.6 μM。
T34278	Redaporfin F 2BMet,F2BMet,F-2BMet,LUZ11,LUZ 11,LUZ-11
	Redaporfin, also known as F-2BMet or LUZ-11, is a photosensitizer for Photodynamic Therapy (PDT) of cancer. Redaporfin showed a high efficacy in the treatment of male BALB/c mice with subcutaneously implanted colon (CT26) tumours. Vascular-PDT with 1.5 mg
T79572	MAPK-IN-2	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	MAPK-IN-2 (化合物3h)是一种携带抗肿瘤活性的高效MAPK抑制剂。它在多个癌细胞系中有效抑制了细胞增殖，并对MAPK途径表现出强大的抑制效果（EGFRWT IC50=281 nM, c-MET IC50=205 nM, B-RAFWT IC50=112 nM, CDK4/6 IC50=95和184 nM），对突变型EGFR和B-RAF亦展现出高效力（EGFRT790M IC50=69 nM, B-RAFV600E IC50=83 nM）。
T35463	(±)14(15)-EET (±)14,15-EET,(±)14,15-EpETrE,(±)14(15)-EET
	(±)14(15)-EET is a metabolite of arachidonic acid that is formed via epoxidation of arachidonic acid by cytochrome P450.[1],[2] It prevents increases in leukotriene B4, ICAM-1, and chemokine (C-C motif) ligand 1 (CCL2) induced by oxidized LDL in primary rat pulmonary artery endothelial cells (RPAECs) when used at a concentration of 1 μM.[3] (±)14(15)-EET induces dilation of preconstricted isolated canine coronary arterioles (EC50 = 0.2 pM).[4] It reduces myocardial infarct size as a percentage o...

化合物

Synonym: BIRB 796,达马莫德,度马莫德

Target: Raf, p38 MAPK, Autophagy

Redaporfin

Cat.No: T34278

Synonym: F 2BMet,F2BMet,F-2BMet,LUZ11,LUZ 11,LUZ-11

Synonym: (±)14,15-EET,(±)14,15-EpETrE,(±)14(15)-EET

Target:

Cat. No.	Product Name	Target	Signaling Pathways
TN1756	Hypocrellin C	Others	Others
	Hypocrellin C是一种天然产物，其产品编号为 TN1756，CAS号为 149457-83-0。Hypocrellin C可用作对照参考。