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Search Results for " bimatoprost "

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抑制剂 & 化合物

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天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T2538	Bimatoprost AGN 192024,比马前列素	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	Bimatoprost (AGN 192024) 是一种氯前列醇衍生的酰胺，用作治疗开角型青光眼和高眼压症的抗高血压药。
T10544	Bimatoprost D5 AGN 192024 D5	Others	Others
	Bimatoprost (AGN 192024) D5 is a deuterium-labeled Bimatoprost. Bimatoprost is a topical hypotensive agent frequently used for treating glaucoma and ocular hypertension.
T36908	Bimatoprost grenod 15-(6-nitroxyhexanoyl)-17-phenyl trinor Prostaglandin F2α
	Bimatoprost grenod(15-(6-nitroxyhexanoyl)-17-phenyl trinor PGF2α) is a nitric oxide-donating derivative of 17-phenyl trinor PGF2α.1It increases cGMP levels in rabbit aqueous humor and iris ciliary body when topically administered at a concentration of 0.042%. Topical administration of 15-(6-nitroxylhexanoyl)-17-phenyl trinor PGF2α(0.14%) reduces intraocular hypertension (IOP) in a rabbit model of hypertonic saline-induced transient ocular pressure. It also reduces IOP in a cynomolgus monkey mode...
T30452	Bimatoprost isopropyl ester 17-phenyl trinor PGF2α-iPr,17-phenyl trinor PGF2α isopropyl ester
	Bimatoprost isopropyl ester is an F-series prostaglandin analog, which has been approved as a hypotensive drug.
T37945	Bimatoprost methyl ester 17-phenyl trinor Prostaglandin F2α methyl ester
	Prostaglandin F2α (PGF2α) drives luteolysis and smooth muscle contraction by activating the FP receptor. Bimatoprost methyl ester is a lipophilic analog of 17-phenyl trinor PGF2α, a potent agonist for the FP receptor. 17-phenyl trinor PGF2α binds the FP receptor on ovine luteal cells with a relative potency of 756% compared to that of PGF2α. Esters of PGs serve as prodrugs, as they are efficiently hydrolyzed in certain tissues to generate the bioactive free acid.
T37939	N-Desethyl Bimatoprost 17-phenyl trinor Prostaglandin F2α amide
	N-Desethyl Bimatoprost (17-phenyl trinor PGF2α amide) is an F-series PG analog in which the C-1 carboxyl group has been modified to an unsubstituted amide. PG esters have been shown to have ocular hypotensive activity. PG N-ethyl amides were recently introduced as alternative PG hypotensive prodrugs. Although it has been claimed that PG amides are not converted to the free acids in vivo, studies have shown that bovine and human corneal tissue converts the amides of various PGs to the free acids ...
T37724	Lumula
	There are currently four prostaglandin (PG) derivatives which have been approved for human clinical use for the treatment of glaucoma. The names of the PGs and the concentrations of the approved doses are: travoprost (40 μg/ml), latanoprost (50 μg/ml), bimatoprost (300 μg/ml), and unoprostone (1,500 μg/ml). All of these compounds are modified at C-1 in order to act as lipophilic prodrugs in the eye. All have also been postulated to function via activation of the prostanoid FP receptor. Unoprosto...
T37944	17-phenyl trinor Prostaglandin F2α methyl amide 17-phenyl trinor Prostaglandin F2α methyl amide
	17-phenyl trinor Prostaglandin F2α (17-phenyl trinor PGF2α) is a metabolically stable analog of PGF2α and is a potent agonist for the FP receptor, binding with a relative potency of 756% compared to that of PGF2α. The ethyl amide of 17-phenyl trinor PGF2α bimatoprost has been approved for use as an ocular hypotensive drug. 17-phenyl trinor PGF2α methyl amide is an analog of bimatoprost. Its biological and toxicological properties have not been evaluated.
T37943	17-phenyl trinor Prostaglandin F2α isopropyl ester 17-phenyl trinor Prostaglandin F2α isopropyl ester
	17-phenyl trinor PGF2α N-ethyl amide is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug, sold under the Allergan trade name Bimatoprost. The N-ethyl amide prostaglandin prodrugs are converted to the active free acid more slowly than the analogous prostaglandin ester prodrugs such as latanoprost. This product is the isopropyl ester of the free acid prostaglandin which corresponds to Bimatoprost. The free acid, 17-phenyl trinor PGF2α, is a potent FP r...
T37934	15-keto-17-phenyl trinor Prostaglandin F2α 15-keto-17-phenyl trinor Prostaglandin F2α
	Bimatoprost is an F-series prostaglandin (PG) analog which has been approved for use as an ocular hypotensive drug. Oxidation of the C-15 hydroxyl group and amide hydrolysis of Bimatoprost produces 15-keto-17-phenyl trinor PGF2α. 15-keto-17-phenyl trinor PGF2α is a potential metabolite of bimatoprost when administered to animals. 15-keto PG analogs are potential minor impurities in commercial preparations of their corresponding bulk drug compounds. Although much less potent that the parent compo...
T35944	15-keto-17-phenyl trinor Prostaglandin F2α ethyl amide 15-keto-17-phenyl trinor Prostaglandin F2α ethyl amide
	Bimatoprost is the Allergan trade name for 17-phenyl trinor prostaglandin F2α ethyl amide (17-phenyl trinor PGF2α ethyl amide), an F-series PG analog which has been approved for use as an ocular hypotensive drug. Oxidation of the C-15 hydroxyl group produces 15-keto-17-phenyl trinor PGF2α ethyl amide. 15-keto-17-phenyl trinor PGF2α ethyl amide is a potential metabolite of 17-phenyl trinor PGF2α ethyl amide when 17-phenyl trinor PGF2α ethyl amide is administered to intact animals. No pharmacologi...
T38114	AL 8810 ethyl amide
	AL 8810 is an 11β-fluoro analog of prostaglandin F2α (PGF2α) which acts as a potent and selective antagonist at the FP receptor. AL 8810 ethyl amide is an analog of AL 8810 in which the C-1 carboxyl group has been modified to an N-ethyl amide. This modification is analogous to the PG N-ethyl amides, as typified by Bimatoprost, that have been introduced as alternative PG ocular hypotensive prodrugs. In contrast to AL 8810 which contracted the cat iris, AL 8810 ethyl amide showed no contraction ac...

化合物

Cat.No: T2538

Synonym: AGN 192024,比马前列素

Target: Prostaglandin Receptor

Bimatoprost D5

Cat.No: T10544

Synonym: AGN 192024 D5

Target: Others

Bimatoprost grenod

Cat.No: T36908

Synonym: 15-(6-nitroxyhexanoyl)-17-phenyl trinor Prostaglandin F2α

Bimatoprost isopropyl ester

Cat.No: T30452

Synonym: 17-phenyl trinor PGF2α-iPr,17-phenyl trinor PGF2α isopropyl ester

Bimatoprost methyl ester

Cat.No: T37945

Synonym: 17-phenyl trinor Prostaglandin F2α methyl ester

N-Desethyl Bimatoprost

Cat.No: T37939

Synonym: 17-phenyl trinor Prostaglandin F2α amide

Cat.No: T37724

17-phenyl trinor Prostaglandin F2α methyl amide

Cat.No: T37944

Synonym: 17-phenyl trinor Prostaglandin F2α methyl amide

17-phenyl trinor Prostaglandin F2α isopropyl ester

Cat.No: T37943

Synonym: 17-phenyl trinor Prostaglandin F2α isopropyl ester

15-keto-17-phenyl trinor Prostaglandin F2α

Cat.No: T37934

Synonym: 15-keto-17-phenyl trinor Prostaglandin F2α

15-keto-17-phenyl trinor Prostaglandin F2α ethyl amide

Cat.No: T35944

Synonym: 15-keto-17-phenyl trinor Prostaglandin F2α ethyl amide

AL 8810 ethyl amide

Cat.No: T38114

Cat. No.	Product Name	Target	Signaling Pathways
T20939	Bimatoprost acid 17-phenyl trinor PGF2α,17-phenyl trinor Prostaglandin F2α	GPR	Endocrinology/Hormones; GPCR/G Protein
	Bimatoprost acid (17-phenyl trinor PGF2α) 是一种代谢稳定的 PGF2α 类似物，对 FP 受体具有潜在的拮抗活性。与 PGF2α 相比，它与绵羊黄体细胞上的 FP 受体结合的相对效力为 756%。

天然产物

Bimatoprost acid

Cat.No: T20939

Synonym: 17-phenyl trinor PGF2α,17-phenyl trinor Prostaglandin F2α

Target: GPR

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