Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T20765 |
Atorvastatin
阿托伐他汀,阿伐他汀 |
HMG-CoA Reductase; Autophagy | Autophagy; Metabolism |
Atorvastatin 是一种具有口服活性的 HMG-CoA 还原酶抑制剂,通过激活肝细胞色素p450加快代谢,具有有效降低血脂的能力。Atorvastatin 以 IC50 值分别为 0.39 μM 和 2.39 μM 来抑制人 SV-SMC 细胞的增殖和侵袭。Atorvastatin 与氯吡格雷同时服用两种可能会导致患者血栓事件增加。 | |||
T3116 |
Atorvastatin hemicalcium salt
Lipitor,Atorvastatin hemicalcium,Atorvastatin Calcium,CI-981,阿托伐他汀钙,Sortis |
Ferroptosis; HMG-CoA Reductase; Autophagy | Apoptosis; Autophagy; Metabolism |
Atorvastatin hemicalcium salt (Atorvastatin Calcium) 是一种口服有效的 HMG-CoA 还原酶抑制剂 ,可用作降低胆固醇的药物。它抑制人 SV-SMC 增殖和侵袭,IC50分别为 0.39 μM 和 2.39 μM。 | |||
T14342 |
Atorvastatin lactone
|
HMG-CoA Reductase | Metabolism |
Atorvastatin lactone 是一种 Atorvastatin 的前药。其中 Atorvastatin 是口服具有活力的 3- 羟基 -3- 甲基戊二酰辅酶 A 还原酶抑制剂。 | |||
T20887 |
Atorvastatin Sodium
Lipitor |
LDL; Aquaporin; HMG-CoA Reductase | Membrane transporter/Ion channel; Metabolism |
Atorvastatin Sodium (Lipitor) 是一种HMG-CoA 还原酶的竞争性抑制剂,增加肝细胞上低密度脂蛋白(LDL)受体的表达。Atorvastatin sodium 处理抑制水汽蛋白4来减轻缺血性脑水肿。 | |||
TQ0045 |
2-Hydroxy atorvastatin calcium salt
|
Drug Metabolite | Metabolism |
2-Hydroxy atorvastatin calcium salt 是 Atorvastatin 钙盐的羟基代谢物,Atorvastatin 是一种有效的 HMG-CoA 还原酶抑制剂 (IC50 = 8 nM)。 | |||
T21363 |
Atorvastatin calcium trihydrate
CI-981,atorvastatin, calcium salt,CI981,Atorvastatin,CI 981 |
||
Atorvastatin is used to inhibits HMG-CoA reductase for lowering blood cholesterol and for prevention of events associated with cardiovascular disease. | |||
T21080 |
(3S,5S)-Atorvastatin
ent-Atorvastatin,3S,5S-Atorvastatin,(3S,5S)-阿托伐他汀 |
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ent-Atorvastatin is a selective and competitive inhibitor of HMGCR (HMG-CoA reductase). | |||
T69006 |
Atorvastatin lysine
|
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Atorvastatin lysine is a selective and competitive HMGCR (HMG-CoA reductase) inhibitor. | |||
T10399 |
Atorvastatin 3-Deoxyhept-2E-Enoic Acid
(2E)-2,3-Dehydroxy Atorvastatin |
Others | Others |
Atorvastatin 3-Deoxyhept-2E-Enoic Acid is an impurity of Atorvastatin. Atorvastatin is an HMG-CoA reductase inhibitor and has the ability to effectively decrease blood lipids. | |||
T71560 | Atorvastatin magnesium trihydrate | ||
Atorvastatin magnesium trihydrate is used primarily for lowering blood cholesterol and for prevention of events associated with cardiovascular disease. Like all statins, atorvastatin works by inhibiting HMG-CoA reductase, an enzyme found in liver tissue that plays a key role in production of cholesterol in the body.Atorvastatin is also used for the treatment of dyslipidemia. | |||
T15127 |
Difluoro atorvastatin
Fluoroatorvastatin |
Others | Others |
Difluoro atorvastatin is an Atorvastatin impurity. Atorvastatin is an orally active HMG-CoA reductase inhibitor and it has the ability to effectively decrease blood lipids. Atorvastatin inhibits human SV-SMC proliferation and invasion (IC50s: 0.39 μM and | |||
T13562 |
Atorvastatin methyl ester
|
Others | Others |
Atorvastatin methyl ester is a derivative of Atorvastatin. It inhibits the 9-cis-RA-induced Gal4 reporter activity more strongly than Atorvastatin. | |||
T38249 |
2-Hydroxy atorvastatin lactone
|
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2-Hydroxy atorvastatin lactone, a metabolite of Atorvastatin, is an orally active HMG-CoA reductase inhibitor that efficiently reduces blood lipids [1][2]. | |||
T10401 |
Atorvastatin acetonide
|
Others | Others |
Atorvastatin acetonide is an impurity of Atorvastatin. Atorvastatin is an HMG-CoA reductase inhibitor and has the ability to effectively decrease blood lipids. | |||
T15099 |
Desfluoro-atorvastatin
|
Others | Others |
Desfluoro-atorvastatin is an Atorvastatin impurity. Atorvastatin is an orally active inhibitor of HMG-CoA reductase. It has the ability to effectively decrease blood lipids. | |||
T35724 |
4-hydroxy Atorvastatin (calcium salt)
|
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4-hydroxy Atorvastatin is a metabolite of atorvastatin , an HMG-CoA reductase inhibitor present in formulations that have been used to treat hypercholesterolemia and certain dyslipidemias. Atorvastatin is metabolized by the cytochrome P450 (CYP) isoform CYP3A4 to form 4-hydroxy atorvastatin. | |||
T10127 | (3R,5S)-Atorvastatin sodium | Others | Others |
(3R,5S)-Atorvastatin sodium is an impurity of Atorvastatin. Atorvastatin is an HMG-CoA reductase inhibitor and has the ability to effectively decrease blood lipids. | |||
T10403 |
Atorvastatin ethyl ester
|
Others | Others |
Atorvastatin ethyl ester, a derivative of Atorvastatin, exhibits potent inhibition of 9-cis-RA-induced Gal4 reporter activity. | |||
T10120 |
3-Oxo Atorvastatin
|
Others | Others |
3-Oxo Atorvastatin is an impurity of Atorvastatin. Atorvastatin is an HMG-CoA reductase inhibitor and has the ability to effectively decrease blood lipids. | |||
T30202 |
Atorvastatin, (3S,5R)-
AT10 Trans |
||
Atorvastatin, (3S,5R)- is an Atorvastatin impurity. | |||
T12283 |
O-Methyl Atorvastatin hemicalcium
|
Others | Others |
O-Methyl Atorvastatin is an impurity of Atorvastatin that is an orally active inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, has the ability to effectively decrease blood lipids. | |||
T10402 |
Atorvastatin Epoxy Tetrahydrofuran Impurity
|
Others | Others |
Atorvastatin Epoxy Tetrahydrofuran Impurity is an impurity isolated oxidative degradation products of Atorvastatin. Atorvastatin is an orally active HMG-CoA reductase inhibitor. | |||
T10400 |
Atorvastatin acetonide tert-butyl ester
|
Others | Others |
Atorvastatin acetonide tert-butyl ester is a useful pharmaceutical intermediate in the preparation of Atorvastatin salts. Atorvastatin is an HMG-CoA reductase inhibitor. | |||
T72101 |
Atorvastatin hemicalcium trihydrate
阿托伐他汀半钙三水合物,阿托他伐汀半钙三水合物 |
||
Atorvastatin hemicalcium trihydrate 是一种具有口服活性的 HMG-CoA 还原酶抑制剂,具有有效降低血脂的能力。Atorvastatin hemicalcium trihydrate 以 IC50值分别为 0.39 μM 和 2.39 μM 来抑制人 SV-SMC 细胞的增殖和侵袭。 | |||
T68467 | Atorvastatin magnesium | ||
Atorvastatin magnesium is an HMG-CoA inhibitor. | |||
T71492 |
Atorvastatin strontium
|
||
Atorvastatin strontium is used primarily for lowering blood cholesterol and for prevention of events associated with cardiovascular disease. Like all statins, atorvastatin works by inhibiting HMG-CoA reductase, an enzyme found in liver tissue that plays a key role in production of cholesterol in the body.Atorvastatin is also used for the treatment of dyslipidemia. | |||
T11954 | MB-07344 | Others | Others |
MB-07344 has additive cholesterol lowering activity in combination with Atorvastatin in rabbits, dogs and monkeys. MB-07344 is a potent thyroid hormone receptor (TR)-β agonist with a Ki of 2.17 nM. | |||
T11954L | MB-07344 sodium | Others | Others |
MB-07344 sodium has additive cholesterol lowering activity in combination with Atorvastatin in rabbits, dogs and monkeys. MB-07344 sodium is a potent thyroid hormone receptor (TR)-β agonist with a Ki of 2.17 nM. | |||
T83777 |
LAU-0901
|
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LAU-0901是一种血小板活化因子(PAF)受体拮抗剂。在体内,LAU-0901(30、60及90 mg/kg)通过减少梗塞体积和改善大鼠由中脑动脉阻塞(MCAO)引起的脑缺血模型中的神经功能来发挥作用。它还能减少同一模型中的小胶质细胞浸润,并增加星形胶质细胞和神经元的存活率。单独使用LAU-0901(30 mg/kg)或与阿托伐他汀联合使用,能减少U87MG胶质母细胞瘤小鼠原位肿瘤模型中的肿瘤生长。 | |||
T35799 |
MBX-8025 (sodium salt)
|
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MBX-8025 is an agonist of peroxisome proliferator-activated receptor δ (PPARδ).1 It is greater than 750- and 2,500-fold selective for PPARδ over PPARα and PPARγ. MBX-8025 (10 mg/kg per day for eight weeks) reduces increases in fasting blood glucose and serum insulin levels, and decreases insulin resistance in Alms1 mutant (foz/foz) mice fed an atherogenic diet as a model of diet-induced obesity, type 2 diabetes, and non-alcoholic steatohepatitis (NASH).2 It also decreases serum alanine transamin... |