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Search Results for " anaphylatoxin "

Targets Recommended: Complement System

抑制剂 & 化合物

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T80131	C5a Anaphylatoxin (human)	Complement System	Immunology/Inflammation
	C5a Anaphylatoxin (human)为促炎多肽及白细胞化学引诱剂，主要应用于炎症与免疫领域研究，例如过敏性哮喘。
T17250	W-54011	ROS; Complement System	Immunology/Inflammation
	W-54011 是口服有效的非肽 C5a 受体拮抗剂，抑制125I 标记的 C5a 与人嗜中性白细胞的结合，Ki 为 2.2 nM。它还抑制C5a 诱导的人嗜中性粒细胞的细胞内 Ca2+动员，趋化性和ROS 的生成，IC50分别为 3.1 nM、2.7 nM 和1.6 nM。
TP1193	C3a (70-77) TFA (63555-63-5 free base) C3a (70-77) TFA,Complement 3a (70-77) (TFA)
	C3a (70-77) TFA (Complement 3a (70-77) TFA) is a COOH-terminal fragment of the C3a anaphylatoxin peptide.
T82797	C5aR1 antagonist peptide
	C5aR1 antagonist peptide 是一种源自C5a (趋化因子补体片段5过敏毒素) C末端的生物活性线性肽。它能在人和大鼠的C5a受体上阻断C5a的结合，对于细胞免疫反应的触发起着关键作用。C5a的过度表达与多种免疫炎性疾病如关节炎、阿尔茨海默病、囊性纤维化和系统性红斑狼疮等有着密切关联。
T80265	C5a Receptor agonist, mouse, human	Complement System	Immunology/Inflammation
	C5a Receptor agonist, mouse, human 是一种源自血浆蛋白C5a C末端的生物活性肽，充当C5a受体激动剂。此化合物在调控细胞炎症反应中起关键作用，包括促进趋化性、白细胞脱颗粒、增加血管通透性以及刺激细胞因子的产生。化合物的结构中，第5位环己基丙氨酸对激动剂功能至关重要，同时末端的Arg采用d-异构体形式。

化合物

C5a Anaphylatoxin (human)

Cat.No: T80131

Synonym:

Target: Complement System

W-54011

Cat.No: T17250

Synonym:

Target: ROS, Complement System

C3a (70-77) TFA (63555-63-5 free base)

Cat.No: TP1193

Synonym: C3a (70-77) TFA,Complement 3a (70-77) (TFA)

Target:

C5aR1 antagonist peptide

Cat.No: T82797

Synonym:

Target:

C5a Receptor agonist, mouse, human

Cat.No: T80265

Synonym:

Target: Complement System

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-00416	Complement C3a Protein, Mouse, Recombinant C3a,Complement Component C3a,Anaphylatoxin	Mouse	E. coli
	Complement C3a Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 9 KDa and the accession number is P01027.
TMPH-03107	Complement C5a Protein, Pig, Recombinant (His) Complement C5a anaphylatoxin,C5	Sus scrofa (Pig)	P. pastoris (Yeast)
	Derived from proteolytic degradation of complement C5, C5a anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes. C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation....
TMPJ-00417	Complement C3a Protein, Human, Recombinant Anaphylatoxin,C3a,Complement Component C3a	Human	E. coli
	Complement C3a Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 13 KDa and the accession number is P01024.
TMPH-01022	C5AR1 Protein-VLP, Human, Recombinant (His) C5a anaphylatoxin chemotactic receptor 1,CD88,C5a <...	Human	HEK293 Cells
	Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events. Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production. C5AR1 Protein-VLP, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-...
TMPH-01023	C5AR1 Protein, Human, Recombinant (Cell-Free, His) C5a anaphylatoxin chemotactic receptor 1,C5R1,C5a-R...	Human	E. coli
	Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events. Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production. C5AR1 Protein, Human, Recombinant (Cell-Free, His) is expressed in E. coli expression syst...
TMPH-03529	Chemotaxis inhibitory Protein, S. aureus (strain MRSA252), Recombinant (His) CHIPS,Chemotaxis inhibitory protein,chp	Staphylococcus aureus	P. pastoris (Yeast)
	Involved in countering the first line of host defense mechanisms. Specifically inhibits the response of human neutrophils and monocytes to complement anaphylatoxin C5a and formylated peptides, like N-formyl-methionyl-leucyl-phenylalanine (fMLP). Acts by binding directly to the C5a receptor (C5aR) and formylated peptide receptor (FPR), thereby blocking the C5a- and fMLP-induced calcium responses. Prevents phagocytosis of the bacterium. Chemotaxis inhibitory Protein, S. aureus (strain MRSA252), Re...
TMPH-03528	Chemotaxis inhibitory Protein, S. aureus (strain NCTC 8325/PS47), Recombinant (His & Myc) chp,Chemotaxis inhibitory protein,CHIPS	Staphylococcus aureus	E. coli
	Involved in countering the first line of host defense mechanisms. Specifically inhibits the response of human neutrophils and monocytes to complement anaphylatoxin C5a and formylated peptides, like N-formyl-methionyl-leucyl-phenylalanine (fMLP). Acts by binding directly to the C5a receptor (C5aR) and formylated peptide receptor (FPR), thereby blocking the C5a- and fMLP-induced calcium responses. Prevents phagocytosis of the bacterium. Chemotaxis inhibitory Protein, S. aureus (strain NCTC 8325/PS...