Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T6837 |
Flavopiridol
L868275,Alvocidib,夫拉平度,NSC 649890 HCl,HMR-1275 |
Apoptosis; HIV Protease; CDK; Autophagy | Apoptosis; Autophagy; Cell Cycle/Checkpoint; Microbiology/Virology; Proteases/Proteasome |
Flavopiridol (Alvocidib) 是一种广谱CDK 竞争型抑制剂, 抑制 CDK1,CDK2,CDK4的IC50分别为30,170,100 nM。 | |||
T2615 |
Flavopiridol hydrochloride
Alvocidib Hydrochloride,NSC 649890,MDL 107826A,HL 275,FLAVOPIRIDOL HCL,NSC 649890 HCl |
HIV Protease; CDK; Autophagy | Autophagy; Cell Cycle/Checkpoint; Microbiology/Virology; Proteases/Proteasome |
Flavopiridol hydrochloride (MDL 107826A) 是一种CDK 的广谱抑制剂,与 ATP 竞争性地抑制 CDK1,CDK2 和 CDK4 的活性,IC50值分别为 30, 170, 100 nM。 | |||
T69965 | TP1287 | ||
TP-1287 is an oral phosphate prodrug of the CDK9 inhibitor, alvocidib. | |||
T70897 | Zotiraciclib HCl | ||
Zotiraciclib, also known as TG02 and SB1317, is a novel small molecule potent CDK/JAK2/FLT3 inhibitor. Zotiraciclib may be useful for the treatment of cancer that crosses the blood brain barrier and acts by depleting Myc through the inhibition of cyclin-dependent kinase 9 (CDK9). It is one of a number of CDK inhibitors under investigation; others targeting CDK9 for the treatment of acute myeloid leukemia include alvocidib and atuveciclib. Myc overexpression is a known factor in many cancers, w... |