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Search Results for " alpha-toxin "

Targets Recommended: Potassium Channel

8

抑制剂 & 化合物

18

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T80530	Spinoxin SPX,α-KTx6.13,Potassium channel toxin alpha-KTx 6.13	Potassium Channel	Membrane transporter/Ion channel
	Spinoxin是一种从Heterometrus spinifer蝎子毒液中提取的神经毒素，由34个氨基酸残基组成，通过4个二硫桥交联。它能有效抑制Kv1.3钾通道（IC50= 63 nM），是研发诊断及治疗自身免疫性疾病和癌症策略时的潜在分子靶点。
T22297	Clindamycin hydrochloride monohydrate Clindamycin alcoholate	Antibiotic	Microbiology/Virology
	Clindamycin hydrochloride monohydrate（Clindamycin alcoholate）是一种口服蛋白质合成抑制剂，具有在金黄色葡萄球菌中以亚抑制浓度(sub-MICs)抑制毒力因子表达的能力。其抗性来源于50S核糖体亚基（23S rRNA）的抗生素结合位点通过酶促甲基化。此外，Clindamycin hydrochloride monohydrate能显著减少杀白细胞毒素（PVL）、毒性休克-葡萄球菌毒素（TSST-1）或α-溶血素（Hla）的产生。
T13540	alpha-Amanitin α-Amanitin,α-Amatoxin	Others	Others
	alpha-Amanitin is the principal toxin of poisonous mushrooms, exerting its toxic function by inhibiting RNA-polymerase II.
T82949	Atidortoxumab
	Atidortoxumab是针对Staphylococcus aureus alpha毒素的人类IgG1κ单克隆抗体。
T81832	MC-VC-PABC-C6-alpha-Amanitin
	MC-VC-PABC-C6-alpha-Amanitin是一款针对HER2受体的ADC，包含致癌毒素alpha-Amanitin及单克隆抗体MC-VC-PABC-C6。alpha-Amanitin主要抑制RNA聚合酶IIα。该化合物专一性地靶向HER2阳性肿瘤细胞，主要应用于乳腺癌与胃癌的研究领域。
T80482	α-Conotoxin EIIB Alpha-conotoxin EIIB
	α-Conotoxin EIIB（Alpha-conotoxin EIIB）是从芋螺（Conus ermineus）毒液中提取的一种肽类毒素，具有与nAChR结合的能力（Ki=2.2 nM）。该毒素肽在神经性疾病（包括精神分裂症、药物成瘾、阿尔茨海默病以及帕金森病）的研究中有应用。
T76973	Tosatoxumab
	Tosatoxumab (AR-301; KBSA301) 为一种人源化免疫球蛋白G1类单克隆抗体，专一性地中和金黄色葡萄球菌α毒素(α-溶血素; Hla)，通过与该毒素N末端表位结合，防止其功能性毒素孔的寡聚化。此抗体对于金黄色葡萄球菌引起的肺炎，作为传统抗生素疗法的辅助，展现出被动免疫治疗的潜力。
T80034	Margatoxin TFA	Potassium Channel	Membrane transporter/Ion channel
	Margatoxin TFA为一种α-KTx蝎毒素，具有对Kv1.3通道高度亲和性的抑制作用，Kd值为11.7 pM。该化合物还能够抑制Kv1.2和Kv1.1通道，其Kd分别为6.4 pM和4.2 nM。Margatoxin TFA是一种含39个氨基酸的肽类分子，源自Centruroides margaritatus的蝎毒，常用于离子通道的科学研究。

化合物

Cat.No: T80530

Synonym: SPX,α-KTx6.13,Potassium channel toxin alpha-KTx 6.13

Target: Potassium Channel

Clindamycin hydrochloride monohydrate

Cat.No: T22297

Synonym: Clindamycin alcoholate

Target: Antibiotic

alpha-Amanitin

Cat.No: T13540

Synonym: α-Amanitin,α-Amatoxin

Target: Others

Cat.No: T82949

MC-VC-PABC-C6-alpha-Amanitin

Cat.No: T81832

α-Conotoxin EIIB

Cat.No: T80482

Synonym: Alpha-conotoxin EIIB

Cat.No: T76973

Cat.No: T80034

Target: Potassium Channel

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-03523	Alpha-hemolysin Protein, S. aureus, Recombinant (His & SUMO) Alpha-HL,Alpha-toxin	Staphylococcus aureus	E. coli
	Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Inhibits host neutrophil chemotaxis to the lesion region (Probable). Heptamer oligomerization and pore formation is required for lytic activity.
TMPH-03522	Alpha-hemolysin Protein, S. aureus, Recombinant (His) Alpha-toxin,Alpha-HL	Staphylococcus aureus	P. pastoris (Yeast)
	Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Inhibits host neutrophil chemotaxis to the lesion region (Probable). Heptamer oligomerization and pore formation is required for lytic activity.
TMPH-00054	AaH II Protein, Androctonus australis, Recombinant (His & SUMO) Toxin II,Neurotoxin II,AaHII,Alpha	Androctonus australis	E. coli
	AaH II Protein, Androctonus australis, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 23.3 kDa and the accession number is P01484.
TMPH-00837	BjaIT Protein, Hottentotta judaicus, Recombinant (His & Myc) Alpha-insect toxin BjaIT,Bj-alpha...	Hottentotta judaicus	E. coli
	Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. This toxin is active against insects (para/tipE). BjaIT Protein, Hottentotta judaicus, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 14.4 kDa and the accession number is Q56TT9.
TMPH-00055	Alpha-toxin Amm8 Protein, Androctonus mauritanicus, Recombinant (His & Myc) AmmVIII,Neurotoxin 8,Alpha-anatoxin	Androctonus mauritanicus	Baculovirus Insect Cells
	Alpha-toxin Amm8 Protein, Androctonus mauritanicus, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 11.3 kDa and the accession number is Q7YXD3.
TMPH-03625	Alpha-mammal toxin Ts2 Protein, Tityus serrulatus, Recombinant (His & Myc) Tityustoxin II,TsTX III-8,Toxin II,Tst2,	Tityus serrulatus	Baculovirus Insect Cells
	Alpha-mammal toxin Ts2 Protein, Tityus serrulatus, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 10.9 kDa and the accession number is P68410.
TMPK-01052	GFRAL/GFR alpha-like Protein, Mouse, Recombinant (His & Avi) GFRAL/GFR α-like Protein,GFR α-like,GRAL,C6orf144,GFR al...	Mouse	HEK293 Cells
	GFR alpha -like (GDNF receptor-alpha-like) is a distant member of the GDNFR family of proteins. Mature human GFR alpha-like is a 376 amino acid (aa) type I transmembrane protein. It contains a 333 aa extracellular domain, a 20 aa transmembrane domain and a 23 aa cytoplasmic domain.GFRAL is a brainstem-restricted receptor for GDF15 which regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses. GFRAL/GFR alpha-like Protein, Mouse, Recombinant (...
TMPK-01320	GFRAL/GFR alpha-like Protein, Cynomolgus, Recombinant (His & Avi), Biotinylated GRAL,GFRAL,C6orf144,GFRAL/GFR α-like Protein,GFR α-like,GFR ...	Cynomolgus	HEK293 Cells
	GFR alpha -like (GDNF receptor-alpha-like) is a distant member of the GDNFR family of proteins. Mature human GFR alpha-like is a 376 amino acid (aa) type I transmembrane protein. It contains a 333 aa extracellular domain, a 20 aa transmembrane domain and a 23 aa cytoplasmic domain.GFRAL is a brainstem-restricted receptor for GDF15 which regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses. GFRAL/GFR alpha-like Protein, Cynomolgus, Recombin...
TMPH-00430	VxXIIC Protein, Conus vexillum, Recombinant (His & Myc & SUMO)	Conus vexillum	E. coli
	Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin specifically blocks mammalian neuronal nAChR of the alpha-7/CHRNA7, alpha-3-beta-2/CHRNA3-CHRNB2 and alpha-4-beta-2/CHRNA4-CHRNB2 subtypes. VxXXA and VxXXB inhibit alpha-7/CHRNA7 and alpha-3-beta-2/CHRNA3-CHRNB2 nAChR more efficiently than VxXXC. VxXXB is the most effective at inhibiting alpha-4-beta-2/CHRNA4-CHRNB2 nAChR, followed by VxXXC and VxXXA. VxXII...
TMPK-01319	GFRAL/GFR alpha-like Protein, Cynomolgus, Recombinant (His & Avi) GFR alpha like,GRAL,GFRAL,C6orf144,GFRAL/GFR α-like...	Cynomolgus	HEK293 Cells
	GFR alpha -like (GDNF receptor-alpha-like) is a distant member of the GDNFR family of proteins. Mature human GFR alpha-like is a 376 amino acid (aa) type I transmembrane protein. It contains a 333 aa extracellular domain, a 20 aa transmembrane domain and a 23 aa cytoplasmic domain.GFRAL is a brainstem-restricted receptor for GDF15 which regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses. GFRAL/GFR alpha-like Protein, Cynomolgus, Recombin...
TMPK-01053	GFRAL/GFR alpha-like Protein, Mouse, Recombinant (His & Avi), Biotinylated GRAL,GFRAL/GFR α-like Protein,GFR alpha-like,GFR α-...	Mouse	HEK293 Cells
	GFR alpha -like (GDNF receptor-alpha-like) is a distant member of the GDNFR family of proteins. Mature human GFR alpha-like is a 376 amino acid (aa) type I transmembrane protein. It contains a 333 aa extracellular domain, a 20 aa transmembrane domain and a 23 aa cytoplasmic domain.GFRAL is a brainstem-restricted receptor for GDF15 which regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses. GFRAL/GFR alpha-like Protein, Mouse, Recombinant (...
TMPK-01059	GFRAL/GFR alpha-like Protein, Human, Recombinant (His & Avi), Biotinylated GFRAL/GFR α-like Protein,C6orf144,GFRAL,GFR alpha-l...	Human	HEK293 Cells
	GFR alpha -like (GDNF receptor-alpha-like) is a distant member of the GDNFR family of proteins. Mature human GFR alpha-like is a 376 amino acid (aa) type I transmembrane protein. It contains a 333 aa extracellular domain, a 20 aa transmembrane domain and a 23 aa cytoplasmic domain.GFRAL is a brainstem-restricted receptor for GDF15 which regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses. GFRAL/GFR alpha-like Protein, Human, Recombinant (...
TMPK-01058	GFRAL/GFR alpha-like Protein, Human, Recombinant (His & Avi) GFR alpha-like,GFRAL,C6orf144,GRAL,GFR α-like,GFRAL...	Human	HEK293 Cells
	GFR alpha -like (GDNF receptor-alpha-like) is a distant member of the GDNFR family of proteins. Mature human GFR alpha-like is a 376 amino acid (aa) type I transmembrane protein. It contains a 333 aa extracellular domain, a 20 aa transmembrane domain and a 23 aa cytoplasmic domain.GFRAL is a brainstem-restricted receptor for GDF15 which regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses. GFRAL/GFR alpha-like Protein, Human, Recombinant (...
TMPK-01060	GFRAL/GFR alpha-like Protein, Human, Recombinant (hFc) GFRAL,GRAL,C6orf144,GFR alpha-like,GFR α-like,GFRAL...	Human	HEK293 Cells
	GFR alpha -like (GDNF receptor-alpha-like) is a distant member of the GDNFR family of proteins. Mature human GFR alpha-like is a 376 amino acid (aa) type I transmembrane protein. It contains a 333 aa extracellular domain, a 20 aa transmembrane domain and a 23 aa cytoplasmic domain.GFRAL is a brainstem-restricted receptor for GDF15 which regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses. GFRAL/GFR alpha-like Protein, Human, Recombinant (...
TMPH-03652	Ustilago maydis P6 virus (UmV6) KP6 killer toxin (His)	UmV6	P. pastoris (Yeast)
	This protein is lethal to sensitive cells of the same or related species. The KP6 alpha subunit is known to recognize some cellular receptors before interaction of the complex with KP6 beta, precipitating cell death. Ustilago maydis P6 virus (UmV6) KP6 killer toxin (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 10.6 kDa and the accession number is P16948.
TMPH-02404	LqhaIT Protein, Leiurus hebraeus, Recombinant (His & SUMO)	Yellow scorpion	E. coli
	Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. The dissociation is voltage-dependent. This toxin is active on insects. It is also highly toxic to crustaceans and has a measurable but low toxicity to mice. LqhaIT Protein, Leiurus hebraeus, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 23.5 kDa and ...
TMPY-00583	ADPRH Protein, Human, Recombinant (His) ADP-ribosylarginine hydrolase,ARH1	Human	E. coli
	Cholera toxin (CT) produced by Vibrio cholerae causes the devastating diarrhea of cholera by catalyzing the ADP-ribosylation of the alpha subunit of the intestinal Gs protein (Gsalpha), leading to characteristic water and electrolyte losses. Mammalian cells contain ADP-ribosyltransferases similar to CT and an ADP-ribosyl(arginine)protein hydrolase (ADPRH), which cleaves the ADP-ribose-(arginine)protein bond, regenerating native protein and completing an ADP-ribosylation cycle. CT-catalyzed ADP-r...
TMPY-02246	HB-EGF Protein, Human, Recombinant DTSF,DTR,HEGFL,heparin-binding EGF-like growth factor,DTS	Human	Baculovirus Insect Cells
	Heparin-binding EGF-like growth factor (HBEGF), a member of the EGF family of growth factors, exerts its biological activity through activation of the EGFR and other ErbB receptors. Soluble mature HBEGF is proteolytically processed from a larger membrane-anchored precursor and is a potent mitogen and chemotactic factor for fibroblasts, smooth muscle cells but not endothelial cells. HBEGF activates two EGF receptor subtypes, HER1 and HER4, and binds to cell surface HSPG. The transmembrane form of...

重组蛋白

Alpha-hemolysin Protein, S. aureus, Recombinant (His & SUMO)

Cat.No: TMPH-03523

Species: Staphylococcus aureus

Expression System: E. coli

Alpha-hemolysin Protein, S. aureus, Recombinant (His)

Cat.No: TMPH-03522

Species: Staphylococcus aureus

Expression System: P. pastoris (Yeast)

AaH II Protein, Androctonus australis, Recombinant (His & SUMO)

Cat.No: TMPH-00054

Species: Androctonus australis

Expression System: E. coli

BjaIT Protein, Hottentotta judaicus, Recombinant (His & Myc)

Cat.No: TMPH-00837

Species: Hottentotta judaicus

Expression System: E. coli

Alpha-toxin Amm8 Protein, Androctonus mauritanicus, Recombinant (His & Myc)

Cat.No: TMPH-00055

Species: Androctonus mauritanicus

Expression System: Baculovirus Insect Cells

Alpha-mammal toxin Ts2 Protein, Tityus serrulatus, Recombinant (His & Myc)

Cat.No: TMPH-03625

Species: Tityus serrulatus

Expression System: Baculovirus Insect Cells

GFRAL/GFR alpha-like Protein, Mouse, Recombinant (His & Avi)

Cat.No: TMPK-01052

Species: Mouse

Expression System: HEK293 Cells

GFRAL/GFR alpha-like Protein, Cynomolgus, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-01320

Species: Cynomolgus

Expression System: HEK293 Cells

VxXIIC Protein, Conus vexillum, Recombinant (His & Myc & SUMO)

Cat.No: TMPH-00430

Species: Conus vexillum

Expression System: E. coli

GFRAL/GFR alpha-like Protein, Cynomolgus, Recombinant (His & Avi)

Cat.No: TMPK-01319

Species: Cynomolgus

Expression System: HEK293 Cells

GFRAL/GFR alpha-like Protein, Mouse, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-01053

Species: Mouse

Expression System: HEK293 Cells

GFRAL/GFR alpha-like Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-01059

Species: Human

Expression System: HEK293 Cells

GFRAL/GFR alpha-like Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-01058

Species: Human

Expression System: HEK293 Cells

GFRAL/GFR alpha-like Protein, Human, Recombinant (hFc)

Cat.No: TMPK-01060

Species: Human

Expression System: HEK293 Cells

Ustilago maydis P6 virus (UmV6) KP6 killer toxin (His)

Cat.No: TMPH-03652

Species: UmV6

Expression System: P. pastoris (Yeast)

LqhaIT Protein, Leiurus hebraeus, Recombinant (His & SUMO)

Cat.No: TMPH-02404

Species: Yellow scorpion

Expression System: E. coli

ADPRH Protein, Human, Recombinant (His)

Cat.No: TMPY-00583

Species: Human

Expression System: E. coli

HB-EGF Protein, Human, Recombinant

Cat.No: TMPY-02246

Species: Human

Expression System: Baculovirus Insect Cells

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