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Cat. No. Product Name Target Signaling Pathways
T35897 ASK120067

ASK120067 is a potent and orally active inhibitor of EGFRT790M (IC50:0.3 nM) with selectivity over EGFRWT (IC50:6.0 nM). ASK120067 is a third-generation EGFR-TKI for the research of non-small cell lung cancer (NSCLC)[1]. In the in vitro kinase assay ASK120067 potently inhibits the EGFR L858R/T790M and EGFR T790M resistant mutants with IC50 values of 0.3 nM and 0.5 nM, respectively, as well as the EGFRexon19del sensitizing mutant (IC50= 0.5 nM). The 50 of ASK120067 against wild-type EGFR (EGFRWT...
T22254 Alflutinib

AST2818,ASK120067

EGFR; P450 Angiogenesis; JAK/STAT signaling; Metabolism; Tyrosine Kinase/Adaptors
Alflutinib (ASK120067) 是 EGFR 抑制剂。 它对 T790M 的性耐药突变以及 EGFR 活性突变具有抑制作用。它对于癌症疾病,特别是非小细胞肺癌(NSC-LC)方面具有研究潜力。

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ASK120067
Cat.No: T35897
Synonym:
Target:
Alflutinib
Cat.No: T22254
Synonym: AST2818,ASK120067
Target: EGFR, P450
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