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Cat. No. Product Name Target Signaling Pathways
T13552 ARD-266

Others; PROTACs Others; PROTAC
ARD-266 is a highly potent and VHL E3 ligase-based androgen receptor (AR) PROTAC degrader. ARD-266 effectively induces the degradation of AR protein in AR-positive LNCaP, VCaP, and 22Rv1 prostate cancer cell lines (DC50s: 0.2-1 nM).
T10359 AR antagonist 1

Androgen Receptor; Ligand for E3 Ligase; Ligands for Target Protein for PROTAC Endocrinology/Hormones; PROTAC
AR antagonist 1 是 AR 拮抗剂,能够与 E3 连接酶配体结合,与 VHL 蛋白结合亲和力较弱,用于 PROTACARD-266 合成。
T18545 Pip-alkyne-Ph-COOCH3

Others Others
Pip-alkyne-Ph-COOCH3 is an alkyl-chain based PROTAC linker utilized for the synthesis of PROTAC ARD-266[1].
T18873 VHL Ligand-Linker Conjugates 17

Others Others
VHL Ligand-Linker Conjugates 17 are chemical compounds that consist of a VHL ligand specialized for the E3 ubiquitin ligase, as well as a PROTAC linker. These conjugates are utilized in the synthesis of various PROTACs, including the notable ARD-266. ARD-266 is an exceptionally effective androgen receptor (AR) PROTAC degrader[1].
T13958 VHL Ligand 8

Others Others
VHL Ligand 8 是一种 von Hippel-Lindau (VHL) 蛋白配体,可用于合成 ARD-266ARD-266 是一种基于 VHL E3 连接酶的高效雄激素受体 (AR) PROTAC 降解剂。ARD-266 在 AR 阳性 LNCaP,VCaP 和 22Rv1 前列腺癌细胞系中有效诱导 AR 蛋白降解,DC50值为 0.2-1 nM。
T17689 Boc-Pip-alkyne-Ph-COOH

Others Others
Boc-Pip-alkyne-Ph-COOH, a PROTAC linker characterized by its alkyl/ether composition, plays a crucial role in synthesizing PROTACs including ARD-266. This compound demonstrates significant efficacy in promoting the degradation of androgen receptor (AR) protein across AR-positive prostate cancer cell lines such as LNCaP, VCaP, and 22Rv1, showcasing DC50 values ranging from 0.2-1 nM[1].

化合物

ARD-266
Cat.No: T13552
Synonym:
Target: Others, PROTACs
AR antagonist 1
Cat.No: T10359
Synonym:
Target: Androgen Receptor, Ligand for E3 Ligase, Ligands for Target Protein for PROTAC
Pip-alkyne-Ph-COOCH3
Cat.No: T18545
Synonym:
Target: Others
VHL Ligand-Linker Conjugates 17
Cat.No: T18873
Synonym:
Target: Others
VHL Ligand 8
Cat.No: T13958
Synonym:
Target: Others
Boc-Pip-alkyne-Ph-COOH
Cat.No: T17689
Synonym:
Target: Others
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