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Search Results for " aif "

Targets Recommended: Dehydrogenase

5

抑制剂 & 化合物

3

天然产物

9

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T1979	AVN-944 VX-944	Dehydrogenase	Metabolism
	AVN-944 (VX-944) 是一种选择性的、非竞争性 IMPDH 抑制剂，对IMPDH1和IMPDH2的Ki=为6-10nM。
T34326	Ridaifen-B RidaifenB
	Ridaifen-B, a tamoxifen derivative, works by inducing independent autophagy of Bcl-2, without estrogen receptor involvement.
T71286	Guaifenesin-d3
	Guaifenesin-d3 is intended for use as an internal standard for the quantification of guaifenesin by GC- or LC-MS. Guaifenesin is an expectorant. It inhibits production of mucin 5AC (MUC5AC), reduces mucus viscosity and elasticity, and increases the mucociliary transport rate of endogenous particles in primary human tracheobronchial epithelial cells in a concentration-dependent manner. Guaifenesin increases phenol red secretion, a marker of expectorant activity, in rats.3 Formulations containing ...
T19710	Ciglitazone Ciglitazona,U 63287,ADD3878,ADD-3878,U-63287,ADD 3878	Apoptosis; p38 MAPK; PPAR	Apoptosis; DNA Damage/DNA Repair; MAPK; Metabolism
	Ciglitazone (ADD 3878) 是一种强效和选择性的PPARγ激动剂(EC50：3μM)和口服降糖药。Ciglitazone 抑制th17细胞的增殖和分化，降低胰岛素水平、血管内皮生长因子的产生和血压，诱导胃癌细胞的细胞周期停止。Ciglitazone 能诱导负鼠肾上皮细胞的凋亡，激活p38 MAPK 和凋亡诱导因子(AIF)的核转位。 Ciglitazone 在肥胖症和高血糖症的动物模型中表现出降血糖活性。
T78716	MKA031
	MKA031（compound 6y）作为一种非竞争性MIF抑制剂，展现出1.7 μM的IC50。该化合物能够阻断MIF/AIF相互作用、抑制MIF核内转移，并干预MNNG所诱发的细胞死亡。MKA031主要用于研究慢性丙型肝炎病毒感染。

化合物

Cat.No: T1979

Synonym: VX-944

Target: Dehydrogenase

Cat.No: T34326

Synonym: RidaifenB

Cat.No: T71286

Cat.No: T19710

Synonym: Ciglitazona,U 63287,ADD3878,ADD-3878,U-63287,ADD 3878

Target: Apoptosis, p38 MAPK, PPAR

Cat.No: T78716

Cat. No.	Product Name	Target	Signaling Pathways
T8678	Naphthazarin 萘茜,5,8-Dihydroxy-1,4-naphthoquinone,DHNQ	Apoptosis	Apoptosis
	Naphthazarin (5,8-Dihydroxy-1,4-naphthoquinone) 是来自毛紫草的一种天然产物，通过氧化应激、线粒体凋亡诱导因子的激活、微管的解聚、干扰溶酶体功能和 p53 依赖性 p21 激活，可触发细胞凋亡并具有抗肿瘤作用。
T0739	Guaifenesin Glycerol guaiacolate,Guaiacol glyceryl ether,愈创甘油醚,Guaiphenesin	Others	Others
	Guaifenesin (Guaiphenesin) 是一种祛痰剂，来自于 Guajacum officinale Linné 木材中。它可以增加痰液体积和降低其粘度，缓解咳嗽不适，促进有效的咳嗽。
T75485	Dehydrobruceine B
	Dehydrobruceine B 是一种苦木素，可从鸦胆子 (Brucea javanica) 中分离得到。Dehydrobruceine B 与 Cisplatin 通过线粒体途径，协同诱导细胞凋亡 (apoptosis)。Dehydrobruceine B 还增加凋亡诱导因子 (AIF) 和 Bax 表达，抑制 Keap1-Nrf2。

天然产物

Cat.No: T8678

Synonym: 萘茜,5,8-Dihydroxy-1,4-naphthoquinone,DHNQ

Target: Apoptosis

Cat.No: T0739

Synonym: Glycerol guaiacolate,Guaiacol glyceryl ether,愈创甘油醚,Guaiphenesin

Target: Others

Dehydrobruceine B

Cat.No: T75485

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-00718	AIF Protein, Human, Recombinant (His) AIF,Apoptosis-Inducing Factor 1 Mitochondrial,PDCD8...	Human	E. coli
	Apoptosis-Inducing Factor 1, Mitochondrial (AIFM1) is a flavoprotein essential for nuclear disassembly in apoptotic cells that is found in the mitochondrial intermembrane space in healthy cells. During apoptosis, it is translocated from the mitochondria to the nucleus to function as a proapoptotic factor in a caspase-independent pathway, while in normal mitochondria, it functions as an antiapoptotic factor via its oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces pa...
TMPY-03337	Iba1 Protein, Human, Recombinant (His) IRT1,IRT-1,AIF-1,allograft inflammatory factor 1,IB...	Human	E. coli
	AIF1, also known as IBA1, is an actin-binding protein. AIF1 is expressed selectively in human macrophage-like cell lines, and in a subset of CD68(+) macrophages in the interstitial and perivascular spaces of human heart allografts. It is expressed in macrophages and neutrophils. AIF1 enhances membrane ruffling and RAC activation. AIF1 enhances the actin-bundling activity of LCP1. It also enhances lymphocyte migration. AIF1 may play a role in macrophage activation and function. It binds calc...
TMPH-02500	AIF-1 Protein, Mouse, Recombinant (His) Allograft inflammatory factor 1,AIF1	Mouse	E. coli
	Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation. AIF-1 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The pred...
TMPH-00222	AIF-1 Protein, Bovine, Recombinant (His & Myc) Allograft inflammatory factor 1,AIF1	Bovine	E. coli
	May play a role in macrophage activation and function. AIF-1 Protein, Bovine, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 27.6 kDa and the accession number is Q9BDK2.
TMPY-01654	ITCH Protein, Human, Recombinant (aa 526-903) itchy E3 ubiquitin protein ligase,NAPP1,dJ468O1.1,ADMFD,...	Human	E. coli
	E3 ubiquitin-protein ligase Itchy homolog, also known as Atrophin-1-interacting protein 4, NFE2-associated polypeptide 1, NAPP1, and ITCH, is a cell membrane protein that contains one C2 domain, one HECT (E6AP-type E3 ubiquitin-protein ligase) domain and contains four WW domains. ITCH acts as an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It catalyzes 'Lys-...
TMPH-00021	Outer membrane protein Omp38, Acinetobacter baumannii, Recombinant (His)	Acinetobacter baumannii	P. pastoris (Yeast)
	Porin. Induces apoptosis in human cells through caspases-dependent and AIF-dependent pathways. Purified Omp38 enters the cells and localizes to the mitochondria, which leads to a release of proapoptotic molecules such as cytochrome c and AIF (apoptosis-inducing factor).
TMPH-00022	Outer membrane protein Omp38, Acinetobacter baumannii, Recombinant (His & SUMO)	Acinetobacter baumannii	E. coli
	Porin. Induces apoptosis in human cells through caspases-dependent and AIF-dependent pathways. Purified Omp38 enters the cells and localizes to the mitochondria, which leads to a release of proapoptotic molecules such as cytochrome c and AIF (apoptosis-inducing factor). Outer membrane protein Omp38, Acinetobacter baumannii, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 52.5 kDa and the accession number is A3M8K2.
TMPH-00023	Outer membrane protein Omp38, Acinetobacter baumannii, Recombinant (His & Myc)	Acinetobacter baumannii	E. coli
	Functions as a porin. Induces apoptosis in human cell lines through caspase-dependent and AIF-dependent pathways. Purified Omp38 enters host cell and localizes to the mitochondria, which presumably leads to a release of proapoptotic molecules such as cytochrome c and AIF (apoptosis-inducing factor). Binds peptidoglycan, contributes to cell wall maintenance (Probable). Outer membrane protein Omp38, Acinetobacter baumannii, Recombinant (His & Myc) is expressed in E. coli expression system with N-1...
TMPY-03439	UBASH3A Protein, Human, Recombinant (aa 354-623, His) TULA,STS-2,CLIP4,ubiquitin associated and SH3 domain contain...	Human	E. coli
	UBASH3A is a member of the T-cell ubiquitin ligand (TULA) family. This family consists of two members. Both of them can negatively regulate T-cell signaling. UBASH3A can facilitate growth factor withdrawal-induced apoptosis in T cells, which may occur via its interaction with AIF, an apoptosis-inducing factor. Alternative splicing of UBASH3A gene results in multiple transcript variants. It interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. UBASH3A pro...

重组蛋白

AIF Protein, Human, Recombinant (His)

Cat.No: TMPJ-00718

Species: Human

Expression System: E. coli

Iba1 Protein, Human, Recombinant (His)

Cat.No: TMPY-03337

Species: Human

Expression System: E. coli

AIF-1 Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02500

Species: Mouse

Expression System: E. coli

AIF-1 Protein, Bovine, Recombinant (His & Myc)

Cat.No: TMPH-00222

Species: Bovine

Expression System: E. coli

ITCH Protein, Human, Recombinant (aa 526-903)

Cat.No: TMPY-01654

Species: Human

Expression System: E. coli

Outer membrane protein Omp38, Acinetobacter baumannii, Recombinant (His)

Cat.No: TMPH-00021

Species: Acinetobacter baumannii

Expression System: P. pastoris (Yeast)

Outer membrane protein Omp38, Acinetobacter baumannii, Recombinant (His & SUMO)

Cat.No: TMPH-00022

Species: Acinetobacter baumannii

Expression System: E. coli

Outer membrane protein Omp38, Acinetobacter baumannii, Recombinant (His & Myc)

Cat.No: TMPH-00023

Species: Acinetobacter baumannii

Expression System: E. coli

UBASH3A Protein, Human, Recombinant (aa 354-623, His)

Cat.No: TMPY-03439

Species: Human

Expression System: E. coli

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