Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T8961 |
GW280264X
Carbamic acid |
MMP | Proteases/Proteasome |
GW280264X (Carbamic acid) 是一种 ADAM10/TACE (ADAM17)金属蛋白酶抑制剂。它有效阻断 TACE (ADAM17)和 ADAM10的 IC50分别为 8.0 nM 和 11.5 nM。其中ADAM10/17 能够调节胶质母细胞瘤起始细胞的免疫原性。 | |||
T7522 |
GI254023X
GI 254023X |
MMP; Immunology/Inflammation related | Immunology/Inflammation; Proteases/Proteasome |
GI254023X 是MMP9和ADAM10抑制剂,它们的IC50s 分别为 2.5 和 5.3 nM。 | |||
T27603 |
INCB3619
INCB-3619,INCB 3619 |
Immunology/Inflammation related | Immunology/Inflammation |
INCB3619 是一种具有选择性和高效性的 ADAM 的抑制剂,具有抗肿瘤作用,抑制 ADAM10、ADAM17、MMP12 和 MMP15。 | |||
T27654 |
JG26
JG 26,JG-26 |
MMP; Immunology/Inflammation related | Immunology/Inflammation; Proteases/Proteasome |
JG26 是一种强效的 ADAM17 抑制剂,对 ADAM8、ADAM17、ADAM10 和 MMP-12 均有抑制作用,其 IC50 值分别为 12 nM、1.9 nM、150 nM 和 9.4 nM,可用于研究机体免疫系统。 | |||
T40901 |
Aderbasib
INCB007839,INCB7839 |
||
Aderbasib (INCB007839) is a highly potent and orally active hydroxamate-based inhibitor of ADAM10 and ADAM17, with low nanomolar affinity. This compound demonstrates strong antineoplastic activity and holds potential for cancer research in various areas, such as diffuse large B-cell non-Hodgkin lymphoma, HER2-positive breast cancer, gliomas, and more. | |||
T28985 |
TMI-1
WAY-171318 |
Apoptosis; MMP | Apoptosis; Proteases/Proteasome |
TMI-1 (WAY-171318) 是一种有效的抑制剂,用于抑制去整合素金属酶17 (ADAM17) 和其他基质金属蛋白酶MMPs。TMI-1 能够有效地抑制LPS 诱导的人原代单核细胞和人全血中TNF-α的分泌。TMI-1 在三阴性 (TN) 和过度表达ERBB2的乳腺肿瘤细胞系中选择性地诱导Caspase 依赖的细胞凋亡。 |