Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T14073 |
A-485
|
Epigenetic Reader Domain; Histone Acetyltransferase | Chromatin/Epigenetic |
A-485 是 p300/CBP 的一种选择性催化抑制剂,对 p300和 CBP 组蛋白乙酰转移酶的 IC50值分别为 9.8 和 2.6 nM。 | |||
T79758 |
BQZ-485
|
Apoptosis | Apoptosis |
BQZ-485是一种有效的GDI2抑制剂,它通过与Tyr245相互作用以破坏GDI2-Rab1A之间的内在相互作用,阻断了从内质网(ER)至高尔基体的囊泡转运,并触发了随后的凋亡事件。 | |||
T69889 | JBP485 | ||
JBP485 is an inhibitor of renal transporters OAT1 and OAT3. JBP485 is an antihepatitis agent as a substrate for intestinal PEPT1. | |||
T8838 |
CCI-007
|
Apoptosis; Histone Methyltransferase | Apoptosis; Chromatin/Epigenetic |
CCI 007 是一种具有细胞毒性的选择性白血病抑制剂,在MLL 重排的敏感系婴幼儿白血病细胞中,IC50为2.5-6.2 μM。 | |||
T29536 |
AC 485
AC-485,AC485 |
||
AC 485 is a biochemical. | |||
T18993 |
Fluorescein di(β-D-galactopyranoside)
FDG |
Others | Others |
Fluorescein di(β-D-galactopyranoside) is a fluorogenic substrate for β-galactosidase (λem=535 nm, λex=485 nm). | |||
T37656 |
MIT-PZR
|
||
MIT-PZR is a mitochondria-targeted fluorescent probe.1It is aggregation-induced emission (AIE) active and displays absorption/emission maxima of 485/705 nm, respectively. MIT-PZR can be used in live cells andin vivo. 1.Dong, Y., Chen, Z., Hou, L., et al.Mitochondria-targeted aggregation-induced emission active near infrared fluorescent probe for real-time imagingSpectrochim. Acta. A. Mol. Biomol. Spectrosc.224117456(2019) | |||
T38370 |
CAY10731
|
||
CAY10731 is a fluorescent probe for hydrogen sulfide (H2S).[1] Upon reaction with H2S, fluorescein (FITC) is released and its fluorescence can be used to detect H2S. FITC displays excitation/emission maxima of 485/535 nm, respectively. CAY10731 is selective for H2S over glutathione (GSH), cysteine, H2O3-, SO3-, and H2O2 as well as tBuO and OH radicals. It has been used to detect H2S in rat hippocampal slices and nematodes. | |||
T40210 |
eIF4E-IN-3
eIF4E-IN-3 |
||
eIF4E-IN-3 is a highly effective inhibitor of eukaryotic initiation factor 4e (eIF4e), exhibiting noteworthy potential for investigating eIF4e dependent diseases, particularly cancer research (WO2021003157A1, compound 485). | |||
T41172 |
FAM-DEALA-Hyp-YIPD
|
||
FAM-DEALA-Hyp-YIPD is a fluorescent HIF-1α peptide (Kd= 180-560 nM). Can be used to assess VHL binding in Fluorescence Polarization (FP) displacement assay, and evaluate the effect of VHL binding on degradation activity. Excitation maximum = 485 nm, emission maximum = 535 nm. Longer peptide version, FAM-DEALAHypYIPMDDDFQLRSF, also available. | |||
T35880 | Renin Fluorogenic Substrate | ||
The renin fluorogenic substrate consists of the normal peptide substrate for renin which has been linked to the fluorophore EDANS at one end and to a non-fluorescent quenching molecule (Dabcyl) at the other. After cleavage by renin, the product (peptide-EDANS) is brightly fluorescent and can be easily analyzed using an excitation wavelength of 340 nm and emission wavelengths of 485-510 nm. | |||
T37090 |
Indo-1 (potassium salt)
|
||
Indo-1 (potassium salt) is a ratiometric fluorescent calcium indicator. It is ideal for analyses using flow cytometry, as it uses a single excitation source, typically 349-364 nm light from an argon-ion laser. The emission maximum shifts from 475-485 nm without calcium to 400-410 nm when Indo-1 (potassium salt) binds calcium. Indo-1 (potassium salt) is prone to photobleaching, which limits its usefulness in methods involving microscopy. | |||
T82811 |
BTC tetrapotassium
|
||
BTC tetrapotassium是一种钙指示剂,其Kd值约为7-26 µM,表现出低亲和力。它拥有适合细胞钙成像的特性,如长激发波长(400/485 nm),低对Mg2+的灵敏度,以及用于比率测量的高准确性。 | |||
T41173 |
FAM-DEALAHypYIPMDDDFQLRSF
|
||
FAM-DEALAHypYIPMDDDFQLRSF is a 5,6-carboxyfluorescein (FAM) labeled HIF-1α peptide. It binds with high affinity to von Hippel-Lindau (VHL) protein (KD= 3 nM). Can be used to assess ligand binding to VHL in a direct fluorescence polarization (FP) displacement assay. Excitation/emission maxima (λ) = 485/520 nm. This product is a longer peptide version of FAM-DEALA-Hyp-YIPD. | |||
T37091 |
Indo-1 (sodium salt)
|
||
Indo-1 (sodium salt) is a ratiometric fluorescent calcium indicator. It is ideal for analyses using flow cytometry, as it uses a single excitation source, typically 349-364 nm light from an argon-ion laser. The emission maximum shifts from 475-485 nm without calcium to 400-410 nm when Indo-1 (sodium salt) binds calcium. Indo-1 (sodium salt) is prone to photobleaching, which limits its usefulness in methods involving microscopy. | |||
T63980 |
BODIPY FL prazosin
|
||
BODIPY FL prazosin 是荧光 α1-肾上腺素 α1-adrenergic 拮抗剂,能够作用于 α1a-AR (Ki: 14.5 nM)和 α1b-AR (Ki: 43.3 nM)。BODIPY FL prazosin 是一种荧光配体,激发和发射波长分别为 485 和 535 nm。BODIPY FL prazosin 能够用于 α1-肾上腺素受体亚型的亚细胞定位差异的研究。 | |||
T35549 |
Elsinochrome A
|
||
Elsinochrome A is a perylenequinone fungal metabolite that has been found inHypomycesand has anticancer activity.1Photoactivation of elsinochrome A induces the production of singlet oxygen and apoptosis in R366.4 rhesus monkey embryonic stem cells and HCe-8693 colorectal carcinoma cells when used at concentrations ranging from 1 to 100 μM. 1.Ma, L., Tai, H., Li, C., et al.Photodynamic inhibitory effects of three perylenequinones on human colorectal carcinoma cell line and primate embryonic stem ... |