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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T2711	Chembridge-5861528 TCS 5861528	TRP/TRPV Channel	Membrane transporter/Ion channel
	Chembridge-5861528 (TCS 5861528) 是有效的 TRPA1离子通道阻断剂。
T35971	4-hydroxy Nonenal Mercapturic Acid
	Peroxidation of common ω-6 polyunsaturated fatty acids (PUFAs) such as linoleic acid, DGLA, and arachidonic acid can give rise to 4-HNE. 4-HNE is cleared rapidly from the plasma and undergoes enterohepatic circulation as a glutathione conjugate in the rat. About two thirds of an administered dose of 4-HNE is excreted within 48 hours in the urine, primarily in the form of mercapturic acid conjugates. The C-1 aldehyde of 4-HNE is reduced to an alcohol in about half of these metabolites. The remain...
T35970	4-hydroxy Nonenal Alkyne
	4-hydroxy Nonenal (4-HNE) is a major aldehyde produced during the lipid peroxidation of ω-6 polyunsaturated fatty acids, such as arachidonic acid and linoleic acid. It is considered a potential causal agent in numerous diseases, including chronic inflammation, neurodegenerative diseases, atherosclerosis, diabetes, and cancer, in part because it covalently modifies DNA and proteins resulting in genetic mutations and altered cell signaling, respectively. 4-HNE Alkyne is a form of 4-HNE with a term...
T36001	4-hydroperoxy 2-Nonenal
	4-hydroxy Nonenal is a lipid peroxidation product derived from oxidized ω-6 polyunsaturated fatty acids, such as linoleic acid and arachidonic acid, that is widely used as a marker of oxidative stress. 4-HNE exhibits various biological activities such as cytotoxicity, growth inhibiting activity, genotoxicity, and chemotactic activity. 4-hydroperoxy 2-Nonenal is the immediate precursor of 4-HNE formed from the cleavage of ω-6 hydroperoxides. Analogous reactions are expected to occur with hydroper...
T79397	Neutrophil elastase inhibitor 4
	Neutrophilelastase inhibitor4 (compound 4f) 是竞争性抑制HNE的化合物，具有较低的半抑制浓度(IC50: 42.30 nM)和解离常数(Ki: 8.04 nM)。此外，该化合物能够诱导T47D细胞的apoptosis，并在多种细胞系中展现出抗增殖作用，分别在T47D、RPMI 8226、A549、HSF细胞系的IC50值为21.25、34.17、29.93、99.11 nM。

化合物

Chembridge-5861528

Cat.No: T2711

Synonym: TCS 5861528

Target: TRP/TRPV Channel

4-hydroxy Nonenal Mercapturic Acid

Cat.No: T35971

Synonym:

Target:

4-hydroxy Nonenal Alkyne

Cat.No: T35970

Synonym:

Target:

4-hydroperoxy 2-Nonenal

Cat.No: T36001

Synonym:

Target:

Neutrophil elastase inhibitor 4

Cat.No: T79397

Synonym:

Target:

Cat. No.	Product Name	Target	Signaling Pathways
T10148	4-Hydroxynonenal 4-羟基壬烯醛,4-HNE	Dehydrogenase; Endogenous Metabolite	Metabolism
	4-Hydroxynonenal (4-HNE) 是一种 α，β 不饱和羟基烯醛，可作为氧化/亚硝化应激生物标志物。它是ALDH2的底物和抑制剂。它可以调节许多信号传导过程，主要是通过与蛋白质，核酸和膜脂质中具有亲核官能团的共价加合物形成的。它通过线粒体在癌症中起重要作用。
TN4582	Moracin T	c-Myc; COX	Cell Cycle/Checkpoint; Immunology/Inflammation; Neuroscience
	Moracin treatment can inhibit the double 12-O-tetradecanoylphorbol 13-acetate (TPA) treatment-induced morphological changes reflecting inflammatory response, including leucocyte infiltration, hyperplasia and cell proliferation; moracin treatment furthermo