Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T24963 |
10-Methyl-10-deazaaminopterin
|
Others | Others |
10-Methyl-10-deazaaminopterin is a folate analog that shows antitumor activity. | |||
T6120 |
Pralatrexate
Folotyn,10-炔丙基-10-去氮杂氨基蝶呤,10-Propargyl-10-deazaaminopterin,普拉曲沙 |
Apoptosis; DHFR; Antifolate; TAM Receptor | Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Tyrosine Kinase/Adaptors |
Pralatrexate (10-Propargyl-10-deazaaminopterin) 是一种抗叶酸剂,也是二氢叶酸还原酶抑制剂,Ki 值为 13.4 pM。它具有抗肿瘤活性,可研究复发/难治性 T 细胞淋巴瘤。它是叶酰聚谷氨酸合成酶的底物,具有改善的细胞摄取和保留能力。 | |||
T24961 |
10-Deazaaminopterin
NSC 311469,NSC-311469,10-Deaza-aminopterin,NSC311469 |
Others | Others |
10-Deazaaminopterin is a poly-gamma-glutamyl metabolite of the experimental anticancer drug, a folic acid antagonist, antineoplastic agent enzyme inhibitor. | |||
T68661 |
Edatrexate
CGP 30694 |
Others | Others |
Edatrexate (CGP 30694),即 10-乙基-10-去甲氨基蝶呤,是甲氨蝶呤Methotrexate 的类似物,对耐 MTX 肿瘤具有抗肿瘤活性。Edatrexate 是一种抗叶酸抗代谢物,可用于研究非小细胞肺癌,乳腺癌,非霍奇金淋巴瘤和头颈部癌症的研究。 |