Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T10523 |
β3-AR agonist 1
|
Others | Others |
β3-AR agonist 1 is a highly selective, and orally available agonist of β3-adrenergic receptor (EC50: 18 nM), being inactive to β1-, β2-, and α1A-AR (β1/β3, β2/β3, and α1A/β3>556-fold). | |||
T11804 |
β3-AR agonist 2
|
Others | Others |
β3-AR agonist 2 is a potent and selective agonist of β3-adrenergic receptor (β3-AR with an EC50 of 8 nM). | |||
T6872 |
L755507
|
Adrenergic Receptor; CRISPR/Cas9 | DNA Damage/DNA Repair; GPCR/G Protein; Neuroscience |
L755507 是一种有效的选择性β3-AR 激动剂,IC50值为 35 nM。 | |||
T12970 |
Solabegron
GW 427353,3'-[[2-[(2R)-2-(3-氯苯基)-2-羟基乙基]氨基]乙基]氨基]-[1,1'-联苯基]-3-羧酸 |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Solabegron (GW 427353) 是一种β3肾上腺素能受体 (β3-AR)的选择性激动剂, 在中国仓鼠卵巢细胞中测得 EC50=22 nM,可用于研究膀胱过度活跃和肠易激综合征。 | |||
T34333 |
Ritobegron HCl
KUC7483,KUC 7483,KUC-7483,Ritobegron,Ritobegron hydrochloride |
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Ritobegron (KUC-7483), an effective and selective β3-adrenergic receptor agonist, shows effective β(3)-AR agonist activity on transfected human β-AR and has an effect on the bladder of rats Shows high selectivity with other organs. | |||
T63356 |
Bopindolol fumarate
|
||
Bopindolol ((±)-Bopindolol) fumarate 是一种具有部分激动剂活性的、口服具有活力的 β-肾上腺素受体 (ARs) 拮抗剂,对 β1- 和 β2-ARs 无选择性,对 β3-AR 亚型亲和力低。Bopindolol fumarate 是 Pindolol 的前体药物,能够用于研究原发性和肾血管性高血压。 | |||
T9451 |
Bopindolol
|
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Bopindolol 是一种口服活性的 β-肾上腺素受体 (ARs) 拮抗剂,具有部分激动剂活性。Bopindolol 对 β1- 和 β2-ARs 无选择性,对β3-AR 亚型亲和力低。Bopindolol 是 Pindolol 的前体药物,可迅速代谢为活性水解形式。Bopindolol 可用于原发性和肾血管性高血压的研究。 |