Powder: -20°C for 3 years | In solvent: -80°C for 1 year
L755507 是一种有效的选择性β3-AR 激动剂,IC50值为 35 nM。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 297 | 现货 | ||
5 mg | ¥ 690 | 现货 | ||
10 mg | ¥ 995 | 现货 | ||
25 mg | ¥ 2,480 | 现货 | ||
50 mg | ¥ 3,680 | 现货 | ||
100 mg | ¥ 5,230 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 888 | 现货 |
产品描述 | L755507 is an effective, selective agonist of β3-AR(IC50=35 nM). |
靶点活性 | β3-AR:35 nM |
体外活性 | L-755,507 displays an excellent activity profile as an extremely potent human β3 adrenergic receptor agonist (β3 EC50 0.43 nM), with >440-fold selectivity over β1 and β2 binding[1]. L755507 causes a robust concentration-dependent increase in cAMP accumulation in CHO-K1 cells expressing human β3-adrenoceptors(pEC50 values of 12.3)[4]. In a recent study employing a high-throughput screen to identify chemicals capable of modulating HR-mediated genome editing, L-755507 is identified that could enhance HR repair by up to ninefold[3]. |
体内活性 | Acute exposure of rhesus monkeys to L-755,507 elicits lipolysis and metabolic rate elevation, and that chronic exposure increases uncoupling protein 1 expression in rhesus brown adipose tissue[2]. |
分子量 | 584.73 |
分子式 | C30H40N4O6S |
CAS No. | 159182-43-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 58.5 mg/mL (100 mM)
Ethanol: 58.5 mg/mL (100 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO / Ethanol | 1 mM | 1.7102 mL | 8.551 mL | 17.1019 mL | 42.7548 mL |
5 mM | 0.342 mL | 1.7102 mL | 3.4204 mL | 8.551 mL | |
10 mM | 0.171 mL | 0.8551 mL | 1.7102 mL | 4.2755 mL | |
20 mM | 0.0855 mL | 0.4275 mL | 0.8551 mL | 2.1377 mL | |
50 mM | 0.0342 mL | 0.171 mL | 0.342 mL | 0.8551 mL | |
100 mM | 0.0171 mL | 0.0855 mL | 0.171 mL | 0.4275 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
L755507 159182-43-1 DNA Damage/DNA Repair GPCR/G Protein Neuroscience CRISPR/Cas9 Adrenergic Receptor HDR β3-AR inhibit Beta Receptor Inhibitor L-755507 L 755507 inhibitor