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Cat. No. | Product Name | Target | Signaling Pathways |
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T7813 |
α-MSH
MSH, amide,CZEN-002,美拉诺坦,α-Melanocyte-Stimulating Hormone (MSH), amide |
Melanocortin Receptor; Adenylyl cyclase | GPCR/G Protein; Neuroscience |
α-MSH (MSH, amide) 是一种内源性神经肽,是一种内源性黑皮质素受体 4 (MC4R) 激动剂,具有抗炎和解热活性。 | |||
T35406 |
α-MSH TFA
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α-Melanocyte-stimulating hormone (α-MSH) is a 13-amino acid peptide hormone produced by post-translational processing of proopiomelanocortin (POMC) in the pituitary gland, as well as in keratinocytes, astrocytes, monocytes, and gastrointestinal cells.1It is an agonist of melanocortin receptor 3 (MC3R) and MC4R that induces cAMP production in Hepa cells expressing the human receptors (EC50s = 0.16 and 56 nM, respectively).2α-MSH (100 pM) reducesS. aureuscolony formation andC. albicansgerm tube fo... | |||
TP1097 |
Melanotan I
美拉诺坦,美拉诺坦 I,[Nle4,D-Phe7]-α-MSH,Afamelanotide,MT-I |
Others | Others |
Melanotan I 是一种非特异性黑素皮质激素受体 (MCR) 激动剂, 是一种 α- 黑素细胞刺激激素 (α-MSH) 类似物,皮下注射可增加黑色素在皮肤中的含量。Melanotan I 可用于辅助美黑。Melanotan I 可用于预防阳光诱发皮肤癌,可用于研究黑色素瘤和男性勃起功能障碍。 | |||
T8566 |
AA92593
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Others | Others |
AA92593 是一种选择性的 OPN4 (melanopsin)竞争性拮抗剂。 | |||
T7589 |
Afamelanotide acetate
afamelanotide |
Melanocortin Receptor | GPCR/G Protein; Neuroscience |
Afamelanotide acetate 是一种合成的 α-黑素细胞刺激激素类似物和一流的黑皮质素-1 受体激动剂,用于治疗红细胞生成性原卟啉症。 | |||
T76340 |
(Nle4)-α-MSH
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(Nle4)-α-MSH 是一种黑素细胞刺激激素α-MSH 的合成类似物。(Nle4)-α-MSH 能够使青蛙皮肤可逆变黑,并在热碱处理后表现出延长的活性。 | |||
TP2212L |
a-MSH, amide Acetate(581-05-5 free base)
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Melanocortin Receptor | GPCR/G Protein; Neuroscience |
a-MSH, amide Acetate(581-05-5 free base) 是一种内源性黑皮质素受体 4 (MC4R) 激动剂,具有抗炎和解热活性。 α-MSH 是阿片黑皮质素原 (POMC) 的翻译后衍生物。 | |||
TP1893L1 |
[D-Trp8]-γ-MSH acetate(321351-81-9 free base)
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Melanocortin Receptor | GPCR/G Protein; Neuroscience |
[D-Trp8]-γ-MSH acetate(321351-81-9 free base) 是选择性黑皮质素 3 (MC3) 受体激动剂(对人 MC3、MC5 和 MC4 受体的 IC50 值分别为 6.7、340 和 600 nM)。显示有抗炎功效。 | |||
TP1002L |
γ-1-MSH, amide acetate (72629-65-3 free base)
γ-1-MSH, amide acetate |
Others | Others |
γ-1-MSH, amide acetate (72629-65-3 free base) 是 ACTH/β-内啡肽 (β-EP) 前体蛋白 N 末端区域的一种推定激素,RIA 使用抗 γ-3-MSH 抗血清对产生 ACTH 的小鼠进行了研究垂体肿瘤细胞,AtT-20/D16v。 | |||
T76346 |
(D-Phe7)-α-MSH
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(D-Phe7)-α-MSH 是一种 α-MSH 类似物。 | |||
T83188 |
Acetyl-α-MSH (11-13)
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Acetyl-α-MSH (11-13)为α-MSH C端三肽的乙酰化形式,展现解热及抗炎特性。 | |||
T76347 |
Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2
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Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 是一种促黑素激素,能够激活黑素细胞。该化合物具有促进酪氨酸酶活性的功能,并在大鼠模型中显示出调节体温的效果。 | |||
T80687 |
γ3-MSH
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γ3-MSH 源于 pro-opiomelanocortin (POMC) 的 N 端,能够激活人肾上腺肿瘤细胞分泌醛固酮。 | |||
T75851 |
γ1-MSH TFA
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γ1-MSH TFA 是黑素皮质素 MC3受体激动剂,对大鼠 MC3受体的 Ki 为 34 nM。γ1-MSH TFA 在 MC4 (Ki=1318 nM) 上表现出约 40 倍的选择性。 | |||
T75965 |
β-Melanocyte Stimulating Hormone (MSH), human TFA
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β-Melanocyte Stimulating Hormone (MSH), human TFA,为一种具有22个氨基酸残基的肽类化合物,是内源性黑皮质素-4 受体(melanocortin-4 receptor; MC4-R)的激动剂。 | |||
T75854 |
[D-Trp8]-γ-MSH TFA
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[D-Trp8]-γ-MSH TFA 是一种有效的、选择性的黑皮质素3 (MC3)受体激动剂,在 CHO 细胞中,抑制 hMC3,hMC4和 hMC5的 IC50值分别为 6.7 nM,600 nM 和 340 nM。[D-Trp8]-γ-MSH TFA 显示出对多种炎症性疾病(如类风湿关节炎和结肠炎)的保护作用。 | |||
T75849 |
Lys-γ3-MSH(human) TFA
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Lys-γ3-MSH(human) TFA是源自POMC片段C端的黑素皮质素肽,具备增强大鼠肾上腺对促肾上腺皮质激素(ACTH)的类固醇生成反应的能力。该化合物作为一种有效的脂解激活剂,其表观EC50值为3.56 nM,能够激活激素敏感脂肪酶(HSL)和紫苏脂素A,进而促进脂解。 | |||
T75971 |
γ-1-Melanocyte Stimulating Hormone (MSH), amide
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γ-1-Melanocyte Stimulating Hormone (MSH), amide为含11个氨基酸的多肽,主要通过激活黑皮质素受体3 (MC3-R) 调节钠 (Na+) 平衡及血压。 | |||
TP1101 |
Nonapeptide-1 acetate salt (158563-45-2 free base)
Melanostatine-5 acetate salt,Nonapeptide-1 acetate salt |
Melanocortin Receptor | GPCR/G Protein; Neuroscience |
Nonapeptide-1 acetate salt (158563-45-2 free base) (Melanostatine-5 acetate salt) 是一种肽激素,是一种有效的 α-黑色素细胞刺激素 (α-MSH) 拮抗剂,IC50 为 11 nM。 | |||
TP1245L |
ACTH 4-11 acetate
ACTH 4-11 acetate (67224-41-3 Free base) |
Others | Others |
ACTH 4-11 acetate 是一种促肾上腺皮质激素片段,具有与 α-黑素细胞刺激素 (MSH) 相同的氨基酸序列。 ACTH 4-11 acetate 仅在高剂量时表现出微弱的 MSH 效力。 | |||
TP1324 |
Melanotan (MT)-II
美拉诺坦 II,美拉诺坦 (MT)-II |
Melanocortin Receptor | GPCR/G Protein; Neuroscience |
Melanotan (MT)-II 是一种可注射用的多肽荷尔蒙,是合成的黑皮质素受体激动剂,能够促进晒黑。 | |||
TP1244L1 |
Adrenocorticotropic Hormone (ACTH) (1-10), human acetate
Adrenocorticotropic Hormone (ACTH) (1-10), human acetate(2791-05-1 Free base) |
Others | Others |
Adrenocorticotropic Hormone (ACTH) (1-10), human acetate 是促肾上腺皮质激素的一个片段。 Adrenocorticotropic Hormone (ACTH) (1-10), human acetate 仅在 100 和 1000 nM 时具有较弱的 α-MSH 效力。 | |||
T20501 |
Undecylenoyl phenylalanine
Undecylenoylphenylalanine,Sepiwhite msh QD,Sepiwhite msh,十一碳烯酰基苯丙氨酸 |
Melanocortin Receptor | GPCR/G Protein; Neuroscience |
Undecylenoyl phenylalanine (Sepiwhite msh QD) 是一种新型脱色剂,可能作为 α-黑色素细胞刺激激素拮抗剂,从而抑制黑色素生成。 | |||
T7608 |
Bremelanotide Acetate
bremelanotide,PT-141 Acetate |
Melanocortin Receptor | GPCR/G Protein; Neuroscience |
Bremelanotide Acetate (PT-141 Acetate) 是 α-MSH 的合成肽类似物,是黑素皮质素受体 MC3R 和 MC4R 的激动剂,有用于性功能障碍的研究潜力。 | |||
TP1898 |
HS024
HS 024 |
Melanocortin Receptor | GPCR/G Protein; Neuroscience |
HS024 是一种选择性的MC4受体拮抗剂,可增加食物摄入,对 MC4、MC5、MC3 和 MC1 的Ki 分别为 0.29、3.29、5.45 和 18.6 nM。 | |||
T5464 |
JNJ-10229570
JNJ10229570,UNII-N9IX402L35,JNJ 10229570 |
Melanocortin Receptor | GPCR/G Protein; Neuroscience |
JNJ-10229570 (UNII-N9IX402L35) 是肾上腺皮质受体 1 和肾上腺皮质受体 5 的拮抗剂,可抑制皮脂腺分化和皮质特异性脂质的产生,其抑制125I-NDP-α-MSH 和人类细胞中 MC1R 和 MC5R 结合的IC50值分别为 270 nM 和 200 nM。 | |||
TP2212 |
a-MSH, amide
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Others | Others |
a-MSH, amide is a peptide with the sequence Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2, MW= 1664.9. The melanocyte-stimulating hormones (collectively referred to as MSH or intermedins) are a class of peptide hormones that are produced by c | |||
TP1244 |
Adrenocorticotropic Hormone (ACTH) (1-10), human
ACTH (1-10), human |
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Adrenocorticotropic Hormone (ACTH) (1-10), human is a fragment of the adrenocorticotropin hormone. It exhibits a weak potency of α-melanocyte stimulating hormone (α-MSH), but only at high doses (100 and 1000 nM). | |||
T76642 |
Acetyl-ACTH (2-24) (human, bovine, rat)
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Acetyl-ACTH (2-24) (human, bovine, rat) 是原黑色素皮质素 (POMC) 肽的片段。POMC 肽,如促肾上腺皮质激素(ACTH),是α-MSH 的前体,也是MC-1受体的激动剂。 | |||
T68328 |
Modimelanotide
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Modimelanotide is a melanocortinergic peptide drug derived from α-melanocyte-stimulating hormone (α-MSH) which was under development for the treatment of acute kidney injury. It acts as a non-selective melanocortin receptor agonist. | |||
T76643 |
Acetyl-ACTH (3-24) (human, bovine, rat)
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Acetyl-ACTH (3-24) (human, bovine, rat) 是原黑色素皮质素 (POMC) 肽的片段。POMC 肽,如促肾上腺皮质激素(ACTH),是α-MSH 的前体,也是 MC-1 受体的激动剂。 | |||
T80207 |
Tetrapeptide
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DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
Tetrapeptide 作为α-MSH的类似物,能促进黑色素的合成;其通过降低活性氧化物质生成和提升DNA光产物修复效率,有效减轻DNA损伤。 | |||
T76072 |
CCZ01048
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CCZ01048 是一种 α-MSH 类似物,与黑素皮质素 1 受体(MC1R)具有很高的结合亲和力,Ki 值为 0.31 nM。CCZ01048 具有快速内化 B16F10 黑色素瘤细胞和高体内稳定性。CCZ01048 是恶性黑色素瘤 PET 显像的一个有前途的制剂。 | |||
TP2011 |
JKC363
JKC 363 |
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Potent and selective melanocortin MC4 receptor antagonist (IC50 values are 0.5 and 44.9 nM at MC4 and MC3 respectively) that antagonizes the effects of α-MSH. Suppresses thyrotropin-releasing hormone (TRH) release, attenuates food intake and reduces forma | |||
T76644 |
Acetyl-ACTH (4-24) (human, bovine, rat)
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Acetyl-ACTH (4-24) (human, bovine, rat) 是原黑色素皮质素 (POMC) 肽的片段。POMC 肽,如促肾上腺皮质激素(ACTH),是α-MSH 的前体,也是 MC-1受体的激动剂。 | |||
T75850 |
JKC363 TFA
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JKC363 TFA为选择性MC4受体拮抗剂,MC4受体(IC50=0.5 nM)亲和力是MC3受体(44.9 nM)的90倍。JKC363 TFA能阻断α-MSH对TRH释放的刺激,显示出抗痛觉效果。 | |||
T76303 |
(p-Iodo-Phe7)-ACTH (4-10)
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'(p-Iodo-Phe7)-ACTH (4-10)'为垂体前腺产生和分泌的肾上腺皮质激素(ACTH)衍生物,担任黑素皮质素(MC)受体拮抗剂角色,能够抑制α-黑素细胞刺激激素(α-MSH)引发的大鼠过度梳理行为。 | |||
T75715 |
Nonapeptide-1 acetate salt
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Nonapeptide-1 (Melanostatine-5) acetate salt,一种多肽类激素,是 MC1R 选择性拮抗剂 (Ki: 40 nM)。 Nonapeptide-1 acetate salt 是一种竞争性的α-MSH 拮抗剂,可有效抑制黑素细胞中 α-MSH 诱导的细胞内 cAMP 和黑素体扩散 (IC50分别为 2.5 nM 和 11 nM)。 Nonapeptide-1 acetate salt 抑制黑色素合成,可用于研究皮肤色素沉着和肾上腺类固醇生成的调节、皮肤癌。 | |||
T76072L |
CCZ01048 TFA
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CCZ01048 TFA 是一种 α-MSH 类似物,与黑素皮质素1受体(MC1R)具有很高的结合亲和力,Ki 值为 0.31 nM。CCZ01048 TFA 具有快速内化 B16F10 黑色素瘤细胞和高体内稳定性。CCZ01048 TFA 是恶性黑色素瘤 PET 显像的一个有前途的制剂。 | |||
T35460 |
β-Endorphin (rat)
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β-Endorphin (β-EP) is an endogenous opioid neuropeptide with diverse biological activities. It is produced via piomelanocortin cleavage in the pituitary gland, hypothalamus, and in lymphocytes, then migrates to its sites of action which include plasma, gut, skin, placenta, cerebrospinal fluid, and cardiac tissues. β-EP induces concentration-dependent decreases in electrically stimulated contraction of the mouse vas deferens that can be reversed by the μ-opioid antagonist CTP and δ-opioid antagon... |
Cat. No. | Product Name | Target | Signaling Pathways |
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T2S0799 | Noroxyhydrastinine | Tyrosinase | Proteases/Proteasome |
Noroxyhydrastinine exhibits potent melanogenesis-inhibitory activities, it inhibits melanogenesis, at least in part, by inhibiting the expression of protein levels of tyrosinase, TRP-1, and TRP-2 in α-MSH-stimulated B16 melanoma cells. | |||
TN3723 | Cryptomeridiol | PAFR; Antifection | GPCR/G Protein; Microbiology/Virology |
Cryptomeridiol is a potential skin-whitening agent, exhibits melanogenesis inhibitory activity on α-MSH-stimulated B16 melanoma cells. Cryptomeridiol has low activity against A. niger, T. mentagrophytes, and C. albicans. (-)-Cryptomeridiol also exhibits a significant and concentration-dependent inhibitory effect on PAF receptor binding, with inhibitory concentration (IC)(50) values of 17.5 uM. |