Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T12644 |
(R)-Thalidomide
(R)-(+)-Thalidomide |
Others | Others |
(R)-Thalidomide is the R-enantiomer of Thalidomide, has sedative properties. | |||
T7791 |
Iberdomide
CC-220 |
Apoptosis; Ligand for E3 Ligase | Apoptosis; PROTAC |
Iberdomide (CC-220) 是一种口服有效的 cereblon E3 连接酶调节剂,对 cereblon 结合亲和力的 IC50约为150 nM。它是沙利度胺的衍生物,具有抗肿瘤和免疫刺激活性。 | |||
T36249 |
Thalidomide 4'-ether-PEG3-amine
Thalidomide 4'-ether-PEG3-amine |
||
Functionalized cereblon ligand for PROTAC research and development; incorporates an E3 ligase ligand plus a short PEG linker ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D. This product has been recently renamed. The previous name for this product was Thalidomide - linker 11 PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license. | |||
T36276 |
Thalidomide 4'-oxyacetamide-alkylC8-amine
Thalidomide 4'-oxyacetamide-alkylC8-amine |
||
Functionalized cereblon ligand for PROTAC research and development; incorporates an E3 ligase ligand plus an alkylC8 linker with terminal amine ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D. This product has been recently renamed. The previous name for this product was Thalidomide amide-alkylC8-amine PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license. | |||
T83961 |
Thalidomide 5'-amine-alkylC6-amine
|
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Thalidomide 5'-amine-alkylC6-amine是用于PROTAC研究与开发的功能化cereblon配体;包含一个E3连接酶配体和一个带有末端胺基的alkylC6连接器,用于与目标蛋白配体的结合。这是一系列用于PROTAC研发的功能化工具分子之一。 |