S100A3 Protein, Human, Recombinant (His & MBP) is expressed in E. coli expression system with His and MBP tag. The predicted molecular weight is 55.3 kDa and the accession number is P33764.
生物活性 | Testing in progress |
产品描述 | S100A3 Protein, Human, Recombinant (His & MBP) is expressed in E. coli expression system with His and MBP tag. The predicted molecular weight is 55.3 kDa and the accession number is P33764. |
种属 | Human |
表达系统 | E. coli |
标签 | His, MBP |
蛋白编号 | P33764 |
别名 | S100 calcium binding protein A3, S100E |
蛋白构建 | The Human S100A3 (P33764) (Met 1-Gln 101) was fused with an N-terminal polyhistidine-tagged MBP tag at the N-terminus. |
蛋白纯度 | > 95 % as determined by SDS-PAGE |
分子量 | 55.3 kDa (predicted) |
内毒素 | Please contact us for more information. |
缓冲液 | Supplied as sterile PBS, 20% glycerol, pH 7.4. |
复溶方法 | A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information. |
存储 |
It is recommended to store the product under sterile conditions at -20℃ to -80℃. Samples are stable for up to 12 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
运输方式 |
In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice. |
研究背景 | Protein S100-A3, also known as Protein S-100E, S100 calcium-binding protein A3, S100A3 and S100E, is a member of the S-100 family. S100A3 / S100E contains 2 EF-hand domains. S100A3 / S100E is highly expressed in the differentiating cuticular cells within the hair follicle and organized into mature hair cuticles. High concentrations of S100A3 homotetramer might provide the millimolar level of Ca2+required for hair cuticular barrier formation. S100A3 / S100E is a unique member of the Ca2+-binding S100 protein family with the highest cysteine content and affinity for Zn2+. S100A3 / S100E binds both calcium and zinc. S100A3 / S100E probably binds 2 zinc ions per molecule. It may be involved in calcium-dependent cuticle cell differentiation and hair shaft formation. S100A3 plays an important role in calcium-dependent processes leading to hair shaft formation. S100A3 / S100E is a unique protein among all members of the calcium-binding S100 family, is specifically expressed at the inner endocuticle of human hair fibers. Upon hair damage, S100A3 / S100E is released from hair fibers and possibly destabilizes the hair tissue architecture. |
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S100A3 Protein, Human, Recombinant (His & MBP) S100 calcium binding protein A3 S100E recombinant recombinant-proteins proteins protein