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DR4/TRAIL R1 Protein, Human, Recombinant (His)

DR4/TRAIL R1 Protein, Human, Recombinant (His)

产品编号 TMPY-01720
别名: APO2, tumor necrosis factor receptor superfamily member 10a, TRAILR-1, CD261, DR4, TRAILR1, MGC9365, TNFRSF10A

DR4/TRAIL R1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15.7 kDa and the accession number is O00220.

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DR4/TRAIL R1 Protein, Human, Recombinant (His)
规格 价格/CNY 货期 数量
100 μg ¥ 2,530 5日内发货
1 mg ¥ 20,800 5日内发货
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产品目录号及名称: DR4/TRAIL R1 Protein, Human, Recombinant (His) (TMPY-01720)
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生物活性 Testing in progress
产品描述 DR4/TRAIL R1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15.7 kDa and the accession number is O00220.
种属 Human
表达系统 HEK293 Cells
标签 C-His
蛋白编号 O00220
别名 APO2, tumor necrosis factor receptor superfamily member 10a, TRAILR-1, CD261, DR4, TRAILR1, MGC9365, TNFRSF10A
蛋白构建 The Human TNFRSF10A (NP_003835.2) extracellular domain (Met 1-Asn 239) was expressed, fused with a polyhistidine tag at the C-terminus.
蛋白纯度 > 92 % as determined by SDS-PAGE
分子量 15.7 kDa (predicted)
内毒素 < 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液 Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法 A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储

It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted protein solutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

运输方式

In general, Lyophilized powders are shipping with blue ice.

研究背景 Tumor necrosis factor receptor superfamily, member 10a (TRAIL R1), also known as TRAIL receptor 1 (TRAIL R1) or CD261 antigen, is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. TRAIL R1/CD261/TNFRSF10A serves as a receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. TRAIL R1 can promote the activation of NF-kappa-B. TRAIL R1/CD261/TNFRSF10A induces apoptosis of many transformed cell lines but not of normal tissues, even though its death domain-containing receptor, DR4, is expressed on both cell types.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy

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Keywords

DR4/TRAIL R1 Protein, Human, Recombinant (His) APO2 tumor necrosis factor receptor superfamily member 10a DR-4 TRAILR-1 CD261 APO-2 DR 4 TRAILR 1 DR4 APO 2 CD-261 MGC-9365 TRAILR1 CD 261 MGC9365 MGC 9365 TNFRSF10A recombinant recombinant-proteins proteins protein

 

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