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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T22750	DR4485 hydrochloride DR 4485 hydrochloride	Others	Others
	5-HT7 antagonist
T26709	Azadirone
	Azadirone is a limonoid tetranortriterpene. Azadirone can sensitize cancer cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) through ROS-ERK-CHOP-mediated up-regulation of DR4 and DR5 signaling, down-regulation of cell survival prot
T35558	KAAD-Cyclopamine
	Cyclopamine-KAAD is a potent inhibitor of hedgehog signaling with an IC50 value of 20 nM in a Shh-LIGHT2 assay. It blocks binding of BODIPY-cyclopamine to cells expressing Smoothened (Smo) in a dose-dependent manner. Cyclopamine-KAAD is cell-permeable and binds to SmoA1 to promote its exit from the endoplasmic reticulum. It inhibits the invasion and migration (45.9 and 43.3% inhibition, respectively) of Bel-7402 hepatocarcinoma cells and decreases the expression of nuclear glioma-associated onco...
T71230	VMY-1-103
	VMY-1-103 is a potent CDK inhibitor, is also a novel dansylated analog of purvalanol B, was shown to inhibit cell cycle progression and proliferation in prostate and breast cancer cells more effectively than purvalanol B. VMY-1-103 , but not purvalanol B, significantly decreased the proportion of cells in S phase and increased the proportion of cells in G(2)/M. VMY-1-103 increased the sub G(1) fraction of apoptotic cells, induced PARP and caspase-3 cleavage and increased the levels of the Death ...

化合物

DR4485 hydrochloride

Cat.No: T22750

Synonym: DR 4485 hydrochloride

Cat. No.	Product Name	Target	Signaling Pathways
T1678	Nystatin Stamycin,Fungicidin,制霉菌素,Nystavescent	Apoptosis; Antibiotic; Antifungal	Apoptosis; Microbiology/Virology
	Nystatin (Fungicidin) 是一种口服对酵母和支原体有效的多烯类抗真菌抗生素。它能增加质膜对包括氯离子等小单价离子的通透性。它可部分阻止 Oxaliplatin 诱导的脂筏聚集、DR4 和 DR5 聚集的胆固醇隔离试剂，减少细胞凋亡。

天然产物

Nystatin

Cat.No: T1678

Synonym: Stamycin,Fungicidin,制霉菌素,Nystavescent

Target: Apoptosis, Antibiotic, Antifungal

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPK-00708	TRAIL R1/DR4/TNFRSF10A Protein, Human, Recombinant (hFc) TRAIL R1,APO2,DR4,CD261,TRAIL-R,TNFRSF10A,...	Human	HEK293 Cells
	Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) induces apoptosis selectively via its interaction with the death receptors TRAILR1/DR4 and TRAILR2/DR5 in a wide range of cancers, while sparing normal cells. Despite its tremendous potential for cancer therapeutics, the translation of TRAIL into the clinic has been confounded by TRAIL-resistant cancer populations.
TMPK-00707	TRAIL R1/DR4/TNFRSF10A Protein, Human, Recombinant (His & Avi), Biotinylated TNFRSF10A,CD261,DR4,APO2,TRAIL-R,MGC9365,T...	Human	HEK293 Cells
	TRAIL R1/DR4/TNFRSF10A Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 24.7 kDa and the accession number is O00220.
TMPK-00706	TRAIL R1/DR4/TNFRSF10A Protein, Human, Recombinant (His & Avi) DR4,MGC9365,TNFRSF10A,TRAIL-R,TRAIL R1,CD2...	Human	HEK293 Cells
	TRAIL R1/DR4/TNFRSF10A Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 24.7 kDa and the accession number is O00220.
TMPY-01720	DR4/TRAIL R1 Protein, Human, Recombinant (His) APO2,tumor necrosis factor receptor superfamily member 10a,T...	Human	HEK293 Cells
	DR4/TRAIL R1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15.7 kDa and the accession number is O00220.
TMPY-01719	DR4/TRAIL R1 Protein, Human, Recombinant (hFc) TRAILR1,tumor necrosis factor receptor superfamily member 10...	Human	HEK293 Cells
	DR4/TRAIL R1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 41.3 kDa and the accession number is O00220.
TMPJ-00655	TRAIL R1/DR4/TNFRSF10A Protein, Human, Recombinant (His） TRAIL-R1,TNFRSF10A,cytotoxic TRAIL receptor,APO2,CD261 antig...	Human	HEK293 Cells
	Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A) is also known as TNF-related apoptosis-inducing ligand receptor 1 (TRAIL-R1), Death receptor 4 (DR4), CD261 and APO2, which belongs to TNF superfamily. TNFRSF10A / DR4 is widely expressed and high levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K-562 erythroleukemia cells, MCF-7 breast carcinoma cells and activated T-cells. APO2 / TNFRSF10A is receptor for the cytotoxic ligand TNFSF...
TMPK-00171	TRAIL Trimer Protein, Human, Recombinant (His & Flag) TRAIL,Apo-2L,APO2L,TL2,Apo-2 ligand,CD253,TNFSF10	Human	HEK293 Cells
	Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the TNF superfamily that can initiate the apoptosis pathway by binding to its associated death receptors DR4 and DR5. The activation of the TRAIL pathway in inducing tumor-selective apoptosis leads to the development of TRAIL-based cancer therapies, which include recombinant forms of TRAIL, TRAIL receptor agonists, and other therapeutic agents.