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CD8 alpha Protein, Human, Recombinant (hFc)

产品编号 TMPY-05364

别名: Leu-2, p32 186910, p32, CD8 α, CD8 alpha, MAL, CD8, CD8a molecule, Leu2

CD8 alpha Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 44.3 kDa and the accession number is P01732-1.

TargetMol的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

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CD8 alpha Protein, Human, Recombinant (hFc)

规格	价格/CNY		货期	数量
100 μg	￥ 4,470		现货
200 μg	￥ 7,900		5日内发货
500 μg	￥ 16,710		5日内发货

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生物活性	Testing in progress
产品描述	CD8 alpha Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 44.3 kDa and the accession number is P01732-1.

种属	Human
表达系统	HEK293 Cells
标签	C-hFc
蛋白编号	P01732-1
别名	Leu-2, p32 186910, p32, CD8 α, CD8 alpha, MAL, CD8, CD8a molecule, Leu2
蛋白构建	The Human CD8A (NP_001759.3) (Met1-Asp182) was expressed with the Fc region of Human IgG1 at the C-terminus.
蛋白纯度	> 95 % as determined by SDS-PAGE.
分子量	44.3 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted protein solutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	T-cell surface glycoprotein CD8 alpha chain, also known as CD8a, is a single-pass type I membrane protein. The CD8 glycoprotein is expressed by thymocytes, mature T cells and natural killer (NK) cells and has been implicated in the recognition of monomorphic determinants on major histocompatibility complex (MHC) Class I antigens, and in signal transduction during the course of T-cell activation. Both human and rodent CD8 antigens are comprised of two distinct polypeptide chains, alpha and beta. The Ig domains of CD8 alpha are involved in controlling the ability of CD8 to be expressed. Mutation of B- and F-strand cysteine residues in CD8 alpha reduced the ability of the protein to fold properly and, therefore, to be expressed. Defects in CD8A are a cause of familial CD8 deficiency. Familial CD8 deficiency is a novel autosomal recessive immunologic defect characterized by absence of CD8+ cells, leading to recurrent bacterial infections.

参考文献

1. Devine, L. et al., 2000, J Immunol. 164 (2): 833-8. 2. Arcaro, A. et al., 2000, J Immunol. 165 (4): 2068-76. 3. Saha, K. et al., 2001, Nat Med. 7 (1): 65-72. 4. Romero, P. et al., 2005, Eur J Immunol. 35 (11): 3092-4.

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Keywords

CD8 alpha Protein, Human, Recombinant (hFc) Leu-2 p32 186910 p32 CD8 α CD 8 CD8 alpha MAL CD-8 CD8 CD8a molecule Leu2 recombinant recombinant-proteins proteins protein

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