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ANGPT2/Angiopoietin-2 Protein, Human, Recombinant (His), Biotinylated

产品编号 TMPY-05259

别名: angiopoietin 2, Angiopoietin-2, AGPT2, ANG2

ANGPT2/Angiopoietin-2 Protein, Human, Recombinant (His), Biotinylated is expressed in CHO mammalian cells with His tag. The predicted molecular weight is 56.4 kDa and the accession number is O15123-1.

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ANGPT2/Angiopoietin-2 Protein, Human, Recombinant (His), Biotinylated

规格	价格/CNY		货期	数量
20 μg	￥ 1,950		5日内发货
100 μg	￥ 4,620		5日内发货

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生物活性	Testing in progress
产品描述	ANGPT2/Angiopoietin-2 Protein, Human, Recombinant (His), Biotinylated is expressed in CHO mammalian cells with His tag. The predicted molecular weight is 56.4 kDa and the accession number is O15123-1.

种属	Human
表达系统	CHO Cells
标签	C-His
蛋白编号	O15123-1
别名	angiopoietin 2, Angiopoietin-2, AGPT2, ANG2
蛋白构建	The Human ANGPT2 (NP_001138.1) (Met1-Phe496) was expressed with a polyhistidine tag at the C-terminus. The purified protein was biotinylated in vitro.
蛋白纯度	> 95 % as determined by SDS-PAGE.
分子量	56.4 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted protein solutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	Angiopoietin-2 (ANG 2, or ANGPT2), is a member of the ANG family, which plays an important role in angiogenesis during the development and growth of human cancers. Both ANGPT-1 and ANGPT-2 appear to bind to the tyrosine kinase receptor, Tie-2, found primarily on the luminal surface of endothelial cells. ANG-2's role in angiogenesis generally is considered as an antagonist for ANG1, inhibiting ANG1-promoted Tie2 signaling, which is critical for blood vessel maturation and stabilization. ANG-2 modulates angiogenesis in a cooperative manner with another important angiogenic factor, vascular endothelial growth factor A. Genetic studies have revealed that ANG-2 also is critical in lymphangiogenesis during development. ANG-2 has multiple physiologic effects that regulate vascular tone, hormone secretion, tissue growth and neural activity. Several reports indicate that ANG-2 can induce neovascularization in experimental systems due to the expression of different growth factors such as angiopoietin 2, vascular endothelial factor, and its receptor, fibroblast growth factor, platelet derived growth factor, transforming growth factor beta and epidermal growth factor. In addition, ANG-2 is strongly expressed in the vasculature of many tumors and it has been suggested that ANG-2 may act synergistically with other cytokines such as vascular endothelial growth factor to promote tumor-associated Angiogenesis and tumor progression.

参考文献

1. Thomas M,et al.(2009) The role of the Angiopoietins in vascular morphogenesis. Angiogenesis. 12(2): 125-37. 2. Hu B,et al.(2009) Angiopoietin-2: development of inhibitors for cancer therapy. Curr Oncol Rep. 11(2): 111-6. 3. Fiedler U,et al.(2006) Angiopoietins: a link between angiogenesis and inflammation. Trends Immunol. 27: 552-8. 4. Escobar E,et al.(2004) Angiotensin II, cell proliferation and angiogenesis regulator: biologic and therapeutic implications in cancer. Curr Vasc Pharmacol. 2(4): 385-99.

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Keywords

ANGPT2/Angiopoietin-2 Protein, Human, Recombinant (His), Biotinylated AGPT-2 angiopoietin 2 ANG-2 Angiopoietin-2 ANG 2 AGPT 2 AGPT2 ANG2 recombinant recombinant-proteins proteins protein

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