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ALK-4/ACVR1B Protein, Human, Recombinant (hFc)

产品编号 TMPY-05483

别名: ACVRLK4, ACTRIB, ALK4, activin A receptor, type IB, SKR2

ALK-4/ACVR1B Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 38.1 kDa and the accession number is P36896-1.

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ALK-4/ACVR1B Protein, Human, Recombinant (hFc)

规格	价格/CNY		货期	数量
200 μg	￥ 5,750		5日内发货

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参考文献

生物活性	Measured by its binding ability in a functional ELISA. Immobilized human TDGF1-His at 10 μg/mL (100 μL/well) can bind ACVR1B-Fc , the EC50 of human ACVR1B-Fc is 3-20 ng/mL.
产品描述	ALK-4/ACVR1B Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 38.1 kDa and the accession number is P36896-1.

种属	Human
表达系统	HEK293 Cells
标签	C-hFc
蛋白编号	P36896-1
别名	ACVRLK4, ACTRIB, ALK4, activin A receptor, type IB, SKR2
蛋白构建	The Human ACVR1B (NP_004293.1) (Met1-Glu126) was expressed with the Fc region of Human IgG1 at the C-terminus.
蛋白纯度	> 90 % as determined by SDS-PAGE.
分子量	38.1 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	ALK-4 (Activin Receptor-Like Kinase 4) or ACVR1B (Activin A Receptor, type 1B), belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family, and TGFB receptor subfamily. ALK-4/ACVR1B acts as a transducer of activin or activin like ligands signals. Activin binds to either ACVR2A or ACVR2B and then forms a complex with ACVR1B. The known type II activin receptors include ActRII and ActRIIB, while the main type I activin receptor in mammalian cells is ALK-4 (ActRIB). In the presence of activin, type II and type I receptors form complexes whereby the type II receptors activate ALK-4 through phosphorylation. The activated ALK-4, in turn, transduces signals downstream by phosphorylation of its effectors, such as Smads, to regulate gene expression and affect cellular phenotype. ALK-4/ACVR1B is an important regulator of vertebrate development, with roles in mesoderm induction, primitive streak formation, gastrulation, dorsoanterior patterning, and left-right axis determination.

参考文献

1. Chen Y, et al. (2005) Developmental analysis of activin-like kinase receptor-4 (ALK4) expression in Xenopus laevis. 232(2): 393-8.J. 2. Massagu. (1998) TGF- SIGNAL TRANSDUCTION. Annual Review of Biochemistry. 67: 753-91.

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Keywords

ALK-4/ACVR1B Protein, Human, Recombinant (hFc) ALK-4 ALK 4 ACVRLK4 ACTRIB ALK4 activin A receptor, type IB ACVRLK-4 SKR-2 ACVRLK 4 SKR2 SKR 2 recombinant recombinant-proteins proteins protein

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