抑制性免疫检查点蛋白

抑制性免疫检查点分子在维持免疫稳态中起着至关重要的作用：它们效应 T 细胞上的表达确保了效应 T 细胞反应的适当紧缩；它们在调节性 T (Treg) 细胞上的表达促进了Treg细胞的抑制功能。阻断共抑制分子已被证实可以增强宿主对各种癌症的免疫应答，在癌症治疗中表现出显著的临床效果。

Cat. No.	Product Name / Synonyms	Species	Expression System
TMPY-05345	TIGIT Protein, Cynomolgus, Recombinant (hFc) TIGIT Protein, Cynomolgus, Recombinant (hFc)	Cynomolgus	HEK293
TMPY-05345	TIGIT, also known as V-set and transmembrane domain-containing protein 3 (VSTM3) or V-set and immunoglobulin domain-containing protein 9 (VSIG9) is a new surface...
TMPY-01342	CD73 Protein, Mouse, Recombinant (His) CD73 Protein, Mouse, Recombinant (His)	Mouse	HEK293
TMPY-01342	5'-nucleotidase, also known as NT5E, NTE, and CD73, is a cell membrane protein that belongs to the 5'-nucleotidase family. CD73 is a glycosylphosphatidylinositol...
TMPY-05092	LAG-3 Protein, Cynomolgus, Recombinant (74 Pro, His) LAG-3 Protein, Cynomolgus, Recombinant (74 Pro, His)	Cynomolgus	HEK293
TMPY-05092	LAG3 (Lymphocyte Activating 3) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. LAG3, also known as CD223 and Lymphocyte acti...
TMPY-05079	PD-1 Protein, Human, Recombinant (mFc) PD-1 Protein, Human, Recombinant (mFc)	Human	HEK293
TMPY-05079	Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively reg...
TMPY-04342	PD-1 Protein, Canine, Recombinant (His) PD-1 Protein, Canine, Recombinant (His)	Canine	HEK293
TMPY-04342	Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively reg...
TMPY-03377	CD73 Protein, Cynomolgus, Recombinant (His) CD73 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293
TMPY-03377	5'-nucleotidase, also known as NT5E, NTE, and CD73, is a cell membrane protein that belongs to the 5'-nucleotidase family. CD73 is a glycosylphosphatidylinositol...
TMPJ-00211	CD47 Protein, Human, Recombinant (His) CD47 Protein, Human, Recombinant (His)	Human	Human Cells
TMPJ-00211	CD47(Integrin-Associated Protein,IAP) is a 40 ‑ 60 kDa variably glycosylated atypical member of the immunoglobulin superfamily. The ubiquitously expressed CD47 b...
TMPY-01851	CD73 Protein, Human, Recombinant (His) CD73 Protein, Human, Recombinant (His)	Human	HEK293
TMPY-01851	5'-nucleotidase, also known as NT5E, NTE, and CD73, is a cell membrane protein that belongs to the 5'-nucleotidase family. CD73 is a glycosylphosphatidylinositol...
TMPY-03540	CD73 Protein, Rat, Recombinant (His) CD73 Protein, Rat, Recombinant (His)	Rat	HEK293
TMPY-03540	5'-nucleotidase, also known as NT5E, NTE, and CD73, is a cell membrane protein that belongs to the 5'-nucleotidase family. CD73 is a glycosylphosphatidylinositol...
TMPY-05191	CD47 Protein, Human, Recombinant, Biotinylated CD47 Protein, Human, Recombinant, Biotinylated	Human	HEK293
TMPY-05191	CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain and is a receptor for the C-terminal cell binding domain of thrombospondin. It may play a role in mem...
TMPY-05579	PVRL1/NECTIN1 Protein, Human, Recombinant (hFc), Biotinylated PVRL1/NECTIN1 Protein, Human, Recombinant (hFc), Biotinylated	Human	HEK293
TMPY-05579	Poliovirus receptor-related 1 (herpesvirus entry mediator C; nectin-1; CD111), also known as PVRL1 is a cell adhesion molecule belonging to the immunoglobulin su...
TMPY-05641	B7-H3 Protein, Human, Recombinant (His & Avi), Biotinylated B7-H3 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293
TMPY-05641	B7-H3 is a member of the B7 family of immune regulatory ligands that is thought to attenuate peripheral immune responses through co-inhibition. It plays an impor...