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TNFR2/CD120b/TNFR1B Protein, Cynomolgus, Recombinant (His)

TNFR2/CD120b/TNFR1B Protein, Cynomolgus, Recombinant (His)

产品编号 TMPK-01382   CAS TMPK-01382
别名: p75TNFR, p75TBPII, CD120b, TNF-R75, TNFR1B, TNFR2, TNF-R2, Etanercept, TBPII, TNFRSF1B, TNFBR, TNF RII, TNFR80

Tumor Necrosis Factor Receptor II (TNF RII), also known as TNFRSF1B, p75/p80, and CD120b, is a type I transmembrane protein that belongs to the TNF receptor superfamily. It has a molecular weight of approximately 75 kDa.Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.

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TNFR2/CD120b/TNFR1B Protein, Cynomolgus, Recombinant (His) Chemical Structure
TNFR2/CD120b/TNFR1B Protein, Cynomolgus, Recombinant (His), CAS TMPK-01382
规格 价格/CNY 货期 数量
100 μg ¥ 2,360 5日内发货
500 μg ¥ 9,490 5日内发货
1 mg ¥ 15,800 5日内发货
产品目录号及名称: TNFR2/CD120b/TNFR1B Protein, Cynomolgus, Recombinant (His) (TMPK-01382)
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参考文献
产品描述 Tumor Necrosis Factor Receptor II (TNF RII), also known as TNFRSF1B, p75/p80, and CD120b, is a type I transmembrane protein that belongs to the TNF receptor superfamily. It has a molecular weight of approximately 75 kDa.Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.
别名 p75TNFR, p75TBPII, CD120b, TNF-R75, TNFR1B, TNFR2, TNF-R2, Etanercept, TBPII, TNFRSF1B, TNFBR, TNF RII, TNFR80
分子量 26.1 kDa (predicted). Due to glycosylation, the protein migrates to 49-60 kDa based on Tris-Bis PAGE result.
CAS No. TMPK-01382

存储

Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6~12 month

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TargetMol Library Books参考文献

1. Vanamee, et al. TNFR2: A Novel Target for Cancer Immunotherapy[J]. Trends in Molecular Medicine, 2017:S1471491417301697.

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Keywords

TNFR2/CD120b/TNFR1B Protein, Cynomolgus, Recombinant (His) TMPK-01382 p75TNFR p75TBPII CD120b TNF-R75 TNFR1B TNFR2 TNFR 80 TNFR-2 TNFR 2 TNF-R2 Etanercept TBPII TNFRSF1B TNFBR TNFR-80 TNF RII TNFR80 Inhibitor inhibitor inhibit

 

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