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LIGHT/TNFSF14 Protein, Human, Recombinant (Avi & Fc), Biotinylated

LIGHT/TNFSF14 Protein, Human, Recombinant (Avi & Fc), Biotinylated

产品编号 TMPY-05643
别名: CD258, LTg, tumor necrosis factor (ligand) superfamily, member 14, HVEML, TR2, LIGHT

LIGHT, also known as TNFSF14 or CD258, is a newly identified member of the TNF superfamily (TNFSF14) that is expressed by activated T lymphocytes, monocytes, granulocytes, spleen cells, and immature dendritic cells. TNFSF14 / LIGHT / CD258 is a type II transmembrane protein that is known to bind 2 membrane-bound TNFSF signaling receptors: HVEM, which is predominantly expressed by T cells, and lymphotoxin β receptor (LTβR), which is expressed by stromal cells and nonlymphoid hematopoietic cells. TNFSF14 / LIGHT / CD258 also binds to a soluble non-signaling receptor, decoy receptor 3 (DcR3), which can modulate the function of LIGHT in vivo. TNFSF14 / LIGHT / CD258 can also costimulate T cell responses via HVEM, which is constitutively expressed in most lymphocyte subpopulations, including CD4+and CD8+T cells. In addition, TNFSF14 / LIGHT / CD258 has been shown to suppress tumor formation in vivo and to induce tumor cell apoptosis via the up-regulation of intercellular adhesion molecule 1 and an increased lymphocyte adhesion to cancer cells. Thus, TNFSF14 / LIGHT / CD258 is being actively investigated as a possible basis for cancer treatment.Cancer ImmunotherapyCo-stimulatory Immune Checkpoint TargetsImmune CheckpointImmune Checkpoint ProteinsImmune Checkpoint TargetsImmunotherapyTargeted Therapy

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LIGHT/TNFSF14 Protein, Human, Recombinant (Avi & Fc), Biotinylated Chemical Structure
LIGHT/TNFSF14 Protein, Human, Recombinant (Avi & Fc), Biotinylated, CAS N/A
规格 价格/CNY 货期 数量
20 μg ¥ 2,940 5日内发货
100 μg ¥ 6,800 5日内发货

LIGHT/TNFSF14 Protein, Human, Recombinant (Avi & Fc), Biotinylated 的其他形式现货产品:

HVEM Protein, Human, Recombinant (His) Lamotrigine
产品目录号及名称: LIGHT/TNFSF14 Protein, Human, Recombinant (Avi & Fc), Biotinylated (TMPY-05643)
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参考文献
产品描述 LIGHT, also known as TNFSF14 or CD258, is a newly identified member of the TNF superfamily (TNFSF14) that is expressed by activated T lymphocytes, monocytes, granulocytes, spleen cells, and immature dendritic cells. TNFSF14 / LIGHT / CD258 is a type II transmembrane protein that is known to bind 2 membrane-bound TNFSF signaling receptors: HVEM, which is predominantly expressed by T cells, and lymphotoxin β receptor (LTβR), which is expressed by stromal cells and nonlymphoid hematopoietic cells. TNFSF14 / LIGHT / CD258 also binds to a soluble non-signaling receptor, decoy receptor 3 (DcR3), which can modulate the function of LIGHT in vivo. TNFSF14 / LIGHT / CD258 can also costimulate T cell responses via HVEM, which is constitutively expressed in most lymphocyte subpopulations, including CD4+and CD8+T cells. In addition, TNFSF14 / LIGHT / CD258 has been shown to suppress tumor formation in vivo and to induce tumor cell apoptosis via the up-regulation of intercellular adhesion molecule 1 and an increased lymphocyte adhesion to cancer cells. Thus, TNFSF14 / LIGHT / CD258 is being actively investigated as a possible basis for cancer treatment.Cancer ImmunotherapyCo-stimulatory Immune Checkpoint TargetsImmune CheckpointImmune Checkpoint ProteinsImmune Checkpoint TargetsImmunotherapyTargeted Therapy
别名 CD258, LTg, tumor necrosis factor (ligand) superfamily, member 14, HVEML, TR2, LIGHT
分子量 46.7 kDa (predicted)

存储

Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6~12 month

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TargetMol Library Books参考文献

1. Ogawa T,et al.(2010) CXCR3 binding chemokine and TNFSF14 over expression in bladder urothelium of patients with ulcerative interstitial cystitis. J Urol. 183(3): 1206-12. 2. Kanodia S,et al.(2010) Expression of LIGHT/TNFSF14 combined with vaccination against human papillomavirus Type 16 E7 induces significant tumor regression. Cancer Res. 70(10): 3955-64. 3. Hosokawa Y,et al.(2010) TNFSF14 coordinately enhances CXCL10 and CXCL11 productions from IFN-gamma-stimulated human gingival fibroblasts. Mol Immunol. 47(4): 666-70.

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Keywords

LIGHT/TNFSF14 Protein, Human, Recombinant (Avi & Fc), Biotinylated CD-258 CD258 TR 2 LTg tumor necrosis factor (ligand) superfamily, member 14 TR-2 CD 258 HVEML TR2 LIGHT Inhibitor inhibitor inhibit

 

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