Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MGAT2-IN-1 is an orally active monoacylglycerol acyltransferase (MGAT2)inhibitor (human and mouse MGAT2 with IC50 of 7.8 and 2.4 nM , respectively).
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
2 mg | ¥ 3,190 | 5日内发货 | ||
5 mg | ¥ 3,730 | 5日内发货 | ||
25 mg | ¥ 13,900 | 10-14周 | ||
50 mg | ¥ 18,300 | 10-14周 | ||
100 mg | ¥ 29,200 | 10-14周 | ||
1 mL * 10 mM (in DMSO) | ¥ 5,390 | 5日内发货 |
产品描述 | MGAT2-IN-1 is an orally active monoacylglycerol acyltransferase (MGAT2)inhibitor (human and mouse MGAT2 with IC50 of 7.8 and 2.4 nM , respectively). |
靶点活性 | MGAT2 (mouse):2.4 nM , MGAT2 (human):7.8 nM |
体内活性 | In the lipid utilization analysis, MGAT2-IN-1 significantly increases free fatty acid (FFA) and acylcarnitine levels. MGAT2-IN-1 (30 mg/kg) also significantly reduces food intake dose dependently, suppresses BW gains. MGAT2-IN-1 shows anti-diabetic effects in mice[1]. |
分子量 | 654.01 |
分子式 | C27H21ClF5N7O3S |
CAS No. | 1800025-30-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 125 mg/mL (191.13 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.529 mL | 7.6451 mL | 15.2903 mL | 38.2257 mL |
5 mM | 0.3058 mL | 1.529 mL | 3.0581 mL | 7.6451 mL | |
10 mM | 0.1529 mL | 0.7645 mL | 1.529 mL | 3.8226 mL | |
20 mM | 0.0765 mL | 0.3823 mL | 0.7645 mL | 1.9113 mL | |
50 mM | 0.0306 mL | 0.1529 mL | 0.3058 mL | 0.7645 mL | |
100 mM | 0.0153 mL | 0.0765 mL | 0.1529 mL | 0.3823 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
MGAT2-IN-1 1800025-30-2 Others MGAT2 IN 1 MGAT-2-IN-1 MGAT2IN1 Inhibitor inhibitor inhibit