keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
L-Propargylglycine ((S)-Propargylglycine) 是一种脯氨酸酶抑制剂。
产品描述 | L-Propargylglycine ((S)-Propargylglycine) is an inhibitor of the enzyme. |
体外活性 |
l-propargylglycine (LPG) irreversibly inhibited the enzyme from Crotalus adamanteus and Crotalus atrox in a dose- and time-dependent manner.?Inactivation was irreversible which was significantly protected by the substrate l-phenylalanine.?A Kitz-Wilson replot of the inhibition kinetics suggested formation of reversible enzyme-LPG complex, which occurred prior to modification and inactivation of the enzyme.?UV-visible and fluorescence spectra of the enzyme and the cofactor strongly suggested formation of covalent adduct between LPG and an active site residue of the enzyme.?A molecular modeling study revealed that the FAD-binding, substrate-binding and the helical domains are conserved in SV-LAAOs and both His223 and Arg322 are the important active site residues that are likely to get modified by LPG. |
别名 | (S)-Propargylglycine, (S)-alpha.Propargylglycine, Propargylglycine, L-炔丙基甘氨酸 |
分子量 | 113.11 |
分子式 | C5H7NO2 |
CAS No. | 23235-01-0 |
keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: Slightly soluble
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
L-Propargylglycine 23235-01-0 Others Inhibitor LPropargylglycine alpha.Propargylglycine L Propargylglycine (S)-Propargylglycine (S)-alpha.Propargylglycine Propargylglycine L-炔丙基甘氨酸 inhibit inhibitor