Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GSK9311 inhibits BRPF bromodomain (pIC50: 6.0 and 4.3 for BRPF1 and BRPF2, respectively). GSK9311 is a less active analog of GSK6853. It can be used as a negative control.
产品描述 | GSK9311 inhibits BRPF bromodomain (pIC50: 6.0 and 4.3 for BRPF1 and BRPF2, respectively). GSK9311 is a less active analog of GSK6853. It can be used as a negative control. |
靶点活性 | BRPF2:4.3 (pic50), BRPF1:6.0 (pic50) |
体外活性 | GSK6853 is a less active analogue of GSK6853 in which the 5-amide is alkylated. GSK6853 is a potent (300 pM), soluble, cell active (20 nM), and highly selective inhibitor of the BRPF1 bromodomain. GSK6853 shows properties suitable for cellular and in vivo studies[1]. |
分子量 | 437.53 |
分子式 | C24H31N5O3 |
CAS No. | 1923851-49-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 30 mg/mL (68.57 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.2856 mL | 11.4278 mL | 22.8556 mL | 57.1389 mL |
5 mM | 0.4571 mL | 2.2856 mL | 4.5711 mL | 11.4278 mL | |
10 mM | 0.2286 mL | 1.1428 mL | 2.2856 mL | 5.7139 mL | |
20 mM | 0.1143 mL | 0.5714 mL | 1.1428 mL | 2.8569 mL | |
50 mM | 0.0457 mL | 0.2286 mL | 0.4571 mL | 1.1428 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
GSK9311 1923851-49-3 Chromatin/Epigenetic Epigenetic Reader Domain GSK-9311 GSK 9311 Inhibitor inhibitor inhibit