Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DL-TBOA inhibited [14C] glutamate uptake in COS-1 cells expressing human EAAT1 and EAAT2, with Ki values of 42 μM and 5.7 μM, respectively. DL-TBOA blocks EAAT4 and EAAT5 in a competitive manner, with Ki values of 4.4 μM and 3.2 μM, respectively. DL-TBOA is an effective non-transportable excitatory amino acid transporter inhibitor with IC50 of 70 μM, 6 μM and 6 μM for excitatory amino acid transporter 1 (EAAT1, EAAT2 and EAAT3), respectively.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
2 mg | ¥ 1,920 | 5日内发货 | ||
25 mg | ¥ 7,690 | 6-8周 | ||
50 mg | ¥ 9,990 | 6-8周 | ||
100 mg | ¥ 15,500 | 6-8周 |
产品描述 | DL-TBOA inhibited [14C] glutamate uptake in COS-1 cells expressing human EAAT1 and EAAT2, with Ki values of 42 μM and 5.7 μM, respectively. DL-TBOA blocks EAAT4 and EAAT5 in a competitive manner, with Ki values of 4.4 μM and 3.2 μM, respectively. DL-TBOA is an effective non-transportable excitatory amino acid transporter inhibitor with IC50 of 70 μM, 6 μM and 6 μM for excitatory amino acid transporter 1 (EAAT1, EAAT2 and EAAT3), respectively. |
靶点活性 | EAAT2 (human):5.7 μM , EAAT1 (human):(ki)42 μM , EAAT4:4.4 μM , EAAT1:70 μM , EAAT5:3.2 μM , EAAT3:6 μM , EAAT2:6 μM |
体外活性 | DL-TBOA reversed the loss of viability caused by oxaliplatin. DL-TBOA (350 μM; 24 hours; HCT116 and LoVo cell lines) treatment can reduce the induction of p53 by SN38 and oxaliplatin. DL-TBOA (70-350 μM; 48 hours; HCT116 and LoVo cell lines) treatment concentration-dependently enhanced SN38-induced loss of vitality. |
分子量 | 239.22 |
分子式 | C11H13NO5 |
CAS No. | 205309-81-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
DL-TBOA 205309-81-5 Metabolism transporter DLTBOA DL TBOA Inhibitor inhibitor inhibit