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Clodronic acid disodium salt

产品编号 T6451 CAS 22560-50-5

别名: Loron, Clodronate Disodium, 氯屈膦酸二钠, Lodronate

Clodronic acid disodium salt (Lodronate) 是一种口服具有活力的破骨细胞骨吸收 (osteoclastic bone resorption) 的抑制剂，是一代双磷酸盐。它可用于高骨转换状态、Paget’s 病和溶骨性骨转移中。

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Clodronic acid disodium salt Chemical Structure

Clodronic acid disodium salt, CAS 22560-50-5

规格	价格/CNY	货期
50 mg	￥ 148	现货
100 mg	￥ 247	现货
200 mg	￥ 397	现货
500 mg	￥ 726	现货

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其他形式的 Clodronic acid disodium salt:

Clodronate disodium tetrahydrate
现货

选择批次

纯度: 100%

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生物活性

化学信息

存储 & 溶解度

参考文献

产品描述

Clodronic acid disodium salt (Lodronate), a bisphosphonate, is a potent antiosteolytic agent which inhibits bone resorption.

体外活性

Clodronate significantly decreases total viability of cultures of J774 cells with EC50 of 300 μM, while liposome-encapsulated Clodronate decreases total viability of cultures of J774 cells with EC50 of 1 μM. Clodronate and liposome-encapsulated Clodronate is metabolized to a nonhydrolyzable adenosine triphosphate (ATP) analog, adenosine 5'-(beta, gamma-dichloromethylene) triphosphate, which can be detected in J774 cell extracts by using fast protein liquid chromatography. [1] Clodronate induces apoptosis in isolated osteoclasts. Clodronate, when administered in liposomes, also induces apoptosis in rat peritoneal macrophages in vitro and in liver macrophages of mice in vivo but not in murine macrophage-like RAW-264 cells. [2] Clodronate delivered into macrophages by liposome will kill these cells as a result of intracellular accumulation and irreversible metabolic damage. [3] Clodronate encapsulated in liposomes (clodrolip) efficiently depletes the phagocytic cells in the murine F9 teratocarcinoma and human A673 rhabdomyosarcoma mouse tumour models resulting in significant inhibition of tumour growth ranging from 75 to >92%, depending on therapy and schedule. [4] Clodronate, a bisphosphonate that lacks a nitrogen, does not inhibit protein isoprenylation but can be metabolized intracellularly to a beta-gamma-methylene (AppCp-type) analog of ATP, which is cytotoxic to macrophages in vitro. Clodronate is metabolited to AppCCl(2)p, and AppCCl(2)p inhibits mitochondrial oxygen consumption by a mechanism that involves competitive inhibition of the ADP/ATP translocase. [5]

别名	Loron, Clodronate Disodium, 氯屈膦酸二钠, Lodronate
分子量	288.86
分子式	CH4Cl2O6P0·2Na
CAS No.	22560-50-5

存储

keep away from direct sunlight　|　Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

H2O: 58.82 mg/mL (203.64 mM), Sonication is recommended.

DMSO: Insoluble

溶液配制表

可选溶剂	浓度体积质量	1 mg	5 mg	10 mg	25 mg
H2O	1 mM	3.4619 mL	17.3094 mL	34.6188 mL	86.5471 mL
	5 mM	0.6924 mL	3.4619 mL	6.9238 mL	17.3094 mL
	10 mM	0.3462 mL	1.7309 mL	3.4619 mL	8.6547 mL
	20 mM	0.1731 mL	0.8655 mL	1.7309 mL	4.3274 mL
	50 mM	0.0692 mL	0.3462 mL	0.6924 mL	1.7309 mL
	100 mM	0.0346 mL	0.1731 mL	0.3462 mL	0.8655 mL

计算器

摩尔浓度计算器

稀释计算器

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分子量计算器

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参考文献

1. Frith JC, et al. J Bone Miner Res, 1997, 12(9), 1358-1367. 2. Selander KS, et al. Mol Pharmacol, 1996, 50(5), 1127-1138. 3. van Rooijen N, et al. J Immunol Methods, 1996, 193(1), 93-99. 4. Zeisberger SM, et al. Br J Cancer, 2006, 95(3), 272-281. 5. Lehenkari PP, et al. Mol Pharmacol, 2002, 61(5), 1255-1262.

剂量换算

对于不同动物的给药剂量换算，您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10 只，您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL)，如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法：取 50 μL DMSO 主液，加入 300 μL PEG300，混匀澄清，再加 50 μL Tween 80，混匀澄清，再加 600 μL ddH2O, 混匀澄清。

第一步：请输入动物实验的基本信息

剂量

mg/kg

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μL

动物数量

第二步：请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。

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