Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CPS-11 (N-(Hydroxymethyl)thalidomide) 是 Thalidomide 类似物,具有显著的抗肿瘤活性,对 MM (多发性骨髓瘤)细胞系表现出更广泛的活性和高效的作用。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 2,350 | 现货 | ||
5 mg | ¥ 7,000 | 现货 | ||
25 mg | ¥ 10,600 | 现货 | ||
50 mg | ¥ 13,800 | 现货 | ||
100 mg | ¥ 17,500 | 现货 |
产品描述 | CPS-11 (N-(Hydroxymethyl)thalidomide) is a Thalidomide analogue that has significant antitumor activity and exhibits a wider range of activity and highly potent effects on the MM (multiple myeloma) cell line. |
体外活性 |
Confirming its ability to target tumor cells in the bone marrow microenvironment, CPS-11 abrogates the ability of bone marrow stromal cells (BMSCs) to induce proliferation of MM cells[1]. Showing virtually no effect on the activation of p38 and only slight, transient activation of ATF2 and HSP27 (0-200 μM, 0 or 4 h), CPS-11 demonstrates its pharmacological behavior[2]. At doses as high as 100 μM, CPS-11 (0-100 μM, 24 or 48 h) exhibits no toxicity to H157 cells, WT MEFs, or the p38α-/- MEFs[2]. Furthermore, CPS-11 (50 μM, 24 or 48 h) does not induce apoptosis in H157 cells[2]. |
别名 | CPS11, CPS 11, N-(Hydroxymethyl)thalidomide |
分子量 | 288.26 |
分子式 | C14H12N2O5 |
CAS No. | 145945-21-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45 mg/mL (156.11 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.4691 mL | 17.3455 mL | 34.6909 mL | 86.7273 mL |
5 mM | 0.6938 mL | 3.4691 mL | 6.9382 mL | 17.3455 mL | |
10 mM | 0.3469 mL | 1.7345 mL | 3.4691 mL | 8.6727 mL | |
20 mM | 0.1735 mL | 0.8673 mL | 1.7345 mL | 4.3364 mL | |
50 mM | 0.0694 mL | 0.3469 mL | 0.6938 mL | 1.7345 mL | |
100 mM | 0.0347 mL | 0.1735 mL | 0.3469 mL | 0.8673 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
CPS-11 145945-21-7 Immunology/Inflammation Metabolism NF-Κb Dehydrogenase NF-κB Reactive Oxygen Species CPS11 CPS 11 N-(Hydroxymethyl)thalidomide Inhibitor inhibitor inhibit