Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Anthraflavic acid (2,6-Dihydroxyanthraquinone) 是一种特异性细胞色素 P-448抑制剂,细胞色素 P-448 是与许多化学致癌物质的激活密切相关的酶系统。它是一种类黄酮,有效的IQ 诱变性抑制剂,能够抑制微粒体和胞质激活途径。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
100 mg | ¥ 119 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 195 | 现货 |
产品描述 | Anthraflavic acid (2,6-Dihydroxyanthraquinone), a flavonoid, is a potent IQ mutagenicity and cytochrome P-448 inhibitor. |
体外活性 | Anthraflavic acid is a potent inhibitor of IQ mutagenicity by virtue of its ability to inhibit both its microsomal and cytosolic activation pathways. |
激酶实验 | The metabolic activation of IQ to mutagens was determined using the Ames mutagenicity test ?and employing Salmonella lyphimurium strain TA98 ?and 10% hepatic preparations as activation systems.?IQ and anthraflavic acid were dissolved in DMSO so that the solvent levels never exceeded 100 μl?per phile.?In experiments where microsomes onl~ were used as the activation system, $9 mix was supplemented with 1 unit/plate of glucose-6-phosphate dehydrogenase.?Pre-incubation conditions are described in the appropriate legends. |
别名 | 2,6-二羟基蒽醌, 2,6-Dihydroxyanthraquinone |
分子量 | 240.21 |
分子式 | C14H8O4 |
CAS No. | 84-60-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 48 mg/mL (199.82 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 4.163 mL | 20.8151 mL | 41.6302 mL | 104.0756 mL |
5 mM | 0.8326 mL | 4.163 mL | 8.326 mL | 20.8151 mL | |
10 mM | 0.4163 mL | 2.0815 mL | 4.163 mL | 10.4076 mL | |
20 mM | 0.2082 mL | 1.0408 mL | 2.0815 mL | 5.2038 mL | |
50 mM | 0.0833 mL | 0.4163 mL | 0.8326 mL | 2.0815 mL | |
100 mM | 0.0416 mL | 0.2082 mL | 0.4163 mL | 1.0408 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Anthraflavic acid 84-60-6 Others Inhibitor 2,6-二羟基蒽醌 inhibit 2,6-Dihydroxyanthraquinone inhibitor