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Angiotensin II (3-8), human

产品编号 T5824 CAS 12676-15-2

别名: Angiotensin IV

Angiotensin II (3-8), human 是活性稍弱的血管紧张素AT1受体激动剂。

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Angiotensin II (3-8), human Chemical Structure

Angiotensin II (3-8), human, CAS 12676-15-2

规格	价格/CNY		货期	数量
10 mg	￥ 1,568		5日内发货

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Angiotensin II (3-8), human 的其他形式现货产品:

ANGIOTENSIN IV TFA(12676-15-2(free base))

其他形式的 Angiotensin II (3-8), human:

ANGIOTENSIN IV TFA(12676-15-2(free base))
现货
Angiotensin II (1-4), human
询价
Angiotensin II (5-8), human
询价

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生物活性

化学信息

存储 & 溶解度

参考文献

相关产品

产品描述	Angiotensin II (3-8), human is a less effective agonist at the angiotensin AT1 receptor.
体内活性	Rats with CCH exhibited higher levels of Aβ42, p-tau and pro-inflammatory cytokines in the brain when compared with controls. Infusion of Ang IV significantly reduced the expression of pro-inflammatory cytokines in the brains of rats with CCH. Meanwhile, the reduction of pro-inflammatory cytokines levels caused by Ang IV was reversed by divalinal-Ang IV. During the treatment, the SBP in rats was not significantly altered[1]
动物实验	Eight weeks after bilateral CCA ligation surgery, rats were anaesthetized with 10% chloral hydrate and placed in a stereotactic frame. The scalp was reflected under sterile surgical conditions. A brain-infusion cannula coupled via vinyl tubing to an osmotic pump was implanted into the third cerebral ventricle by surgeons who were blinded to the experimental groups. Osmotic pumps were placed subcutaneously between the scapulae and used to infuse two doses of Ang IV (20 nM, 0.15 μl/h and 100 nM, 0.15 μl/h), divalinal-Ang IV (500 nM, 0.15 μl/h) or aCSF (0.15 μl/h) into the third cerebral ventricle, lasting for six weeks. Following this surgery, the wounds were carefully closed with sutures[1]

别名	Angiotensin IV
分子量	N/A
CAS No.	12676-15-2

存储

keep away from moisture　|　Powder: -20°C for 3 years | In solvent: -80°C for 1 year

计算器

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稀释计算器

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参考文献

1. Wang QG, Xue X, Yang Y,et al.Angiotensin IV suppresses inflammation in the brains of rats with chronic cerebral hypoperfusion[J].J Renin Angiotensin Aldosterone Syst. 2018 Jul-Sep;19(3):1470320318799587. 2. Park B M , Cha S A , Lee S H , et al. Angiotensin IV protects cardiac reperfusion injury by inhibiting apoptosis and inflammation via AT4R in rats[J]. Peptides, 2016, 79:66-74.

剂量换算

对于不同动物的给药剂量换算，您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10 只，您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL)，如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法：取 50 μL DMSO 主液，加入 300 μL PEG300，混匀澄清，再加 50 μL Tween 80，混匀澄清，再加 600 μL ddH2O, 混匀澄清。

第一步：请输入动物实验的基本信息

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第二步：请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。

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