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Methyl alpha-eleostearate

Methyl alpha-eleostearate

产品编号 T36889   CAS 4175-47-7

Methyl alpha-eleostearate (α-ESA) is a conjugated polyunsaturated fatty acid commonly found in plant seed oil. This fatty acid accounts for about 60% of the total fatty acid composition of bitter gourd seed oil and about 70% in tung oil. α-ESA is metabolized and converted to conjugated linoleic acid (9Z,11E-CLA) in rats. It has shown potential as a tumor growth suppressor. In colon cancer Caco-2 cells, α-ESA induced apoptosis through up-regulation of GADD45, p53, and PPARγ. In DLD-1 cells supplemented with α-ESA, apoptosis was induced via lipid peroxidation with an EC50 of 20 μM. It also inhibits DNA polymerases and topoisomerases with IC50s ranging from ~5-20 μM for different isoforms of the enzymes. α-ESA methyl ester is a neutral, more lipid soluble form of the free acid.

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Methyl alpha-eleostearate Chemical Structure
Methyl alpha-eleostearate, CAS 4175-47-7
规格 价格/CNY 货期 数量
1 mg ¥ 822 35日内发货
5 mg ¥ 3,180 35日内发货
10 mg ¥ 4,760 35日内发货
25 mg ¥ 6,930 35日内发货
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产品目录号及名称: Methyl alpha-eleostearate (T36889)
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产品描述 Methyl alpha-eleostearate (α-ESA) is a conjugated polyunsaturated fatty acid commonly found in plant seed oil. This fatty acid accounts for about 60% of the total fatty acid composition of bitter gourd seed oil and about 70% in tung oil. α-ESA is metabolized and converted to conjugated linoleic acid (9Z,11E-CLA) in rats. It has shown potential as a tumor growth suppressor. In colon cancer Caco-2 cells, α-ESA induced apoptosis through up-regulation of GADD45, p53, and PPARγ. In DLD-1 cells supplemented with α-ESA, apoptosis was induced via lipid peroxidation with an EC50 of 20 μM. It also inhibits DNA polymerases and topoisomerases with IC50s ranging from ~5-20 μM for different isoforms of the enzymes. α-ESA methyl ester is a neutral, more lipid soluble form of the free acid.
分子量 292.463
分子式 C19H32O2
CAS No. 4175-47-7

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

DMSO: 30 mg/mL

Ethanol: 100 mg/mL

DMF: 30 mg/mL

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Keywords

Methyl alpha-eleostearate 4175-47-7 9(Z),11(E),13(E) Octadecatrienoic Acid methyl ester Methyl a-eleostearate Methyl α-eleostearate 9(Z),11(E),13(E)Octadecatrienoic Acid methyl ester Inhibitor inhibitor inhibit

 

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