Powder: -20°C for 3 years | In solvent: -80°C for 1 year
β-Aminoarteether (SM934 free base) 是一种具有口服活性的青蒿素衍生物。β-Aminoarteether 可用于炎症和自身免疫疾病研究,如狼疮疾病。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 1,290 | 现货 | ||
5 mg | ¥ 2,990 | 现货 | ||
10 mg | ¥ 4,390 | 现货 | ||
25 mg | ¥ 6,910 | 现货 | ||
50 mg | ¥ 9,480 | 现货 | ||
100 mg | ¥ 12,800 | 现货 | ||
500 mg | ¥ 25,600 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 2,820 | 现货 |
产品描述 | β-Aminoarteether (SM934 free base), an orally active derivative of Artemisinin, serves a pivotal role in the research of inflammation and autoimmune disorders, including those related to lupus diseases. |
体外活性 | β-Aminoarteether (SM934;10 μM; 24 hours) treatment directly enhances IL-10 production and suppresses IL-12/23p40 production in primary peritoneal macrophages with IFN-γ stimulation [1] . In vitro, β-Aminoarteether (SM934) could suppress the Th1 and Th17 polarization, but exerted no influence on Treg differentiation [1] . |
体内活性 | β-Aminoarteether (SM934; 1-10 mg/kg; oral administration; daliy; for 3 months) treatment significantly delays the progression of glomerulonephritis and increases the survival rate of NZB/W F1 mice. β-Aminoarteether treatment promots the IL-10 production of macrophages from NZB/W F1 mice [1] . Animal Model: Female NZB/W F1 mice (Six and half months old) [1] Dosage: 1 mg/kg, 3 mg/kg, and 10 mg/kg Administration: Oral administration; daliy; for 3 months Result: Significantly delayed the progression of glomerulonephritis and increased the survival rate of NZB/W F1 mice. |
别名 | β-Aminoarteether, SM934 free base |
分子量 | 327.42 |
分子式 | C17H29NO5 |
CAS No. | 133162-24-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 60 mg/mL (183.25 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.0542 mL | 15.2709 mL | 30.5418 mL | 76.3545 mL |
5 mM | 0.6108 mL | 3.0542 mL | 6.1084 mL | 15.2709 mL | |
10 mM | 0.3054 mL | 1.5271 mL | 3.0542 mL | 7.6355 mL | |
20 mM | 0.1527 mL | 0.7635 mL | 1.5271 mL | 3.8177 mL | |
50 mM | 0.0611 mL | 0.3054 mL | 0.6108 mL | 1.5271 mL | |
100 mM | 0.0305 mL | 0.1527 mL | 0.3054 mL | 0.7635 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
β-Aminoarteether 133162-24-0 Others SM934 free base SM-934 beta-Aminoarteether SM934 SM 934 b-Aminoarteether Inhibitor inhibitor inhibit