Guanylate cyclase

Guanylate cyclase (also known as guanyl cyclase, guanylyl cyclase, or GC) is a lyase enzyme that converts guanosine triphosphate (GTP) to cyclic guanosine monophosphate (cGMP) and pyrophosphate. It is often part of the G protein signaling cascade that is activated by low intracellular calcium levels and inhibited by high intracellular calcium levels. In response to calcium levels, guanylate cyclase synthesizes cGMP from GTP. cGMP keeps cGMP-gated channels open, allowing for the entry of calcium into the cell.

Cat. No.	Product Name	CAS No.	Purity	Chemical Structure
T6991	Nitroprusside disodium dihydrate 硝普钠二水合物	13755-38-9
Nitroprusside disodium dihydrate (Sodium Nitroprusside Dihydrate) 是一种血管扩张剂，通过在血液中自发释放 NO 发挥作用。它可在谷胱甘肽耗竭的成骨细胞中诱导自噬，用于急性高血压和心力衰竭的研究。
T16808	Runcaciguat 化合物Runcaciguat	1402936-61-1	98%
Runcaciguat 是一种可溶性鸟苷酸环化酶刺激剂。 Runcaciguat 与特异性部分腺苷 A1 受体激动剂相结合，可用于心血管和肾脏疾病的研究。
T76769	Indusatumab 英度妥单抗	1497400-26-6	98%	Indusatumab
Indusatumab (5F9 Monoclonal antibody) 是一种 anti-human GUCY2C (Guanylate cyclase 2C) 单克隆抗体，可用于合成抗体-药物偶联物。
T6888	Methylene Blue 亚甲蓝	61-73-4	98%
Methylene Blue (Tetramethylthionine chloride) 是鸟苷酸环化酶，是单胺氧化酶 A 和 NO 合酶抑制剂。它有抗伤害感受、抗疟疾、抗抑郁和抗焦虑作用，可研究高铁血红蛋白血症、神经退行性疾病和异环磷酰胺引起的脑病。它是血管加压剂，用作色素内窥镜检查中的染料。
T6775	BAY 41-2272 化合物BAY 41-2272	256376-24-6	98%
BAY 41-2272 是一种直接且不依赖一氧化氮的可溶性鸟苷酸环化酶刺激剂。

Cat. No.

Product Name

CAS No.

Purity

Chemical Structure

T6991

Nitroprusside disodium dihydrate

硝普钠二水合物

13755-38-9