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Cat. No.	Product Name	Target	Signaling Pathways
TQ0046	Bavisant JNJ-31001074	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Bavisant (JNJ-31001074) 是一种特异性和口服活性的人 H3 受体拮抗剂。 Bavisant 可用于作用机制的研究，包括觉醒和认知以及 ADHD 的治疗。
T8633	9-FLUORENOL	Dopamine Receptor	GPCR/G Protein; Neuroscience
	9-FLUORENOL 是一种多巴胺再摄取抑制剂，IC50 为 9 µM，是一种化合物的主要代谢物，被开发为一种觉醒促进剂。
TP1982	Neuropeptide S(Rat) Neuropeptide S (Rat)
	Potent endogenous neuropeptide S receptor (NSPR) agonist (EC50 = 3.2 nM). Increases locomotor activity and wakefulness in mice. Also reduces anxiety-like behavior in mice.
T29671	Adrafinil, (R)- UNII-Z61JQF40LJ,Adrafinil (R)-,R-(+)-Adrafinil
	Adrafinil, (R)- is the R isomer of Adrafinil -- a eugeroic that was formerly used to promote alertness, attention, wakefulness, mood, and other parameters, particularly in the elderly.
T10462	Bavisant dihydrochloride	Others	Others
	Bavisant (JNJ-310010740) dihydrochloride is a highly selective, orally active antagonist of the human H3 receptor with a novel mechanism of action, involving wakefulness and cognition.
T28680	SB-215505
	SB215505 is a potent 5-HT2B/2C receptor antagonist (pKi values are 8.3, 7.66 and 6.77 for 5-HT2B, 5-HT2C and 5-HT2A respectively). It Increases wakefulness and motor activity in rats.
T75951	Neuropeptide S(Rat) TFA
	Neuropeptide S(Rat) TFA, a robust endogenous agonist for the neuropeptide S receptor (NSPR) with an EC50 of 3.2 nM, enhances locomotor activity and promotes wakefulness while concurrently diminishing anxiety-like behavior in mice.
T75950	Neuropeptide S(Mouse) TFA
	Neuropeptide S(Mouse) TFA, an endogenous agonist for the neuropeptide S receptor (NPSR) with an EC50 value of 3 nM, plays a significant role in physiological processes by inducing the mobilization of intracellular Ca2+. This compound elevates locomotor activity and wakefulness, and simultaneously decreases anxiety-like behavior in mice.
TP1981	Neuropeptide S(Mouse) Neuropeptide S (Mouse)
	Potent endogenous neuropeptide S receptor (NPSR) agonist (EC50 = 3 nM). Induces mobilization of intracellular Ca2+. Increases locomotor activity and wakefulness in mice. Also reduces anxiety-like behavior in mice.
TP1983	Neuropeptide S (human)
	Potent endogenous neuropeptide S receptor agonist (EC50 = 9.4 nM). Increases locomotor activity and wakefulness in mice. Also reduces anxiety-like behavior in mice.
T38172	RO 5263397 hydrochloride
	Potent trace amine 1 (TA1) receptor agonist (EC50 values are 0.12, 35 and 17-85 nM for mouse, rat and human receptors, respectively). Increases wakefulness and reduces REM and NREM sleep duration in wild type mice. Inhibits spontaneous locomotor activity in dopamine transport (DAT) knockout mice. Espinoza et al (2018) Biochemical and functional characterization of the trace amine-associated receptor 1 (TAAR1) agonist RO5263397. Front.Pharmacol. 9 645 PMID:29977204 \|Galley et al (2015) Discovery ...
T78636	Firazorexton hydrate TAK-994
	Firazorexton hydrate (TAK-994)为一种高效的食欲素2型受体(OX2R)激动剂，EC50值为19 nM。在发作性睡病小鼠模型中，该化合物能够有效减少觉醒碎片和猝倒样发作的发生。
T36591	ABD459
	ABD459 is a neutral antagonist of the central cannabinoid 1 (CB1) receptor (Ki = 8.6 nM). It inhibits food consumption in nonfasted mice without affecting motor activity. ABD459 reduces active food seeking for 5-6 hours after treatment, with no rebound after washout. ABD459 also diminishes rapid eye movement (REM) sleep, with no alterations of wakefulness or non-REM sleep.
T71327	Paraxanthine-d6
	Paraxanthine-d6 is intended for use as an internal standard for the quantification of paraxanthine by GC- or LC-MS. Paraxanthine is an active metabolite of caffeine. It is formed via N3-demethylation of caffeine by the cytochrome P450 (CYP) isoform CYP1A2. Paraxanthine is an adenosine A1 and A2 receptor antagonist. In vivo, paraxanthine increases striatal cGMP and extracellular striatal dopamine levels and locomotor activity, as well as inhibits motor depression induced by the adenosine A1 agoni...
T10462L	Bavisant dihydrochloride hydrate JNJ31001074AAC	Others	Others
	Bavisant dihydrochloride hydrate (JNJ31001074AAC) is a highly selective, orally active antagonist of the human H3 receptor with a novel mechanism of action, involving wakefulness and cognition, with potential as a treatment for ADHD. in vivo: Mean change
T61197	Irdabisant hydrochloride
	Irdabisant (CEP-26401) hydrochloride 是一种选择性、口服活性的组胺H3受体拮抗剂/逆激动剂，具备良好的血脑屏障渗透性。该化合物对大鼠和人类的H3受体具有高亲和力，其Ki值分别为7.2 nM和2.0 nM。此外，Irdabisant hydrochloride在抑制hERG电流方面表现出较低的活性，IC50为13.8 μM。在大鼠社会认知模型中，它展现了认知增强和唤醒的效果，可作为精神分裂症或认知障碍研究的潜在工具。

化合物

Cat.No: TQ0046

Synonym: JNJ-31001074

Target: Histamine Receptor

Cat.No: T8633

Target: Dopamine Receptor

Neuropeptide S(Rat)

Cat.No: TP1982

Synonym: Neuropeptide S (Rat)

Adrafinil, (R)-

Cat.No: T29671

Synonym: UNII-Z61JQF40LJ,Adrafinil (R)-,R-(+)-Adrafinil

Bavisant dihydrochloride

Cat.No: T10462

Target: Others

Cat.No: T28680

Neuropeptide S(Rat) TFA

Cat.No: T75951

Neuropeptide S(Mouse) TFA

Cat.No: T75950

Neuropeptide S(Mouse)

Cat.No: TP1981

Synonym: Neuropeptide S (Mouse)

Neuropeptide S (human)

Cat.No: TP1983

RO 5263397 hydrochloride

Cat.No: T38172

Firazorexton hydrate

Cat.No: T78636

Synonym: TAK-994

Cat.No: T36591

Paraxanthine-d6

Cat.No: T71327

Bavisant dihydrochloride hydrate

Cat.No: T10462L

Synonym: JNJ31001074AAC

Target: Others

Irdabisant hydrochloride

Cat.No: T61197

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