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抑制剂 & 化合物

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T0324	Isoxsuprine hydrochloride Duvadilan,Isolait,盐酸异克舒令,盐酸苯氧丙酚胺	Adrenergic Receptor; iGluR	GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience
	Isoxsuprine hydrochloride (Isolait) 是 β 肾上腺素受体激动剂和NMDA 受体拮抗剂，对子宫肌层和胎盘的 β 肾上腺素受体的Ki 值分别为 13.65 和 3.48 μM。
T1433	Ritodrine hydrochloride DU21220,盐酸利托君,Ritodrine HCl,NSC 291565	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Ritodrine hydrochloride (NSC 291565) 是一种 β-2肾上腺素受体激动剂。
T34639	Sigetin
	Sigetin affects the transport of calcium and magnesium in uterine smooth muscle and can be used in fetal development.
T36154	15(S)-15-methyl Prostaglandin E2 15(S)-15-methyl Prostaglandin E2
	15(S)-15-methyl PGE2 is a potent, metabolically stable analog of PGE2. It is a potent gastric antisecretory and antiulcer compound. 15(S)-15-methyl PGE2 binds to human myometrium with twice the affinity of PGE2 and is ten times more potent than PGE1 in contracting uterine smooth muscle.
T69303	Isoxsuprine Free Base
	Isoxsuprine Free Base is a beta-adrenergic agonist that causes direct relaxation of uterine and vascular smooth muscle. Its vasodilating actions are greater on the arteries supplying skeletal muscle than on those supplying skin. It is used in the treatment of peripheral vascular disease and in premature labor.
T36859	C16 Globotriaosylceramide (d18:1/16:0) C16 Globotriaosylceramide (d18:1/16:0)
	C16 globotriaosylceramide is an endogenous sphingolipid found in mammalian cell membranes that is synthesized from C16 lactosylceramide . C16 globotriaosylceramide acts as a receptor for Shiga toxin in B cell-derived Raji cells and THP-1 monocytes. It accumulates in endothelial cells, pericytes, vascular smooth muscle cells, renal epithelial cells, dorsal ganglia neuronal cells, and myocardial cells in patients with Fabry disease. C16 globotriaosylceramide is also upregulated in plasma of patien...
T35669	Neuromedin C (trifluoroacetate salt)
	Neuromedin C is a bombesin-like neuropeptide that stimulates uterine smooth muscle contraction and the release of gastrin , somatostatin, and amylase in rats. Neuromedin C is a truncated form of gastrin-releasing peptide corresponding to the GRP amino acids 18-27. It inhibits GRP and bombesin binding to rat pancreatic membranes (IC50s = 0.4 and 2.2 nM, respectively), which can be reduced by sodium chloride and guanylyl imidodiphosphate . Neuromedin C induces scratching and mast cell degranulatio...
T76565	PDC31
	PDC31 (THG113.31; ILGHXDYK) 是FPProstaglandin Receptor 的变构和非竞争性抑制剂。PDC31是基于D-氨基酸的寡肽，用作平滑肌收缩剂。PDC31 在体内降低子宫收缩的强度和持续时间，可用于早产和原发性痛经 (PD) 的研究。PDC31 还增强人子宫肌层细胞中 Ca2+依赖性大电导 K+通道。

化合物

Isoxsuprine hydrochloride

Cat.No: T0324

Synonym: Duvadilan,Isolait,盐酸异克舒令,盐酸苯氧丙酚胺

Target: Adrenergic Receptor, iGluR

Ritodrine hydrochloride

Cat.No: T1433

Synonym: DU21220,盐酸利托君,Ritodrine HCl,NSC 291565

Target: Adrenergic Receptor

15(S)-15-methyl Prostaglandin E2

Cat.No: T36154

Synonym: 15(S)-15-methyl Prostaglandin E2

Target:

Isoxsuprine Free Base

Cat.No: T69303

Synonym:

Target:

C16 Globotriaosylceramide (d18:1/16:0)

Cat.No: T36859

Synonym: C16 Globotriaosylceramide (d18:1/16:0)

Target:

Neuromedin C (trifluoroacetate salt)

Cat. No.	Product Name	Target	Signaling Pathways
T8288	14-Deoxyandrographolide 去氧穿心莲内酯,14-去氧穿心莲内酯	Apoptosis; Others	Apoptosis; Others
	14-Deoxyandrographolide 是穿心莲中的一种天然产物，是一种钙通道阻断剂，具有保肝功效。它通过诱导 TNFRSF1A 的释放，使肝细胞对 TNF-α 介导的凋亡脱敏。
TN1248	3-Epioleanolic acid	AChR	Neuroscience
	3-Epioleanolic acid 是一种分离自马鞭草的有效成分，具有抗炎作用。
T83454	13-Hydroxylupanine hydrochloride Hydroxylupanine hydrochloride
	13-Hydroxylupanine是甜羽扇豆中一种典型的生物碱。它具有阻断神经节传递、降低心肌收缩力以及收缩子宫平滑肌的作用。