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Cat. No.	Product Name	Target	Signaling Pathways
T13951	UCB-9260	TNF	Apoptosis
	UCB-9260 是口服活性小分子，通过稳定三聚体的不对称形式抑制肿瘤坏死因子信号传导。它对肿瘤坏死因子的选择性高于其他超家族成员，并与肿瘤坏死因子结合，其Kd 值为 13 nM。
T30881	Chir 4531 Chir4531,Chir-4531
	Chir 4531 is a N-(substituted)glycine peptoid trimer.
T36097	TNF-α-IN-2
	TNF-α-IN-2 is a highly potent and orally bioavailable inhibitor of tumor necrosis factor alpha (TNFα), exhibiting an IC50 of 25 nM in the HTRF assay. It exerts its inhibitory effects by inducing conformational changes in the TNFα trimer upon binding, resulting in disrupted signaling when the trimer interacts with TNFR1. TNF-α-IN-2 holds promise as a valuable tool for investigating the pathogenesis of rheumatoid arthritis[1].
T71452	trans-Miyabenol C
	trans-Miyabenol C is a natural resveratrol trimer, acting as a protein kinase C inhibitor.
T30880	Chir 2279 Chir2279
	Chir 2279 is a N-(substituted)glycine peptoid trimer with high-affinity binding for alpha 1-adrenoceptors. CHIR 2279 antagonized the epinephrine-induced increase in intraurethal pressure (pseudo pA2, 6.86) in dogs.
T68954	UCB-6876
	UCB-6876 is a novel inhibitor of TNF signalling by stabilising an asymmetric form of the trimer, displaying a concentration-dependent response curve and selectivity over the TNFR1 extracellular domain and control proteins.
T71807	UCB-6786
	UCB-6786 is a novel inhibitor of TNF signalling by stabilising an asymmetric form of the trimer, displaying a concentration-dependent response curve and selectivity over the TNFR1 extracellular domain and control proteins.
T40259	AB-729
	AB-729, a nucleoside analogue functioning as an RNA interference (RNAi), links to a GalNAc (N-acetylgalactosamine) trimer ligand facilitating hepatocyte uptake through the asialoglycoprotein receptor (ASGR). This compound effectively impedes viral replication and diminishes HBV antigens.
T37355	CAY10703
	Dichloroacetate (DCA) is an inhibitor of all pyruvate dehydrogenase kinase (PDHK) isoforms, which are enzymes that phosphorylate and inhibit PDH in mitochondria. Inhibition of PDHK shifts cell metabolism from glycolysis to mitochondrial glucose oxidation, an effect that has relevance to cancer, type 2 diabetes, and other diseases. CAY10703 is a DCA trimer that is at least 10-fold more cytotoxic against leukemia cell lines than DCA. It is approximately 3-fold less cytotoxic than DCA against perip...

化合物

Synonym: Chir4531,Chir-4531

Synonym: Chir2279

Cat. No.	Product Name	Target	Signaling Pathways
TN5746	Gnetifolin E 买麻藤戊素	Others	Others
	Gnetifolin E 是一种新的白藜芦醇三聚体衍生物，来自 Gnetum brunonianum。
T38108	Fulvic Acid	Antioxidant; PDE	Metabolism; oxidation-reduction
	Fulvic Acid 是一种来自土壤、沉积物或水生环境中微生物产生的腐殖质的天然产物，是一种首次青霉菌中分离出的酚酸和真菌代谢产物。Fulvic Acid 抑制淀粉样蛋白b (17-42) (AB17-42)二聚化，破坏预先形成的AB17-42三聚体，并结合到磷酸二酯酶5A (PDE5A)的催化位点，可以调节机体免疫系统，影响细胞的氧化状态，改善胃肠功能。Fulvic Acid 可作为氧化剂或还原剂，具有研究糖尿病等慢性炎症性疾病的潜力。

天然产物

Target: Antioxidant, PDE

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