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Search Results for " thrombopoietin "

Targets Recommended: Thrombopoietin Receptor Thrombin Thrombopoietin Receptor

14

抑制剂 & 化合物

10

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
TQ0223	Lusutrombopag 芦曲泊帕,鲁索曲波帕,S-888711,Mulpleta	Thrombin; Thrombopoietin Receptor	Immunology/Inflammation; Proteases/Proteasome
	Lusutrombopag (Mulpleta) 是一种口服生物可利用的小分子血小板生成素 (TPO) 受体激动剂，用于选择性侵入性手术前患有血小板减少症的慢性肝病的患者。
T2562	Eltrombopag SB-497115,SB-497115-GR,艾曲波帕	Thrombin	Proteases/Proteasome
	Eltrombopag (SB-497115-GR) 是一种具有巨核细胞生成刺激活性的口服活性血小板生成素受体激动剂，可结合并刺激血小板血小板生成素受体，用于血小板减少的某些病症研究。
T6825	Eltrombopag Olamine Promacta Olamine,Revolade,艾曲泊帕乙醇胺盐,Eltrombopag diethanolamine salt,SB497115,艾曲波帕乙醇胺盐,SB-497115GR	Thrombin	Proteases/Proteasome
	Eltrombopag Olamine (Eltrombopag diethanolamine salt) 是 Eltrombopag 的口服活性乙醇胺盐，是一种血小板生成素(TPO)受体激动剂，用于血小板减少的某些病症研究。
T7417	Avatrombopag YM477,AKR-501,1-[3-氯-5-[[[4-(4-氯-2-噻吩基)-5-(4-环己基-1-哌嗪基)-2-噻唑基]氨基]羰基]-2-吡啶基]-4-哌啶羧酸,E5501	Thrombin; Thrombopoietin Receptor	Immunology/Inflammation; Proteases/Proteasome
	Avatrombopag (YM477) 是一种新型口服血小板生成素 (TPO) 受体激动剂，可激活 TPO 受体并增加巨核细胞增殖/分化和血小板生成。
T67894	Butyzamide	Thrombopoietin Receptor; JAK	Angiogenesis; Chromatin/Epigenetic; Immunology/Inflammation; JAK/STAT signaling; Stem Cells
	Butyzamide 是一种有效的可口服的Mpl 激活剂，是一种对血小板生成素(TPO)受体具有拮抗作用的新型非肽基分子，促进表达人Mpl (hMpl)的和小鼠pro B 细胞株Ba/F3的增殖，诱导JAK2、STAT3、STAT5和MAPK 的磷酸化。Butyzamide 在小鼠异种移植试验中有助于提升血小板水平。
T17146	TPO agonist 1	Others	Others
	TPO agonist 1 is a thrombopoietin agonist. It would be useful as promoters of thrombopoiesis and megakaryocytopoiesis to treat thrombocytopenia.
T62865	Rafutrombopag
	Rafutrombopag 是一种血小板生成素 (TPO) 激动剂。
T38602	(E/Z)-Eltrombopag 13C4 (E/Z)-Eltrombopag 13C4,(E/Z)-SB-497115 13C4
	(E/Z)-Eltrombopag 13C4 ((E/Z)-SB-497115 13C4) is a mixture complex of E-Eltrombopag and Z-Eltrombopag, with 13C labeled. Z-Eltrombopag is a thrombopoietin (TPO) receptor agonist developed for certain conditions that lead to thrombocytopenia.
T27536	Hetrombopag olamine
	Hetrombopag olamine is a non-peptide thrombopoietin (TPO) receptor agonist with oral activity.
T68560	Totrombopag choline
	Totrombopag, also known LGD-4665, GSK2285921 and SB559448, is an oral thromobopoietin receptor agonist, is being developed as a new generation small molecule thrombopoietin (TPO) mimetic. It is a highly selective and potent agonist of the TPO receptor and therefore induces differentiation and proliferation of megakaryocytes. The pharmacologic characteristics indicate potential therapeutic use in thrombocytopenic patients with a variety of clinical etiologies.
T40654	Avatrombopag hydrochloride AKR-501 hydrochloride,YM477hydrochloride,E5501hydrochloride
	Avatrombopag hydrochloride (AKR-501) is an orally active, nonpeptide agonist of the thrombopoietin (TPO) receptor with an EC 50 of 3.3 nM. It effectively mimics the biological activities of TPO, stimulating platelet production by activating the intracellular signaling system and facilitating the generation of platelets and megakaryocytes from hemopoietic precursor cells. Additionally, Avatrombopag hydrochloride serves as a substrate for cytochrome P450 (CYP) 2C9 and CYP3A.
T72265	Eltrombopag methyl ester
	Eltrombopag methyl ester，一种Eltrombopag衍生物，为促血小板生成素(Tpo)受体激动剂，旨在促进血小板生成，用于研究特定类型的血小板减少症。
T62864	Hetrombopag
	Hetrombopag 是一种 thrombopoietin receptor 的有效激动剂。Hetrombopag 具有良好的耐受性且安全性可控。Hetrombopag 具有潜力进行免疫性血小板减少症的研究。
T68888	Avatrombopag maleate
	Avatrombopag, also known as AKR-501, YM477, AS 1670542 or E5501, is a novel orally-active thrombopoietin (TPO) receptor agonist. AKR-501 specifically targeted the TPO receptor and stimulated megakaryocytopoiesis throughout the development and maturation of megakaryocytes just as rhTPO did. AKR-501 may be useful in the treatment of patients with thrombocytopenia. Avatrombopag was first approved in 2018.

化合物

Cat.No: TQ0223

Synonym: 芦曲泊帕,鲁索曲波帕,S-888711,Mulpleta

Target: Thrombin, Thrombopoietin Receptor

Cat.No: T2562

Synonym: SB-497115,SB-497115-GR,艾曲波帕

Target: Thrombin

Eltrombopag Olamine

Cat.No: T6825

Synonym: Promacta Olamine,Revolade,艾曲泊帕乙醇胺盐,Eltrombopag diethanolamine salt,SB497115,艾曲波帕乙醇胺盐,SB-497115GR

Target: Thrombin

Cat.No: T7417

Synonym: YM477,AKR-501,1-[3-氯-5-[[[4-(4-氯-2-噻吩基)-5-(4-环己基-1-哌嗪基)-2-噻唑基]氨基]羰基]-2-吡啶基]-4-哌啶羧酸,E5501

Target: Thrombin, Thrombopoietin Receptor

Cat.No: T67894

Target: Thrombopoietin Receptor, JAK

Cat.No: T17146

Target: Others

Cat.No: T62865

(E/Z)-Eltrombopag 13C4

Cat.No: T38602

Synonym: (E/Z)-Eltrombopag 13C4,(E/Z)-SB-497115 13C4

Hetrombopag olamine

Cat.No: T27536

Totrombopag choline

Cat.No: T68560

Avatrombopag hydrochloride

Cat.No: T40654

Synonym: AKR-501 hydrochloride,YM477hydrochloride,E5501hydrochloride

Eltrombopag methyl ester

Cat.No: T72265

Cat.No: T62864

Avatrombopag maleate

Cat.No: T68888

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-00939	Thrombopoietin Protein, Mouse, Recombinant (His) thrombopoietin,Mpllg,Tpo,Mgdf,Ml	Mouse	HEK293 Cells
	Thrombopoietin Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 37 kDa and the accession number is P40226-1.
TMPY-01609	Thrombopoietin Protein, Cynomolgus, Recombinant (His) thrombopoietin	Cynomolgus	HEK293 Cells
	Thrombopoietin Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 36.8 kDa and the accession number is XP_005546625.1.
TMPY-05423	C-MPL Protein, Rat, Recombinant (hFc) MPL proto-oncogene, thrombopoietin receptor,MPL	Rat	HEK293 Cells
	C-MPL Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 80.7 kDa and the accession number is A0A1W2Q6N1.
TMPY-04201	Thrombopoietin Protein, Human, Recombinant (hFc) MPLLG,MKCSF,THCYT1,thrombopoietin,MGDF,ML,TPO	Human	HEK293 Cells
	Thrombopoietin Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 45 kDa and the accession number is P40225-1.
TMPJ-00235	TPO Protein, Human, Recombinant (His) Megakaryocyte growth and development factor,C-mpl ligand,	Human	HEK293 Cells
	Thrombopoietin (TPO) is a glycoprotein hormone which belongs to the EPO/TPO family. It produced by the liver and kidney which regulates the production of platelets. TPO stimulates the production and differentiation of megakaryocytes, the bone marrow cells that bud off large numbers of platelets. Lineage-specific cytokine affects the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physi...
TMPY-03421	C-MPL Protein, Rat, Recombinant (His) MPL proto-oncogene, thrombopoietin receptor,MPL	Rat	Baculovirus Insect Cells
	C-MPL Protein, Rat, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 55.1 kDa.
TMPY-06863	C-MPL Protein, Mouse, Recombinant (His) c-mpl,MPL proto-oncogene, thrombopoietin receptor,T...	Mouse	HEK293 Cells
	C-MPL Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 52.64 kDa and the accession number is Q08351-1.
TMPY-06797	C-MPL Protein, Human, Recombinant (His) MPL proto-oncogene, thrombopoietin receptor,CD110,T...	Human	HEK293 Cells
	C-MPL Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 54 kDa and the accession number is P40238-1.
TMPK-00874	Thyroid Peroxidase Protein, Mouse, Recombinant (His) MK-CSF,MGDF,ML,MPLLG,THPO,TPOMKCSF,Thrombopoietin,M...	Mouse	HEK293 Cells
	Thyroid peroxidase, also called thyroperoxidase (TPO) or iodide peroxidase that encodes a 933 amino-acid residue (aa) molecule with a single membrane-spanning region. Thyroid peroxidase plays a key role in thyroid hormone synthesis by catalyzing both the iodination of tyrosine residues to form monoiodotyrosine (MIT) and diiodotyrosine (DIT) residues and the coupling of iodotyrosine residues in Tg, resulting in the formation of T3 and T4. It is a frequent epitope of autoantibodies in autoimmune t...
TMPH-02274	JAK2 Protein, Human, Recombinant (His)	Human	E. coli
	Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple int...

重组蛋白

Thrombopoietin Protein, Mouse, Recombinant (His)

Cat.No: TMPY-00939

Species: Mouse

Expression System: HEK293 Cells

Thrombopoietin Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPY-01609

Species: Cynomolgus

Expression System: HEK293 Cells

C-MPL Protein, Rat, Recombinant (hFc)

Cat.No: TMPY-05423

Species: Rat

Expression System: HEK293 Cells

Thrombopoietin Protein, Human, Recombinant (hFc)

Cat.No: TMPY-04201

Species: Human

Expression System: HEK293 Cells

TPO Protein, Human, Recombinant (His)

Cat.No: TMPJ-00235

Species: Human

Expression System: HEK293 Cells

C-MPL Protein, Rat, Recombinant (His)

Cat.No: TMPY-03421

Species: Rat

Expression System: Baculovirus Insect Cells

C-MPL Protein, Mouse, Recombinant (His)

Cat.No: TMPY-06863

Species: Mouse

Expression System: HEK293 Cells

C-MPL Protein, Human, Recombinant (His)

Cat.No: TMPY-06797

Species: Human

Expression System: HEK293 Cells

Thyroid Peroxidase Protein, Mouse, Recombinant (His)

Cat.No: TMPK-00874

Species: Mouse

Expression System: HEK293 Cells

JAK2 Protein, Human, Recombinant (His)

Cat.No: TMPH-02274

Species: Human

Expression System: E. coli

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